Aims. The current study aims to examine the influence of job stress, SOC, and personality traits on depressive state.Methods. A self-reported survey was conducted among 347 female nurses in a general hospital. Job stress was measured using the Japanese version of the Brief-Job Stress Questionnaire scale. Depressive state was assessed by the K6 scale. We used 13-item SOC scale. Personality traits were assessed by the Japanese version of Ten-Item Personality Inventory. Multiple liner regression analyses were conducted to examine predictors that significantly affect depressive state.Results. Job and life satisfaction and SOC negatively related to the depressive state (β=-0.76, P<0.01; β=-0.18, P<0.001, resp.) while neuroticism was positively correlated (β=0.49, P<0.001). Also, intrinsic rewards tended to negatively relate (β=-0.80, P<0.1).Conclusions. From a practical perspective, the possible influence of SOC and neurotic personality on depressive state should be considered for health care professionals.