PVP-Gold-copper Nanocluster Based NIR Fluorescence Probe for Sensitive Detection of Malachite green

Malachite green (MG) is considered an environmental contaminant because of its properties of antifungal, carcinogenic and teratogenic. The existing detection methods of MG are complex, costly and laborious. In this...

Cadmium, an Environmental Contaminant, Exacerbates Alzheimer’s Pathology in the Aged Mice’s Brain

Cadmium (Cd) is an environmental contaminant, which is a potential risk factor in the progression of aging-associated neurodegenerative diseases. Herein, we have assessed the effects of chronic administration of Cd on cellular oxidative stress and its associated Alzheimer’s disease (AD) pathologies in animal models. Two groups of mice were used, one group administered with saline and the other with Cd (1 mg/kg/day; intraperitoneally) for 3 months. After behavioral studies, molecular/biochemical (Immunoblotting, ELISAs, ROS, LPO, and GSH assays) and morphological analyses were performed. We observed an exacerbation of memory and synaptic deficits in chronic Cd-injected mice. Subacute and chronic Cd escalated reactive oxygen species (ROS), suppressed the master antioxidant enzymes, e.g., nuclear factor-erythroid 2-related factor 2 and heme oxygenase-1, and evoked the stress kinase phospho-c-Jun N-terminal kinase 1 signaling pathways, which may escalate AD pathologies possibly associated with amyloidogenic processes. These findings suggest the regulation of oxidative stress/ROS and its associated amyloid beta pathologies for targeting the Cd-exacerbated AD pathogenesis. In addition, these preclinical animal studies represent a paradigm for epidemiological studies of the human population exposed to chronic and subacute administration of Cd, suggesting avoiding environmental contaminants.

RARE CAUSE OF BACTERAEMIA: MICROBACTERIUM ARBORESCENS.

Microbacterium arborescens, among coryneform bacteria are gram positive rods with orange pigmented colonies. Usually these are environmental contaminant but has shown invasive potential in immunocompromised individuals.A 56 yrs old lady presented with uncontrolled hyperglycaemia and hypertension. M. arborescens was isolated on blood culture. Identication was done based on biochemical characterictics and conrmed by Matrix assisted light desorption ionisation Time of Flight Mass Spectrometry( MALDI TOFF MS). Further amplication and sequencing was done and phylogenetic tree was contructed. Tree clearly shows clinical strain PGI 2 is different from environmental strain