Our Experience with Inverted Papilloma: about 61 Patients

Introduction: Inverted papilloma (IP) is the most common type of Schneiderian papilloma originating from the mucosal lining of the nose and paranasal cavities. It is a semi benign tumor with a high tendency for recurrences and malignant transformation. Management consists of a complete tumoral resection. Objective: to analyze surgical results considering the techniques (open or endoscopic surgery), the rate and time of recurrence. Method: We present herein a cohort of 61 patients treated in the CHU-UCL Godinne between 1998 and 2019. We analyzed the demographic data, the origin of the tumor, the staging, the surgical approach and the outcomes. The patients were classified into two groups: the first one includes 48 patients operated de novo in CHU-UCL Godinne and the second group 13 patients referred to us for revision surgery. Results: We observed 8 recurrences, all groups confounded. The global success rate was 87%. The number of recurrences in the first group was 6 out of 48 and 2 out of 13 in the second group. Following these results we propose an algorithm of treatment depending on the site of attachment of the IP. Conclusion: We confirmed that more extended surgeries such as Caldwell Luc procedure, medial maxillectomy, Draf IIb/III frontal sinusotomy or type III sphenoidotomy give better outcomes than more “limited” and functional surgeries such as Draf I/IIa frontal sinusotomy or middle antrostomy. The latter should be done only for specific and limited extension of the IP in the maxillary sinus. A subperiosteal dissection is mandatory in all cases. Keywords: inverted papilloma; retrospective study; surgery; recurrence

Closeness-centrality-correlation for detecting interdependency between coupled systems

Generalized synchronization is a common interdependency between coupled systems which exists in many branches of life, social and physical science. In this paper, a novel method, called closeness-centrality-correlation is proposed for the detection of this interdependency. The proposed method is based on a global network measure (i.e., closeness centrality) of recurrence networks resulting from time series. We illustrate the feasibility of the proposed method using a paradigmatic coupled model and compare its performance to other commonly used interdependency methods. The numerical results show that the proposed method is quite satisfactory for detecting interdependency and outperforms the existing joint probability of recurrence method especially for the case that the dynamics of the two coupled subsystems are significantly different. Moreover, through analyzing the time series contaminated by white noise, we demonstrate that our method is robust against white noise. Finally, an application to recorded electroencephalogram data shows that the proposed measure is more reliable to detect the transitions of the interdependencies among the noisy electroencephalogram time series and thus provides longer pre-warning time for the onset of epilepsy.

Easy Computation of the Various Topologies and Modes of Liquid–Liquid Partition Chromatography by the Theory of Random Walks

The article revisits the discrete recurrence method to model the instruments of liquid–liquid partition chromatography as counter-current chromatography (CCC) and centrifugal partition chromatography (CPC). The purpose is to simplify the computation of the concentration profiles without supplementary approximations, rather by going back to the seminal model of binomial random walks, associated with the stochastic master equation that generates simple discrete recurrence relations. It fits the model of the prototype of liquid–liquid chromatography: the Craig’s apparatus. Three emblematic separation technique group cases are computed in batch injection, batch multiple dual mode (MDM), and continuous injection by the “True Moving Bed” (TMB) in CPC.

On the spherical expansion for calculating the sound radiated by a baffled circular piston

An efficient and accurate method for calculating the sound radiated by a baffled circular rigid piston is using spherical harmonics, and the solution is a series containing the integral of spherical Bessel functions. The integral is usually calculated with the generalized hypergeometric functions in existing literatures, which shows poor convergence at middle and high frequencies due to the overflow and the loss of significant figures. A rigorous and closed form solution of the integral is derived in this paper based on the recurrence method, which is accurate in the whole frequency range and thousands of times faster than the existing methods. It is shown that the proposed method can be extended for the calculation of the sound radiated by a baffled piston and an unbaffled resilient disk with axisymmetric velocity and pressure profiles, respectively, and some baffled rotating sources where the velocity profile is asymmetric.

Defibrillation threshold of internal cardioversion prior to ablation predicts atrial fibrillation recurrence

Background: Many studies have reported the predictors of atrial fibrillation (AF) recurrence after persistent AF (peAF) ablation. However, the correlation between the atrial defibrillation threshold (DFT) for internal cardioversion (IC) and AF recurrence rate is little-studied. We investigated the relationship between DFT prior to catheter ablation for peAF and the AF recurrence. Method and Results: From June 2016 to May 2019, we enrolled 82 consecutive patients (mean age 65.0 ± 12.4 years), including 45 patients with peAF and 37 with long-standing peAF, at Hamamatsu medical center. In order to assess the DFT, we performed IC with gradually increasing energy prior to radiofrequency application. Forty-nine and 33 patients showed DFT values less than or equal to 10 J (group A) and greater than 10 J or unsuccessful defibrillation (group B), respectively. During the mean follow-up duration of 20.5 ± 13.1 months, patients in group B showed significantly higher AF recurrence rates than those in group A after the ablation procedure (P = 0.017). Multivariate analysis revealed that the DFT was the only predictive factor for AF recurrence (OR=1.07; 95% CI: 1.00-1.13, P = 0.047). Conclusions: The DFT for IC was one of the strongest prognostic factors in the peAF ablation procedure.

ANALISA KEJADIAN GELOMBANG DENGAN METODE EMPIRIK DAN MODEL MATEMATIK DI KAWASAN PERAIRAN PELABUHAN TANJUNG LAUT

Tanjung Laut is water located in the administrative area of Bontang Regency, East Kalimantan. These waters are widely used for ship traffic to and from the Port. To find out the hydrodynamic conditions, especially waves that occur in the sea and propagate into these waters, it is necessary to analyze wave transformations to describe the conditions and impacts that occur due to wave propagation from the high seas that enter the port waters. The purpose of this study is to look at the shipping security channel. The method used in analyzing wind data from BMKG into wave data and modeling with cgwave mathematical models. Wave analysis is carried out with a cgwave model mathematical to determine the hydrodynamic conditions of the waves and to determine the shipping obstacles and to describe the plan waves that occur as one of the bases in determining the elevation of the pier and port breakwater structures. The results showed the conversion of wind speed and direction to be high, the period and direction of waves in the waters of Tanjung Laut in 2006-2016. The maximum significant wave height in the waters of Tanjung Laut occurred in 2007 was 3.91 meters with a period of 7.89 seconds. The results of statistical analysis using the wave recurrence method show that the wave height can occur or exceed for a 50 year return period is 4.80 meters to 5.54 meters, while the 10 year return period is 3.70 meters to 4.17 meters. The results of the waveform simulation with the cgwave are the wave height in the harbor pool ranging from 0.03 meters to 0.06 meters in the direction of waves from the Northeast, 0.03 meters to 0.07 meters in the direction of waves from the East, and 0.05 meters up to 0.09 meters in the direction of waves from the Southeast. Simulation results show that the conditions in the port pond are quite safe and calm against wave attacksTanjung laut merupakan pelabuhan perairan yang berada di wilayah administrasi Kabupaten Bontang Kalimantan Timur, dimana banyak digunakan untuk lalu lintas kapal yang menuju dan keluar dari Pelabuhan. Untuk mengetahui kondisi hidrodinamika khususnya gelombang yang terjadi di laut dan merambat ke perairan tersebut, perlu adanya analisa transformasi gelombang untuk menggambarkan kondisi dan dampak yang terjadi akibat perambatan gelombang dari laut lepas yang masuk ke kawasan perairan pelabuhan. Tujuan dari penelitian ini adalah untuk melihat keamanan alur pelayaran. Metode yang digunakan yaitu menganalisa data angin dari BMKG menjadi data gelombang dan pemodelan dengan model matematik cgwave. Analisa gelombang dilakukan dengan model matematik model cgwave untuk mengetahui kondisi hidrodinamika gelombang dan untuk mengetahui hambatan pelayaran serta untuk menggambarkan gelombang rencana yang terjadi sebagai salah satu dasar dalam penentuan elevasi dermaga dan bangunan pemecah gelombang pelabuhan. Hasil penelitian menunjukan konversi kecepatan dan arah angin menjadi tinggi, periode dan arah gelombang di perairan Tanjung laut Tahun 2006-2016. Tinggi gelombang signifikan maksimum di perairan Tanjung Laut terjadi pada tahun 2007 adalah 3,91 meter dengan periode 7,89 detik. Hasil analisa statistik menggunakan metode kala ulang kejadian gelombang, menunjukkan tinggi gelombang dapat terjadi atau terlampaui untuk kala ulang 50 tahun adalah 4,80 meter sampai dengan 5,54 meter, sedangkan kala ulang 10 tahun adalah 3,70 meter sampai dengan 4,17 meter. Hasil simulasi trasformasi dgelombang dengan model cgwave adalah tinggi gelombang di kolam pelabuhan berkisar antara 0,03 meter sampai dengan 0,06 meter dengan arah datang gelombang dari Timur Laut, 0,03 meter sampai dengan 0,07 meter dengan arah datang gelombang dari Timur, dan 0,05 meter sampai dengan 0,09 meter dengan arah datang gelombang dari Tenggara. Hasil simulasi menunjukkan kondisi di kolam pelabuhan cukup aman dan tenang terhadap serangan gelombang.

Complete removal of the spinal nerve sheath tumors. Surgical technics and results from a series of 30 patients

Objective: Observe whether a microsurgical gross total removal (GTR) of a spinal nerve sheath tumors (SNSTs) is safe and decreases the tumor recurrence. Method: We identify 30 patients with 44 SNSTs. Results: We operated upon 15 males and 15 females patients; mean age 40 years. GTR was achieved in 29 (96.6%) instances. Surgical mortality was 3.3% and the recurrence rate was 3.3%. The median follow-up time was 6.2 years. Conclusion: The surgical approach used in this group of patients afford that the great majority of tumors could be totally removed with low mortality and low recurrence rates, proving to be safe and effective.