A comparative study of oral Ketoconazole versus Itraconazole in the treatment of Tinea versicolor

Tinea (pityriasis) versicolor is a superficial fungal infection and one of the most commonly found pigmentary disorders of the skin caused by the yeast Malassezia. Multiple topical as well as systemic therapies are available for treatment. Systemic therapies are used for extensive disease, frequent relapse or where topical agents have failed. The aim that translates the rationale of the study was to compare the efficacy, safety, tolerability and cost effectiveness of oral ketoconazole dose 200mg daily for 7 days versus a single dose of 400 mg of itraconazole in the treatment of tinea versicolor. A total of 64 patients (aged 18-50 years) were selected for the study from the period of June 2019 to November 2019 in the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Bangladesh. Cases having extensive involvement were diagnosed clinically and confirmed by wood's lamp and KOH microscopy was taken. Patients were randomly allocated into equal groups. Group A was given oral ketoconazole dose 200mg daily for 7 days and Group B has given a single dose of 400 mg of itraconazole. 47 (73.4%) male and 17(26.6%) female were included in the study. The mean age of group A was 29.2(SD±8.6) and in group B 28.2(SD±8.5) years. The mean duration of the disease in group A was 3.9(±2.7) months and 3.5(±2.2) months in group B. In group A clinical responders was found cure 25(78.1%), improvement 5(15.6%) and failure in 2(6.2%) and in group B it was found cure 22(68.8%), improvement 7(21.87%) and failure 3(9.4%) at one month. At two months in the group A clinical responder was found to cure 22(68.8%), improvement 5(15.6%), failure in 3(9.4%) and relapse 2(6.2%). In group B it was found cure 18(56.2%), improvement 6(18.75%), failure 4(12.5%) and relapse 4(12.5%). Both oral ketoconazole dose 200mg daily for 7 days versus single dose 400 mg of itraconazole can be effective in the treatment of tinea versicolor with extensive involvement. CBMJ 2020 July: Vol. 09 No. 02 P: 26-33

APLIKASI SISTEM PAKAR DALAM MENDIAGNOSIS PENYAKIT KULIT PADA MANUSIA BERBASIS VISUAL

Health is a blessing that is very important for humans, most of us, many of us don't really care about skin diseases caused by fungi such as tinea versicolor, water fleas, ringworm and scabies. In general, people are quite aware of how to deal with the symptoms of skin diseases suffered. But it would be better to include medical participation in detecting a disease symptom, because many disease symptoms are considered trivial by some people but can be fatal to human skin. So it is necessary to make an application based on medical knowledge to diagnose skin diseases in humans which is used as a tool in obtaining information about skin diseases in humans and provide recommendations as the first action that must be taken to repeat skin diseases in humans. The knowledge base is structured in such a way into a database with several tables. Drawing conclusions in this expert system using the forward chaining inference method. The expert system will provide questions to the user in the form of symptoms of several diseases and the user will answer these questions. Until the user will get a solution from the results of the question earlier.

Novel phytotherapy for tinea versicolor by extracting zingiber wightianum thwaites

Herbal medicines are gaining more interest both in terms of medicinal and economic benefits and they are getting more patient compliance due to its fewer side effects as compared to allopathic medicines. The present research was aimed at phytochemical screening and antifungal evaluation of rhizomic extract of Zingiber wightianum Thwaites belonging to Zingiberaceae family. The rhizomes were subjected for Soxhlet extraction and the preliminary phytochemical screening of this extract proved the presence of alkaloids, carbohydrates, tannins, flavonoids, saponins, phenols. Subsequently, these extracts were evaluated for antifungal activity and minimum inhibitory concentration was determined. Hence revealed the potential to treat a fungal infection Tinea versicolor, caused by fungus Malassezia furfur. This investigation was also undertaken with a view to formulate and evaluate the herbal gel using Zingiber wightianum rhizomic extract. Thus, the overall studies concluded that the rhizomic extract of Zingiber wightianum Thwaites and its formulation would be a breakthrough in the field of modern antifungal drug.

Curiosa pigmentazione cutanea

The case describes a girl with a benign skin condition named Terra Firma-Forme Dermatosis. The Terra Firma-Forme dermatosis is easy to recognize and has an easy resolution but however it has many differential diagnosis as acanthosis nigricans, tinea versicolor confluent and seborrheic keratosis. It is the typical example of “if you know it you recognize it”. A correct diagnosis brings indeed to a prompt resolution and avoids useless and inadequate exams to the patient.

CHROMOPHYTOSIS OVER THE GROIN – AN UNUSUAL PRESENTATION

Pityriasis versicolor is also known as tinea versicolor. It is a common supercial fungal infection of the skin. Clinical features of pityriasis versicolor include either hyperpigmented or hypopigmented ne [1] scaled macules or patches. The most affected sites are the trunk, neck and proximal extremities. It rarely occurs over the groin. It is caused by yeasts of the Malassezia species, commensal of the keratinized layers of the skin which under certain conditions become pathogenic determining the clinical manifestations of the disease. We hereby report a case of Pityriasis versicolor occurring over the groin, a rare presentation.

Can I have epidural analgesia if I have tinea versicolor?

Labor and delivery, while perceived as gratifying and joyful, are nonetheless among the most painful events women can experience in life. Treating pain is nowadays one of the essential elements in assisting women during labor. Epidural analgesia is the best option to ensure the optimal control of pain for the mother without compromising the wellbeing of the fetus. The main contraindications to neuraxial analgesia techniques include patient refusal, known bleeding diathesis or abnormal coagulation tests, elevated intracranial pressure (particularly in the presence of an intracranial space occupying lesion), severe aortic or mitralic valve stenosis and infections at the puncture site [1]. There are many pathogens responsible for cutaneous infections at the dorsal-lumbar level, yeasts of the Malassetia genus being the most commonly implicated. Malassetia Globulosa is the predominant species in the Tinea Versicolor infection [2,3]. Also implicated are M. Sympodialis, M. Furfur and others as well [4]. These fungi are normal components of the cutaneous flora but the transformation from yeasts to micelia can lead to the pathology. The cause for this occurrence is still unknown, yet there are a few contributing factors leading to this infection that affects mostly adolescents and young adults; these are genetic predisposition [5], heat and humidity, immunosuppression, contraceptives, pregnancy and malnutrition. It manifests with characteristic hypo- or hyper-pigmented spots alongside the trunk, the neck, and the face. The majority of the times infection is entirely superficial but cases of meningitis and Central Nervous System (CNS) infections from hematogenous spread have been reported [6,7]. The literature supports with data that adequate antiseptic preparation of the skin effectively prevents meningitis occurrence after epidural puncture [8]; other cases are reported where a small incision of the skin allows for a safer passage of the needle directly in the subcutis without going thnrough the corneal layer.