Games have impacted education, research, and industry in multiple ways, altering notions of interaction. Traditionally, instructional design and educational research have dominated academic studies of pedagogy, teaching, and training. There are many parallels between the fields of game design and education, as both draw inspiration from the study of engagement, interaction, and motivation. State-of-the-art research and trends show great potential to cross-pollinate and uplift each area. This chapter synthesizes instructional and game design concepts based on current research, comparing and contrasting key elements. Towards the goal of providing a road map for readers, the chapter demonstrates three active case studies that illustrate how both fields greatly influence each other, leading to positive outcomes. These cases demonstrate that many concepts in both fields have direct parallels. The chapter concludes with a discussion of potential future directions and trends.