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Bioactive peptides (BPs) are peptides with hormonal or pharmacological properties. They play a key role in
growth, metabolism, disease, aging and death by affecting digestion, endocrine, cardiovascular, immune and nervous
systems. They show potential therapeutic effect on blood pressure-lowering (ACE inhibitory), anticancer, antithrombotic,
antibacterial, anti-inflammatory, antioxidant, antiobesity, anti-genotoxic and immunomodulatory. Companied by the fast
development and wide applications of DNA sequencing method, a wealth of bioactive peptide sequences accumulated
through empirical and bioinformatics approaches or an integrated approach. To store and facilitate the usage of bioactive
peptide data, a series of databases have been established that concerned about different aspects of BPs. A variety of
information including sequence, source, biological activity, toxicity, physical-chemical property, and structure is stored in
these databases. This review summarizes the latest development of BPs databases and briefly introduces the
characteristics of different databases, as to help readers to retrieve the required information more easily. In addition, it also
includes sequence analysis, structural simulation and activity prediction tools, which may be helpful for the design and
discover of new bioactive peptides.