Chapter 2 describes the foundational research from which it is based and introduces the main outline and goals of culturally informed therapy for schizophrenia (CIT-S). The chapter begins by introducing the history of family therapy for people with schizophrenia, its empirical support, and the cultural gaps that limited its generalizability in early clinical trials. Notable predictors of wellness (e.g., expressed emotion, collectivism, religion/spirituality, and ethnic pride) are reviewed, and relevant cultural differences are explored. The research reviewed provides the framework for the five modules of CIT-S (family collectivism, psychoeducation, spirituality, communication training, and problem-solving) and its session structure. Clinicians are encouraged to not only build their own knowledge of culture, history, and religion/philosophy but also to recognize the unique variance within each family and to be open to the varied intersecting identities that will influence and provide richness to their sessions.