AutoCell Systematic Evolution of Ligands by Exponential Enrichment: The Software Designed and Developed for the Automated Screening System of Nucleic Acid Aptamers

Aptamers are a new kind of nano-probes for bioassays and drug delivery, etc. In this paper, software has been developed as an automatic control center for the automated aptamer selecting system which realized the high integration of aptamer selection, data acquisition and processing. This software, applied in windows system, is developed by C# with the Microsoft Visual Studio 2015 integrated developing environment and the database used in this software is implemented using open source relational database MYSQL. According to the requirement analysis, this software realized various important necessary functions including feasible experiment design, auto-control of the hardware, real time process monitoring and efficient data management which perfectly satisfies the users’ demands. During the actual experiment operation, this software worked smoothly and assumed stable serial port communication between it and the hardware, meanwhile, the interaction between the software and MYSQL remained good stability. As a consequence, it is practical and reasonable to apply this software to the automated aptamer selecting system for research.

The infectious vaccines against SARS-CoV-2 already exist

In allusion to the COVID-19 epidemic situation, the current key point to win the decisive victory is on how to improve the antibody prevalence, so as to achieve herd immunity and eventually eliminate the epidemic situation. Therefore, it is strongly recommended that an authoritative experimental conclusion should be given on whether the recovered patients with COVID-19 are infectivity or not. That is to say, those susceptible people who have not yet had the antibodies should be tested, in order to verify whether they would produce antibodies after close contact with the recovered patients who have had the antibodies. Of course, this is a feasible experiment. The implication that there should be a type of infectious vaccines against SARS-CoV-2, which is always around us and well within reach. In addition, it is pointed out that the state of balance where the viruses and the human immune system are opposed and can coexist is the environment they face for survival and proliferation, while the infectivity is the necessary condition. It is under such environment that the progenies of those original viruses would be just possible to be improved by human immune system, thereby evolve into the main part of the IgG antibodies. Since asymptomatic infected persons are now confirmed to transmit the viruses, so it is inferred that the Infectious Attenuated Live Vaccine against SARS-CoV-2 must be there too.

Entropy and geometry of quantum states

We compare the roles of the Bures–Helstrom (BH) and Bogoliubov–Kubo–Mori (BKM) metrics in the subject of quantum information geometry. We note that there are two limits involved in state discrimination, which we call the “thermodynamic” limit (of [Formula: see text], the number of realizations going to infinity) and the infinitesimal limit (of the separation of states tending to zero). We show that these two limits do not commute in the quantum case. Taking the infinitesimal limit first leads to the BH metric and the corresponding Cramér–Rao bound, which is widely accepted in this subject. Taking limits in the opposite order leads to the BKM metric, which results in a weaker Cramér–Rao bound. This lack of commutation of limits is a purely quantum phenomenon arising from quantum entanglement. We can exploit this phenomenon to gain a quantum advantage in state discrimination and get around the limitation imposed by the Bures–Helstrom Cramér–Rao (BHCR) bound. We propose a technologically feasible experiment with cold atoms to demonstrate the quantum advantage in the simple case of two qubits.

Experiment Research on Single Step Mixing at Low Temperature

On the basis of reading a large number of literatures and collecting information, this article provides an experiment research on the single step mixing at low temperature. According to the principle of the single step mixing at low temperature, the feasible experiment platform is designed and several important technological parameters are selected; and the experiment is conducted adopting the orthogonal experiment, and the best technological parameters have been finally found out.

Creating high-dimensional time-bin entanglement using mode-locked lasers

We present a new scheme to generate high dimensional entanglement between two photonic systems. The idea is based on parametric down conversion with a sequence of pump pulses generated by a mode-locked laser. We prove experimentally the feasibility of this scheme by performing a Franson-type Bell test using a 2-way interferometer with path-length difference equal to the distance between 2 pump pulses. With this experiment, we can demonstrate entanglement for a two-photon state of at least dimension D=11. Finally, we propose a feasible experiment to show a Fabry-Perot like effect for a high dimensional two-photon state.

Low-frequency vibrations of helical structures in protein molecules

A physically intuitive and mathematically easily handled formula is presented for calculating the low-frequency vibrations of helical structures in protein molecules. alpha-Chymotrypsin is taken as an example, and the calculated result shows precise agreement with observations of the low-frequency Raman spectra. As reflected in the formula, this kind of low frequency is very sensitive to the conformation of a biomacromolecule, and can therefore serve as a vehicle to investigate the mechanism of action of a biomacromolecule from the viewpoint of dynamics. On this basis a feasible experiment is suggested by which one can examine the relationship between a presumed mode of low-frequency vibration in a biomacromolecule and its activity.