International Journal of Pharmaceutics and Drug Analysis
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31
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Published By South Asian Academic Publications

2348-8948

Author(s):  
Akwinder Kaur ◽  
Ajeet Pal Singh ◽  
Amar Pal Singh

Objective: Evaluation of anxiolytic and anti-depressant activity of Neolamarckia cadamba in mice. Material & Method: The aqueous and methanolic extract of “Neolamarckia cadamba” and chose low medium and high doses for therapy. The behavioral consequences of an oral acute or subacute (10 days) treatment. Neolamarckia cadamba (250 and 500 mg/kg, p.o) aqueous and methanolic stem bark extract assessed in male and female Swiss mice (EPM). Diazepam (1 mg/kg) will also be evaluated. Anti-anxiety drug testing in the lab. Results: Neolamarckia cadamba,  acute oral toxicity was detected with different extracts (ENC & AQNC) having dose  (5, 50, 300, 1000 mg/kg ) via the oral route,  shows no change in behavioral responses and observation shows no acute oral toxicity. Hence depending upon it, Dose was selected 250 mg/kg & 500 mg/kg for our experimental work. Conclusion: Neolamarckia cadamba has both anxiolytic and antidepressant properties, which likely operate through BZD receptors, selective serotonin reuptake inhibitors. The antidepressant and anxiolytic properties of Neolamarckia cadamba ethanolic and aqueous extracts were investigated in Swiss albino mice at doses of 250 and 500 mg/kg, respectively. Both extracts (ANC & ENC) showed strong antidepressant and anxiolytic efficacy using TST and EPM parameters.


Author(s):  
Lakshmi savithri S ◽  
Geethika Reddy B ◽  
Sushanth Sekhar K ◽  
Durga G ◽  
Srilekha Y ◽  
...  

Transdermal drug delivery system offers best way of drug delivery through skin than compared to oral route of administration by overcoming side-effects.Drug delivery is done through adhesion of transdermal patches to skin surface.Novel application techniques have been employed for better therapeutic response for various drug in treatment of several disease using dermal route of administration.This is best non-invasive method of drug delivery by reducing frequency of administration to achieve complete action of action of drug with maximum benefits to patients .These patches are formulated using various permeation enhancers that are compatible to skins surface .The dermal route of delivery is best suited for therapy to patient for certain diseases.


Author(s):  
Kamalpreet Kaur ◽  
Taranjit Kaur ◽  
Ajeet Pal Singh ◽  
Amar Pal Singh

The improvement of a pure drug's solubility and dissolution rate in the treatment of hyperlipidemia. Simvastatin is a 5-percent absolute bioavailability selective competitive inhibitor of HMG Co-A reductase. For the selection of the carrier, a preliminary solubility investigation of solid dispersion was performed, and solid dispersion was made using Hydroxy Propyl Methyl Cellulose (HPMC) and gum acacia. Solid dispersion of medication with polymer was created and studied for solubility and in-vitro dissolution profile. Solid dispersion of drug with polymer has shown an increase in solubility and improved dissolution rate. On the obtained formulations, further FTIR, X-Ray, Scanning electron microscopy, and Differential scanning calorimetry experiments were conducted. The existence of amorphous form in a solid dispersion made with polymer in a 1:5 ratio is verified by characterization research. The research also showed that using a solid dispersion approach with Polymer, the dissolving rate of a pure medication may be significantly increased.


Author(s):  
Virendra Kumar Singh ◽  
Ramesh Kumar Singh ◽  
Bharat Mishra ◽  
Divyani Singh

A mosquito belongs to the insect-family Culicidae, order Diptera, suborder Nematocera and class Insecta. Mosquito act as vector which carries many disease causing parasites and viruses. Preventing mosquito spread is immensely necessary to stop spread of various contagious diseases. Now days, uses of plant based mosquito repellent have increased as synthetic repellents contains many noxious chemicals which can cause possible toxicity like skin toxicity and causes swelling, redness, itching and many health problems. The herbal mosquito repellent cones were prepared by using saw dust, cow dung, gum acacia, neem powder, eucalyptus powder and lemon grass powder. Lemon grass has insecticidal property. Saw dust increases the combustion. Gum acacia act as binder. Cow dung shows antioxidant and mosquito repellent property. Neem has mosquito repellent property. Herbal mosquito repellent cone were prepared by hand rolling method. The evaluation parameters of herbal mosquito repellent cone contain burning time (min), smoke visibility, odor, irritation test, ash weight (g.) and mosquito repellent activity. The formulation LNC containing lemon grass powder along with neem powder and cow dung in equal ratio shows best activity and maximum effectiveness in reducing mosquito number in comparison with all other formulations. In present study, the powders used in formulation were herbal based and eco-friendly and producing no side-effect on use. Here an attempt has been made to find out the novel formulation of different herbal plant powders containing alone and with combination for mosquito repellent cone.


Author(s):  
V.S. Geethika Timmana ◽  
Glory Mattapalli ◽  
Emmanuel Gujju ◽  
Priyanka Boddu ◽  
Uma Sankar V

Background:  Menopause is a  phase of transformation from the reproductive to the non-reproductive period in a woman’s life. In the aging population it is nature’s defensive event against reproductive morbidity and mortality.“An individual’s insight of their position in conditions such as the value and culture systems in which they survive and in relation to their goals, expectations, standards and concerns” in life is defined as QOL. A negative effect on the common health and quality of life (QOL) as well as the contentment of middle-aged women may occur due to Menopause and associated biologicals. Objective: To evaluate the quality of life and postmenopausal symptoms in postmenopausal women. Methods: In this present study 100 patients were recruited and studied for their demographic details and their postmenopausal qualityof life related aspects. The obtained data was analysed using the SPSS software. Results: The mean menopausal age was found to be 45.6 years. The maximum and minimum menopausal ages were 37 and 60 respectively in this study. On analysis, MSQOL revealed that 89% women suffered sexual symptoms, followed by 78% women who suffered physical symptoms like decrease in physical strength and stamina, aches in back of neck and head, aching muscles and joints. Approximately half of the women experienced vasomotor and psychological symptoms. UQOL revealed lower or poor QOL of the postmenopausal women. The overall average scores for occupational, health, emotional, sexual and total QOL for 100 participants was found to be 11.37, 21.03, 17.84, 3.67 and 53.34 respectively


Author(s):  
Rishitha Reddy P ◽  
Prathul P ◽  
Jayalakshmi A ◽  
Anusha SB ◽  
Randeep Raj V.C

Background: Cardiovascular and cerebrovascular diseases were becoming predominant cause of morbidity and mortality in India. Antiplatelet agents remain as the cornerstone therapy for acute thrombotic coronary syndromes, IHD, STROKE, CHD and PCI and are essential for thromboprophylaxis. The current study was undertaken to evaluate the drug use pattern of antiplateletagents and to study the prescribing pattern, observe co-morbid conditions, social habits [alcohol/smoking], adverse events and drug-drug interactions associated with antiplatelet agents. Methods: A prospective observational study was conducted at MIMS hospital, study population of 160 inpatients from cardiology, general-medicine and neurology departments. Data was analyzed in Microsoft excel. Results: Data records obtained from 160 patients in which 51.87% were females followed by males 48.125%. most patients with IHD and stroke were found in age group 50-70 years. Hypertension was most found co-morbidity among the patients [61.88%] followed by diabetes [34.38%], hypothyroidism [5%], epilepsy[3.75%]. Utilisation pattern of antiplatelet agents aspirin, clopidogrel were found to be[97.5%] [82.5%] respectively. patients on DAPT[81%] were highest compared to monotherapy [19%]. Patients found with social habits were 38.75% smokers, 31.25% alcoholics and 22% both alcohol and smoking. Conclusion: The present study concludes that DAPT [aspirin+clopidogrel] was found to be superior to monotherapy, and incidence of IHD which is more common in males compared to females. Patients in the group 51-70 were most affected with stroke, IHD and with female predominance over male. Antiplatelet therapy which is clearly efficacious in reducing the incidence of ischemic events/ thromboembolic events DAPT[aspirin+ clopidogrel] was most effective and reduced ischemic events, yet have the risk of bleeding or resistance. Newer anti platelet agents such a Prasugrel and Ticagrelor can be utilised considering the bleeding risk.


Author(s):  
Grishma H Patel ◽  
Shreya D Adeshra ◽  
Dhananjay B Meshram

A Novel, selective, accurate and rapid Reversed Phase High Performance Liquid Chromatographic (RPHPLC) method for the analysis of Efonidipine Hydrochloride Ethanolate and Telmisartan in binary mixture has been developed and validated. The chromatographic system consisted of a Phenomenex Kinetex ® 5µ C18 Size: 150 * 4.6mm column and the separation was achieved by using ambient temperature with a mobile phase containing mobile Phase Acetonitrile:25mM Phosphate Buffer pH 4.9 (45:55). The samples were monitored at 253 nm for detection at a flow rate of 1.0 mL/min and the retention time was about 7.77 and 4.10 mins for Efonidipine Hydrochloride Ehanolate and Telmisartan respectively. The calibration curve was linear over the concentration range 5-30 and 10-60 ?g/mL for Efonidipine Hydrochloride Ehanolate and Telmisartan respectively. The proposed method is accurate in the range of 99.75% - 100.10% recovery and precise (%RSD of intraday variation and % RSD of inter day variation were found to be within the acceptance criteria). Therefore, this method can be used as a more convenient and efficient option for the analysis of Efonidipine Hydrochloride Ehanolate and Telmisartan in Quality control laboratory.


Author(s):  
Lakshmi savithri S ◽  
Veda sravanthi A ◽  
Shakeena D ◽  
Selophy R ◽  
Pushpalatha M ◽  
...  

Aloe Vera is a natural product which is now a days used in the field of cosmetology. Our formulation is to formulate a herbal shampoo using a plant extract which is used as hair washing and conditioning shampoo to treat hair loss and prevent itching scalp and dandruff. is effective than the marketed shampoo as we have used essential oils like coconut oil which is derived from the coconut palm fruit , lavender oil which is derived from the flowers of lavender, rosemary oil derived from the flowering tops of rosemary. eucalyptus oil which is derived from the leaves of eucalyptus plant and some other excepients  like antioxidants stabilizers,  solubilizing agents, surfactants, cleansing agents, coloring agents and preservatives. All of these are used for the aim to improve the smoothening , shining and growth of the hair. Our study has evaluated all the tests like foaming ability test, pH determination, skin irritancy test, conditioning performance, wettability and in all those test it has shown good results when compared to the marketed shampoo.


Author(s):  
Jyothi K Navya ◽  
Prameela Jogi ◽  
C.Randeep raj V

According to ICH GCP investigator may be considered as a person proficient in education, training, and experience who will take the major restraint for the good conduct of the trial and should satisfy all the requirements described by applicable regulatory authorities and must comply with GCP. Investigators are very much important for the primary conduct of the study, whose primary importance is to conduct research while protecting the rights, safety, and well-being of the participants. Investigators have many important roles in conducting ethical research, taking responsibility for the informed consent process, giving the statement of the investigator, checking of investigational product, reporting adverse events, maintaining accurate records. A selection of the investigator for the conduct of research is a complex process. Investigators should be selected based on their interest and their requirements for education, training, and experience. This can be done by assessing professional competency or through a referral from other investigators or through online databases or by advertising their CV on the internet. In multicenter trials selection is done by querying public and private, using databases, a referral from the clinical research team, performing a publication search. After the recruitment of Investigators, he will continue his activities like signing the investigators' form and perform the informed consent process, and finally enrollment of subjects. The Investigators involved in COVID-19 trials and the study type, recruitment status, purpose of the trial was collected. 


Author(s):  
Jaspreet Kaur ◽  
Amar Pal Singh ◽  
Ajeet Pal Singh ◽  
Rajinderpal Kaur

The White Fungus, which causes white rot on tree trunks, belongs to the basidiomycetes. Research into the microbiology of White-rot fungi has focused on engineering processes related to factors such as cell growth and enzyme production processes, and to smaller, i.e., molecular biology. Many studies have been conducted to select issues with high or specific biodegradation performance in a variety of ways. Production inhibitors have been used to improve enzyme production. Investigators are investigating different carriers (Stainless Steel net, polyamide fiber net, fiberglass net and polyurethane foam) to impair P.chrysosporium ligninolytic enzyme production. In this review, Pathophysiology, Microbiology, impact factors, treatments and alternative uses show white mold formation in biotransformation. The white fungus is being investigated to produce biotechnology for the reduction of a broad spectrum, a natural pollutant based on lignin-deficient enzymes. This in particular covers the destruction of many wastes and environmental pollution, including wastewater, pesticides, toxic natural pollutants, chlorinated hydrocarbons, etc. It will be updated.


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