Antigen-Specific Urinary Immunoglobulin in Reservoir Hosts of Leptospirosis

Domestic and wildlife animal species act as reservoir hosts of leptospirosis, a global zoonotic disease affecting more than 1 million people annually and causing significant morbidity and mortality in domestic animals. In contrast to incidental hosts which present with an array of clinical manifestations, reservoir hosts are typically asymptomatic and can shed leptospires from chronically infected kidneys via urine for extended periods of time. Renal excretion of leptospires occurs despite evidence of a humoral and cellular immune response and is reflective of the unique biological equilibrium that exists between certain animal species and specific serovars of Leptospira. Here, we demonstrate that urinary excretion of leptospires is accompanied by the presence of antigen-specific urinary immunoglobulin. In rats experimentally infected with L. interrogans serovar Copenhageni using the intraperitoneal or conjunctival route of inoculation, urinary immunoglobulin (Ig) G specific for protein antigens was detectable within 1 week. Rat urinary IgG was not bound to urinary-derived leptospires. In cattle that were naturally exposed to, and infected with, L. borgpetersenii serovar Hardjo, urinary IgA specific for protein antigens was detected. Collectively, these results demonstrate that urinary excretion of immunoglobulin specific for leptospires is a hallmark of reservoir hosts of infection.

Analisis dinamik model predator-prey tipe Gause dengan wabah penyakit pada prey

This article studies the dynamics of a Gause-type predator-prey model with infectious disease in the prey. The constructed model is a deterministic model which assumes the prey is divided into two compartments i.e. susceptible prey and infected prey, and both of them are hunted by predator bilinearly. It is investigated that there exist five biological equilibrium points such as all population extinction point, infected prey and predator extinction point, infected prey extinction point, predator extinction point, and co-existence point. We find that all population extinction point always unstable while others are conditionally locally asymptotically stable. Numerical simulations, as well as the phase portraits, are given to support the analytical results.

Analysis of a Prey-Predator Fishing Model for Harvesting with The Limited Effect of Density and Toxicity

We proposed a model of prey-predator fishing by considering proportion of prey density and toxicity in ecosystem. The model is analysed to study about biological equilibrium, bionomic equilibrium and its stability. The aim of the model is to determine the optimal sustainable harvesting for each species. The optimal harvesting is resulted from Pontryagin’s maximal principle. The global stability of coexistence equilibrium is analyzed from Lyapunov function. The effect of toxicity leads to the decreasing of sustainable harvesting.

Fish and broiler optimal harvesting models in imprecise environment

In this paper, a two-species harvesting model has been considered and developed a solution procedure which is able to calculate the equilibrium points of the model where some biological parameters of the model are interval numbers. A parametric mathematical program is formulated to find the biological equilibrium of the model for different values of parameters. This interval-valued problem is converted into an equivalent crisp model using interval mathematics. The main advantage of the proposed procedure is that different characteristics of the model can be presented in a single framework. Analytically, the existence of steady state and stabilities are looked into. Using mathematical software, the model is illustrated and the results are obtained and presented in tabular and graphical forms.

Stability analysis of combined project of fish, broiler and ducks: Dynamical system in imprecise environment

In this paper, we consider three species harvesting model and develop a solution procedure which is able to calculate the equilibrium points of the model where some biological parameters of the model are interval numbers. A parametric mathematical program is formulated to find the biological equilibrium of the model for different values of parameters. This interval-valued problem is converted into equivalent crisp model using interval operations. The main advantage of the proposed procedure is that we can present different characteristics of the model in a single framework. Analytically, the existence of steady state and stabilities are looked into. Using mathematical software, the model is illustrated and the results are obtained and presented in tabular and graphical forms.

Multicentric caries prevention program: Mechanical control of dental plaque through periodic professional oral prophylaxis. A 10 years follow up

AIM: To verify the incidence of dental caries in a multicentric prevention program applied in pediatric dentistry clinics from different regions of Brazil for 10 years, and compare with results obtained by previous studies. MATERIAL AND METHODS: 697 children of both genders, ranging from 30 months to 15 years, were included in a primary preventive strategy program for mechanical control of dental plaque through professional prophylaxis (sodium bicarbonate jet on a monthly schedule). Diagnosis of carious lesions was assessed by monthly clinical examinations and annual radiographs. This procedure aimed to provide a biological equilibrium without producing undesirable side effects. RESULTS: The average age of children at beginning of the program was 81.71 months. Before entering the program the children presented an average of 2.66 lesions/surface, while during the program the average was 0.20 lesions/surface; the incidence rate of caries per year before starting the program was on average 0.62 lesions/surface while during the program it was 0.05 lesions/surface; the time of permanence in the program was on average 44.15 months and the absence rate was 0.14 per year. CONCLUSION: The results confirm the effectiveness of the program, even when applied by different professionals and in different groups of children, turning it into an indispensible method for the control of dental caries.

Non-equilibrium transition state rate theory

Transition state or Kramers' rate theory has been used to quantify the kinetic speed of many chemical, physical and biological equilibrium processes successfully.

UJI AKTIVITAS EKSTRAK BUAH MERAH (Pandanus conoideus) SEBAGAI HEPATOPROTEKTOR PADA HATI MENCIT GALUR SWISS YANG DIINDUKSI DENGAN CCl4

Liver is an the important organ, it plays an essential role in maintaining the biological equilibrium of vertebrates. Reactive oxygen species (ROS) play an important role in pathological changes in the liver. The research has been carried out to know the potential use of buah merah (Pandanus conoideus) extract as hepatoprotrctive agent against CCl4 poisoning in mice. In this study, the hepatoprotective activity was determined by the reduction of SGPT (serum glutamic pyruvate transaminase) and SGOT (serum glutamic oxaloacetic transaminase) level. Application of buah merah extract significantly (p< 0,05) reduced SGPT and SGOT level. Microscopically, several changes were found, such as severe hydrofic degeneration and necrosis at liver cell that treated by CCl4. Base on histological examination of application of buah merah extract, could inhibit damage and reduced the degeneration and necrosis of liver cell. Keywords: buah merah, SGPT, SGOT, hepatoprotective.