scholarly journals UJI AKTIVITAS EKSTRAK BUAH MERAH (Pandanus conoideus) SEBAGAI HEPATOPROTEKTOR PADA HATI MENCIT GALUR SWISS YANG DIINDUKSI DENGAN CCl4

2010 ◽  
Vol 1 (1) ◽  
Author(s):  
Arina Swastika Maulita
Keyword(s):  
Liver Cell ◽  
Transaminase Level ◽  
Hepatoprotective Activity ◽  
Oxygen Species ◽  
Glutamic Oxaloacetic Transaminase ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Ccl4 Poisoning ◽  
Serum Glutamic Pyruvate Transaminase ◽  
Potential Use ◽  
Biological Equilibrium

Liver is an the important organ, it plays an essential role in maintaining the biological equilibrium of vertebrates. Reactive oxygen species (ROS) play an important role in pathological changes in the liver. The research has been carried out to know the potential use of buah merah (Pandanus conoideus) extract as hepatoprotrctive agent against CCl4 poisoning in mice. In this study, the hepatoprotective activity was determined by the reduction of SGPT (serum glutamic pyruvate transaminase) and SGOT (serum glutamic oxaloacetic transaminase) level. Application of buah merah extract significantly (p< 0,05) reduced SGPT and SGOT level. Microscopically, several changes were found, such as severe hydrofic degeneration and necrosis at liver cell that treated by CCl4. Base on histological examination of application of buah merah extract, could inhibit damage and reduced the degeneration and necrosis of liver cell. Keywords: buah merah, SGPT, SGOT, hepatoprotective.

scholarly journals Hepatoprotective Effects of Chai-Hu-Ching-Kan-Tang on Acetaminophen-Induced Acute Liver Injury in Rats

2007 ◽  
Vol 35 (01) ◽  
pp. 69-79 ◽  
Author(s):  
Tzu-Hsiang Lin ◽  
Lean-Teik Ng ◽  
Feng-Lin Yen ◽  
Chun-Ching Lin
Keyword(s):  
Liver Injury ◽  
Liver Diseases ◽  
Acute Liver Injury ◽  
Lipid Peroxides ◽  
Hepatoprotective Activity ◽  
Glutamic Pyruvic Transaminase ◽  
Glutamic Oxaloacetic Transaminase ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Hepatoprotective Agent ◽  
Hepatoprotective Effects

Chai-Hu-Ching-Kan-Tang (CHCKT) is one of the traditional Chinese medicine prescriptions commonly used to treat liver diseases. In this study, we evaluated the hepatoprotective effects of aqueous CHCKT extract at various concentrations (125, 250 and 500 mg/kg body weight) on acetaminophen (APAP)-induced acute liver injury in rats. Results showed that CHCKT treatments significantly decreased the level of serum glutamic oxaloacetic transaminase (sGOT) and glutamic pyruvic transaminase (sGPT) in APAP-treated groups. CHCKT also significantly decreased the level of lipid peroxides and increased the activity of antioxidant enzymes (i.e. SOD and GPx). Histopathological observation further confirmed the hepatoprotective activity of CHCKT as indicated by the amelioration in the central necrosis and fatty changes of the liver after APAP induction. Interestingly, the hepatoprotective activity of CHCKT at concentrations 125~500 mg/kg appeared to be as good as 12.5 mg/kg silymarin (a commercial hepatoprotective agent). Taken together, these results suggest that aqueous extract of CHCKT possesses potent hepatoprotective effects agianst APAP-induced liver injury in rats.

Hepatoprotective and antioxidant effect of Adiantum lunulatum Burm. F. leaf in alcohol-induced rat model

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Nimisha Parshottambhai Kakadia ◽  
Monika A Amin ◽  
Shrikalp S Deshpande
Keyword(s):  
Total Bilirubin ◽  
Antioxidant Activities ◽  
Ethanolic Extract ◽  
Hepatoprotective Activity ◽  
Antioxidant Effect ◽  
Serum Enzymes ◽  
Glutamic Oxaloacetic Transaminase ◽  
Serum Glutamic Pyruvic Transaminase ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Experimental Animals

ABSTRACTBackgroundAdiantum lunulatum Burm. F. leaf (AL) and its related species have been used traditionally for the treatment of various diseases.ObjectiveThe present study evaluated the hepatoprotective, and antioxidant activities of ethanolic extract of AL.Methodology and ResultThe hepatoprotective effect of AL was evaluated against ethanol-induced hepatotoxicity in rats. Administration of ethanol (2 g/kg) showed a significant biochemical and histological deterioration in the liver of experimental animals. Pretreatment with ethanolic extract of AL (250 and 500 mg/kg b.wt. p.o) significantly reduced the elevated levels of serum enzymes like serum glutamic-oxaloacetic transaminase (AST), serum glutamic-pyruvic transaminase (ALT), alkaline phosphatase (ALP), total protein, total bilirubin and reversed the hepatic damage in the liver which evidenced the hepatoprotective activity. The superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) level notably increased due to doses of AL.ConclusionThe results of the present study demonstrate that the ethanolic extract of AL possesses hepatoprotective and antioxidant activities.Graphical Abstract

Bergenin Exhibits Hepatoprotective Activity Against Ethanol-Induced Oxidative Stress in ICR Mice

2019 ◽  
Vol 18 (4) ◽  
pp. 297-302
Author(s):  
Sriset Yollada ◽  
Chatuphonprasert Waranya ◽  
Jarukamjorn Kanokwan
Keyword(s):  
Reactive Oxygen Species ◽  
Gallic Acid ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Hepatic Injury ◽  
Reduced Glutathione ◽  
Reactive Oxygen ◽  
Hepatoprotective Activity ◽  
Oxygen Species ◽  
Hepatic Glutathione

Bergenin is a C-glucoside derivative of gallic acid but its antioxidant and hepatoprotective effects have not previously been compared with gallic acid. Male ICR mice were administered bergenin (10, 50, and 250 mg/kg/day) or gallic acid (100 mg/kg/day) for 7 consecutive days before a single administration of ethanol (5 g/kg). Liver sections were histopathologically examined. Aspartate aminotransferase, alanine aminotransferase, reactive oxygen species, and malondialdehyde levels were determined in plasma. Total glutathione, reduced glutathione, and oxidized glutathione levels were determined in liver homogenates. Ethanol induced hepatic injury with prominent histopathological markers including nuclear pyknosis and necrotic areas and this accorded with increases in the plasma levels of aspartate aminotransferase, alanine aminotransferase, reactive oxygen species, and malondialdehyde. Moreover, ethanol disturbed hepatic glutathione homeostasis by reducing glutathione stores. Hepatic injury in the ethanol-induced mice was prevented with bergenin and gallic acid by significant decreases in plasma aspartate aminotransferase, alanine aminotransferase, reactive oxygen species, and malondialdehyde levels and restoration of the hepatic glutathione profile through an increase in the reduced glutathione/oxidized glutathione ratio. Bergenin at 10 mg/kg/day showed comparable hepatoprotective activity to gallic acid in an ethanol-induced mouse model of oxidative stress. Therefore, bergenin might be a promising candidate for further development as a novel hepatoprotective product.

scholarly journals Clinical and therapeutic correlations in patients with slight acute pancreatitis

2015 ◽  
Vol 28 (1) ◽  
pp. 24-27 ◽  
Author(s):  
Clewis Henri MUNHOZ-FILHO ◽  
Fernando BATIGÁLIA ◽  
Hamilton Luiz Xavier FUNES
Keyword(s):  
Acute Pancreatitis ◽  
Intensive Care ◽  
Vital Signs ◽  
Positive Association ◽  
Multiple Organ ◽  
Glutamic Oxaloacetic Transaminase ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Early Return ◽  
Lower Spectrum ◽  
Mild Acute Pancreatitis

BACKGROUND: Acute pancreatitis is an inflammatory disease of the pancreas due to enzymatic autodigestion which can cause necrosis or multiple organ failure; its pathophysiology is not fully known yet. AIM: To evaluate the correlation between clinical and therapeutic data in patients with mild acute pancreatitis. METHODS: A retrospective study in 55 medical records of patients admitted with acute mild pancreatitis was realized to analyze the association between age, leukocytosis, serum glutamic-oxaloacetic transaminase and lactate dehydrogenase, glucose, antibiotics, time admission and Ranson´s scores. RESULTS: There was a positive association between less intensive care (strict hydration, analgesia and monitoring of vital signs), early antibiotic therapy (monotherapy), early return to diet after 48 hours and laboratory control of the serum amylase and lipase (high in the first week and decreasing after 10 days, without any prognostic value). CONCLUSIONS: Changes in the management of patients with mild acute pancreatitis, such as enteral nutrition, rational use of lower spectrum antibiotics and intensive care, have contributed significantly to the reduction of hospitalization time and mortality.

scholarly journals PENGARUH AKTIFITAS FISIK CONTINUOUS RUNNING DAN INTERVAL RUNNING TERHADAP SERUM GLUTAMIC OXALOACETIC TRANSAMINASE (SGOT) DAN SERUM GLUTAMIC PYRUVIC TRANSAMINASE (SGPT)

2019 ◽  
Vol 3 (1) ◽  
pp. 12
Author(s):  
Novita Sari Harahap ◽  
Riski Pranata
Keyword(s):  
Glutamic Pyruvic Transaminase ◽  
Glutamic Oxaloacetic Transaminase ◽  
Serum Glutamic Pyruvic Transaminase ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Group Design ◽  
Continuous Running

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh aktifitas fisik continuous running dan interval running terhadap SGOT dan SGPT pada mahasiswa Ikor Unimed Tahun 2017. Penelitian dilakukan di Stadion Universitas Negeri Medan, Laboratorium Fisik FIK, dan Laboratorium Kesehatan Daerah Dinas Kesehatan Provinsi Sumatera Utara. Metode penelitian yang digunakan dalam penelitian ini adalah metode eksperimen. Sampel penelitian menggunakan mahasiswa Ikor Unimed  sebanyak 14 orang. Desain penelitian menggunakan Pretest-Posttest Group Design. Aktifitas fisik continuous Running dan interval running dilakukan dengan menggunakan Treadmill selama 12 menit dengan intensitas 60-70 %. Pemeriksaan kadar SGOT dan SGPT dilakukan di awal dan di akhir perlakuan. Teknik analisis data pada penelitian ini menggunakan uji t.  Hasil penelitian menunjukkan  bahwa peningkatan rerata kadar SGOT setelah aktifitas fisik continuous running sebesar 88,00 U/L yang sebelumnya sebesar 60,89 U/L dan setelah aktifitas fisik interval running sebesar 81,61 U/L yang sebelumnya 60,41 U/L. Hasil uji analisis diperoleh nilai p=0,662, yang menunnjukkan bahwa ada peningkatan namun tidak terdapat perbedaan yang bermakna p>0,05. Begitu juga dengan rerata kadar SGPT setelah aktifitas fisik continuous running sebesar 82,21 U/L yang sebelumnya sebesar 57,16 U/L dan setelah aktifitas fisik interval running sebesar 81,80 U/L yang sebelumnya 59,59 U/L. Hasil uji analisis diperoleh nilai p=0,655, yang menunnjukkan bahwa ada peningkatan namun tidak terdapat perbedaan yang bermakna p>0,05. Penelitian ini menyimpulkan bahwa bahwa tidak terdapat perbedaan yang bermakna antara aktifitas fisik continuous running dan aktifitas fisik interval running terhadap peningkatan SGOT dan SGPT pada mahasiswa IKOR UNIMED tahun 2017.Kata kunci: Continuous Running, Interval Running, SGOT dan SGPT

scholarly journals Applications of Oxygen-Carrying Micro/Nanobubbles: a Potential Approach to Enhance Photodynamic Therapy and Photoacoustic Imaging

2018 ◽  
Author(s):  
M. Saad Khan ◽  
Jangsun Hwang ◽  
Kyungwoo Lee ◽  
Yonghyun Choi ◽  
Kyobum Kim ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oxygen Supply ◽  
Photoacoustic Imaging ◽  
Supply And Demand ◽  
Flexible Structures ◽  
Synthesis Methods ◽  
Oxygen Species ◽  
Hypoxic Conditions ◽  
Potential Use ◽  
Resistance To Chemotherapy

Microbubbles and nanobubbles can be prepared using various shells, such as phospholipids, polymers, proteins, and surfactants. They are echogenic and can be used as contrast agents for ultrasonic and photoacoustic imaging. These bubbles can be engineered in various sizes as vehicles for gas and drug delivery applications with novel properties and flexible structures. Hypoxic areas in tumors develop owing to an imbalance of oxygen supply and demand. In tumors, hypoxic regions have shown more resistance to chemotherapy, radiotherapy, and photodynamic therapies. The efficacy of photodynamic therapy depends on the availability of oxygen in the tumor to generate reactive oxygen species. Micro/nanobubbles have been shown to reverse hypoxic conditions and increase tissue oxygen levels. This review summarizes the synthesis methods and shell compositions of micro/nanobubbles and methods deployed for oxygen delivery. In addition, the shortcomings and prospects of engineering micro/nanobubbles are discussed for their potential use in photodynamic therapy.

scholarly journals Effect of Cardiac Catheterization and Angiocardiography on the Serum Glutamic Oxaloacetic Transaminase

Circulation ◽  
1963 ◽  
Vol 27 (4) ◽  
pp. 565-570 ◽  
Author(s):  
ZAVEN A. ADROUNY ◽  
MAX J. STEPHENSON ◽  
KURT R. STRAUBE ◽  
CHARLES T. DOTTER ◽  
HERBERT E. GRISWOLD
Keyword(s):  
Cardiac Catheterization ◽  
Glutamic Oxaloacetic Transaminase ◽  
Serum Glutamic Oxaloacetic Transaminase

COMPARATIVE EVALUATION OF IN VITRO ANTIOXIDANT AND IN VIVO HEPATOPROTECTIVE ACTIVITIES OF ETHANOLIC LEAF AND ROOT EXTRACTS OF CLEOME GYNANDRA

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (04) ◽  
pp. 50-56
Author(s):  
K Ravishankar ◽  
Y.V.V.M. Lakshmi Prasanna ◽  
G.V.N. Kiranmayi ◽  
Keyword(s):  
Carbon Tetrachloride ◽  
Hepatoprotective Activity ◽  
Root Extract ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Root Extracts ◽  
Cleome Gynandra ◽  
Ic50 Values ◽  
Ethanolic Leaf Extract

In vitro antioxidant and in vivo hepatoprotective activities of Cleome gynandra ethanolic leaf and root extracts were assessed. In vitro antioxidant activity was carried by DPPH, Nitric oxide, hydroxyl radical and phosphomolybdenum assays. Hepatoprotective activity was evaluated by Carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats.The animals were divided into seven groups (Four test groups - Ethanolic Leaf and Root Extracts of Cleome gynandra of 100 mg/kg and 200 mg/kg, standard silymarin (100 mg/kg), toxic control-carbon tetrachloride and vehicle). On the eight day, the blood was collected and parameters like serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), Alkaline phosphatase (ALP) and Total bilirubin (TB) were estimated. Significant antioxidant status with good IC50 values similar to standard ascorbic acid was obtained. A significant decrease in liver enzymes was observed in test groups comparable to silymarin. From the results obtained, ethanolic leaf extract has contributed better hepatoprotection compared with root extract in experimental rats.

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