scholarly journals Adenoviral Infection in Suckling Arabian Foals

1970 ◽  
Vol 7 (6) ◽  
pp. 547-565 ◽  
Author(s):  
A. E. McChesney ◽  
J. J. England ◽  
J. K. Adcock ◽  
L. L. Stackhouse ◽  
T. L. Chow
Keyword(s):  
Salivary Glands ◽  
Inclusion Bodies ◽  
Clinical Signs ◽  
Respiratory Epithelium ◽  
Adenoviral Infection

A fatal adenoviral infection was recently recognized in suckling Arabian foals from Colorado, Kansas, Nebraska, and Wyoming. Affected foals had clinical signs of pneumonia accompanied by fever, absolute lymphopenia, and neutropenia. Characteristic lesions with typical adenoviral inclusions occurred in respiratory epithelium of all cases. Other tissues with significant changes and inclusion bodies were conjuctiva, urinary mucosa, pancreas, and salivary glands. Lymphoid follicular atrophy and hepatic degeneration were frequent but were not accompanied by inclusions.

scholarly journals An Outbreak of Adenoviral Infection in Inland Bearded Dragons (Pogona Vitticeps) Coinfected with Dependovirus and Coccidial Protozoa (Isospora Sp.)

2002 ◽  
Vol 14 (4) ◽  
pp. 332-334 ◽  
Author(s):  
Dae Young Kim ◽  
Mark A. Mitchell ◽  
Rudy W. Bauer ◽  
Rob Poston ◽  
Doo-Youn Cho
Keyword(s):  
Inclusion Bodies ◽  
Critical Role ◽  
Clinical Signs ◽  
Head Tilt ◽  
High Morbidity ◽  
Intranuclear Inclusion ◽  
Adenoviral Infection ◽  
Transmission Electron ◽  
Short Period ◽  
20 Nm

Thirty of 200 (15%) hatchling inland bearded dragons were found dead after a short period (48 hours) of weakness and lethargy. The most common clinical signs were head tilt and circling. Six bearded dragons with neurological signs were euthanized, and postmortem examination revealed no gross abnormalities. Microscopically, severe, randomly distributed hepatocellular necrosis with large basophilic intranuclear inclusion bodies in numerous hepatocytes was noted. Small-intestinal enterocytes contained intracytoplasmic coccidial protozoa ( Isospora sp.) and occasional enterocytes had basophilic intranuclear inclusion bodies. Transmission electron microscopy revealed both 80- and 20-nm-diameter viral particles, which were consistent with adenoviruses and dependoviruses, respectively. Adenoviral outbreaks in groups of animals are uncommon. An adverse synergistic effect of the coccidiosis with the adenoviral infection may have played a critical role in the high morbidity and mortality in this case.

scholarly journals ISOLATION OF MUMPS VIRUS FROM HUMAN BEINGS WITH INDUCED APPARENT OR INAPPARENT INFECTIONS

1948 ◽  
Vol 88 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Gertrude Henle ◽  
Werner Henle ◽  
Katherine K. Wendell ◽  
Philip Rosenberg
Keyword(s):  
Salivary Glands ◽  
Clinical Signs ◽  
Mumps Virus ◽  
Chick Embryos ◽  
Human Beings ◽  
Serologic Response

Exposure of fifteen children to mumps virus of fifth amniotic passage in chick embryos led to involvement of the salivary glands in six, orchitis in the absence of other manifestations of mumps in one, and to no signs of illness in eight. Attempts to isolate virus from the saliva of these individuals gave the following results: 1. All patients with involvement of the salivary glands excreted virus beginning on the 11th to 15th day after exposure, 2 to 6 days prior to onset of clinical signs of disease and extending up to the 4th day of illness. 2. The patient with primary orchitis without any recognized involvement of the salivary glands excreted virus for 2 days, beginning on the 15th day after exposure and 10 days prior to his illness. 3. Six of the eight children classified as having inapparent infections because of their serologic response in the absence of clinical signs of illness, began to excrete virus on the 15th to 16th day after exposure for from 1 to 9 or more days. The epidemiologic significance of these data is discussed.

Inhaled Feed Particles in Experimental Pigs with and without Vitamin A Deficiency

1975 ◽  
Vol 12 (5-6) ◽  
pp. 415-427
Author(s):  
K. W. F. Jericho
Keyword(s):  
Vitamin A ◽  
Salivary Glands ◽  
Giant Cell ◽  
Respiratory Disease ◽  
Alveolar Macrophages ◽  
Vitamin A Deficiency ◽  
Respiratory Epithelium ◽  
Dust Exposure ◽  
Distinguishing Features ◽  
Experimental Pigs

An attempt was made to experimentally reproduce an unusual respiratory disease of pigs fed a dusty mixture of finely ground peas, wheat, and barley. Groups of vitamin-A-deficient piglets from this herd were either given dry feed and daily exposure to dust from the feed or were given wet feed. Vitamin-A-fortified pigs of another stock were also given the dry feed and dust exposure. The upper and lower respiratory tracts, renal pelves, and interlobular ducts of salivary glands were studied histologically. The distinguishing features of lungs were starch particles from feed (up to 31.2 μm in diameter) in all lungs (but more in lungs of pigs given dry feed), free alveolar macrophages, giant cell formations, and mild degenerative processes of respiratory epithelium. The epithelium of most renal pelves was marked by mucinous degeneration.

scholarly journals Psittacid herpesvirus 3 infection in rose-ringed parakeets in southern Brazil

2020 ◽  
Vol 32 (3) ◽  
pp. 409-412
Author(s):  
Laurete Murer ◽  
Marília B. Ribeiro ◽  
Glaucia D. Kommers ◽  
Mauro P. Soares ◽  
Juliana F. Cargnelutti ◽  
...  
Keyword(s):  
Inclusion Bodies ◽  
Gene Sequence ◽  
Clinical Signs ◽  
Southern Brazil ◽  
Polymerase Gene ◽  
Intranuclear Inclusion ◽  
Breeding Colony ◽  
Psittacula Krameri ◽  
Viral Particles ◽  
Total Dna

We diagnosed disease caused by psittacid herpesvirus 3 (PsHV-3), a novel psittacid pathogen, in rose-ringed parakeets ( Psittacula krameri) housed in an exotic psittacine breeding colony in southern Brazil. The disease affected several adult birds. Clinical signs included apathy, tachypnea, and wheezing. Four birds were autopsied, and sections of lungs and liver were examined histologically and by electron microscopy (EM), revealing pulmonary congestion, bronchopneumonia, or multifocal necrosis of tertiary bronchi, with syncytial cells and eosinophilic intranuclear inclusion bodies. Viral particles morphologically compatible with herpesviruses were observed by EM in lung sections. PCR with pan-herpesvirus primers performed on total DNA extracted from paraffinized tissue resulted in a 278-bp product. Sequencing of the amplicon revealed 93% nucleotide identity with a PsHV-3 sequence available in GenBank. Phylogenetic analysis grouped the obtained sequence with the only PsHV-3 DNA polymerase gene sequence available (GenBank accession JX028240) and separated the sequence from psittacid herpesviruses 1 and 2. The clinical, pathologic, and molecular findings support the association of PsHV-3 with pneumonia found in these rose-ringed parakeets in southern Brazil.

scholarly journals Salivary gland enlargement and sialorrhoea in dogs with spirocercosis: A retrospective and prospective study of 298 cases

2012 ◽  
Vol 83 (1) ◽  
Author(s):  
Liesel L. Van der Merwe ◽  
Jevan Christie ◽  
Sarah J. Clift ◽  
Eran Dvir
Keyword(s):  
Salivary Gland ◽  
Prospective Study ◽  
Salivary Glands ◽  
Clinical Signs ◽  
Neoplastic Transformation ◽  
Whitney Test ◽  
Mann Whitney Test ◽  
Salivary Gland Enlargement ◽  
Canine Spirocercosis ◽  
Gland Enlargement

This longitudinal cross-sectional clinical study investigated the incidence of sialorrhoea in dogs with spirocercosis and determined whether breed, body weight and the extent of the oesophageal involvement was associated with this presentation. A retrospective analysis was performed on the medical records of 233 dogs and information pertaining to 65 dogs was collected as part of a prospective study. All the animals were client-owned. Patients from the retrospective study underwent thoracic radiography or oesophageal endoscopy to diagnose and characterise the infection and were placed on therapy with a macrocyclic lactone, whereas the patients in the prospective study had both radiography and endoscopy routinely performed and biopsies of the oesophageal nodules collected where possible. Tru-cut biopsies of affected salivary glands were taken in 10 of 13 patients demonstrating clinical signs of sialorrhoea and salivary gland enlargement. The entire salivary gland was sectioned in an additional three dogs with spirocercosis and no sialorrhoea that were presented for post mortem examination. Sialorrhoea was present in 33/298 cases (11%). Fox terrier breeds were over-represented in the patients with sialorrhoea, comprising 36% of cases, whereas they only comprised 1.5% of the patients without sialorrhoea (p < 0.001, chi squared test) and 5% of the combined group. Dogs weighing 12 kg or less were significantly over-represented in the sialorrhoea group, 69% versus 19.5% (p < 0.001, chi square test). Age was not significantly different between the two groups (p < 0.08, Mann-Whitney test). The number of oesophageal nodules per case was significantly higher in the non-sialorrhoea cases (p = 0.048, Mann-Whitney test). The prevalence of distal oesophageal and lower oesophageal sphincter involvement, and neoplastic transformation of the nodules were not statistically different between the two groups. None of the fox terriers in either group showed neoplastic transformation of the parasitic nodules even though they were over-represented as a breed. Mandibular salivary glands were affected in 86% of cases showing sialorrhoea. Histopathology revealed acinar hyperplasia in all cases with concurrent necrosis detected in only two cases.Sialorrhoea and salivary gland enlargement has an incidence of 11% (33/298 cases) in canine spirocercosis. Small breeds (≤ 12 kg) and particularly fox terrier breeds are over-represented in the group demonstrating sialorrhoea and this appeared to be the only risk factor.The conclusion was that sialorrhoea secondary to canine spirocercosis occurs frequently and its presence should prompt further investigation for oesophageal and gastro-intestinal disease. Severely affected patients can be managed with phenobarbitone to control the dysphagia in addition to the routine macrocyclic lactones treatment.

scholarly journals THE PROBLEM OF THE SIGNIFICANCE OF THE INCLUSION BODIES FOUND IN THE SALIVARY GLANDS OF INFANTS, AND THE OCCURRENCE OF INCLUSION BODIES IN THE SUBMAXILLARY GLANDS OF HAMSTERS, WHITE MICE, AND WILD RATS (PEIPING)

1934 ◽  
Vol 60 (6) ◽  
pp. 773-791 ◽  
Author(s):  
Ann G. Kuttner ◽  
Shao-Hsun Wang
Keyword(s):  
Salivary Glands ◽  
Guinea Pigs ◽  
Inclusion Bodies ◽  
Submaxillary Gland ◽  
Infectious Agent ◽  
Intranuclear Inclusion ◽  
Submaxillary Glands ◽  
Normal Individuals ◽  
Wild Rats ◽  
Species Being

1. Acidophilic intranuclear inclusion bodies occur in the salivary glands of Chinese infants dying from miscellaneous causes. The lesion is similar to that previously described in infants in Europe and America. 2. Attempts to prove that this lesion is due to an infectious agent by its production in animals have been unsuccessful. 3. Acidophilic intranuclear inclusion bodies have been found in the submaxillary glands of hamsters, white mice, and wild rats. 4. Evidence is presented to show that the lesion in hamsters, white mice, and wild rats is due to a virus, which is specific for each species, being transmissible to normal individuals of this breed, and which is very similar to the submaxillary gland virus of guinea pigs.

scholarly journals ORAL MANIFESTATIONS OF COVID-19: EARLY DIAGNOSTIC AID?

2020 ◽  
pp. 1-3
Author(s):  
Pooja Katira ◽  
Deep Shah ◽  
Falguni Maniyar
Keyword(s):  
Salivary Glands ◽  
Oral Mucosa ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Healthcare Services ◽  
Oral Lesions ◽  
Oral Manifestations ◽  
Global Pandemic ◽  
Clinical Signs And Symptoms ◽  
Taste And Smell

The outbreak of coronavirus disease which has rapidly escalated into a global pandemic continues to have disastrous health, economic and social effects on the human population. It has markedly affected the delivery of healthcare services all over the world. Early diagnosis of the disease is imperative to contain the spread of the viral infection. The main clinical signs and symptoms produced by SARS-CoV2 have been well described in the literature. However, there is emerging evidence on the oral lesions that may indicate the presence of COVID-19 infection. Since the virus has affinity for angiotensin converting enzyme (ACE2) receptors present in the respiratory tract, oral mucosa, tongue and salivary glands, the oral cavity serves as a major habitat for invasion of the virus. Thus, COVID-19 infection can affect the functioning of salivary glands, integrity of oral mucosa and can also cause alterations in sense of taste and smell. Good oral hygiene can decrease the incidence and severity of the main complications of COVID-19. The present review analyses the available evidence in relation to oral manifestations which are expressed in the course of the coronavirus disease and how it can aid in diagnosing the disease further.

scholarly journals Studi Kasus: Babesiosis (Piroplasmosis) disertai Infestasi Caplak yang Berat pada Anjing Gembala Jerman

2020 ◽  
Vol 1 (2) ◽  
pp. 30-35
Author(s):  
Amar Wira ◽  
I Wayan Batan ◽  
Sri Kayati Widyastuti ◽  
Hendro Sukoco
Keyword(s):  
Inclusion Bodies ◽  
Clinical Signs ◽  
Microcytic Anemia ◽  
The Body ◽  
Parasitic Disease ◽  
Ringer Lactate ◽  
German Shepherd ◽  
Capillary Refill ◽  
Protozoan Infection ◽  
Tick Vectors

Babesiosis is a parasitic disease in red blood cells due to protozoan infection of the genus Babesia which is transmitted through tick vectors. A 5-years-old male German shepherd had decreased appetite, weakness, and infestation of ticks throughout his body. Clinical examination showed Capillary Refill Time (CRT) <2 seconds, pale mouth mucosa, erythema throughout the body, philtrum was dry and slow skin turgor.  The results of a complete blood examination of the dog had hyperchromic microcytic anemia and lymphocytopenia, while the results of blood smear showed the existence of intraerythrocyte inclusion bodies. The dog was diagnosed with Babesiosis and treated with Ringer Lactate fluid therapy, administration of Clindamycin (25mg/kg BW; PO), Oxytetracycline (15mg/kg BW; PO), Anti-inflammatory Dexamethasone (0.5-1mg/kg BW; PO) and Hematodine (1ml/5kg BB; IV) given for seven days.  After treatment, the dog has increased appetite and after 14 days shows improvement in clinical signs.

scholarly journals The role of ozonized oil and a combination of tobramycin/dexamethasone eye drops in the treatment of viral conjunctivitis: a randomized clinical trial

2020 ◽  
Vol 40 (12) ◽  
pp. 3209-3215
Author(s):  
C. Cagini ◽  
M. Mariniello ◽  
M. Messina ◽  
A. Muzi ◽  
C. Balducci ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Pcr Analysis ◽  
Control Group ◽  
Study Group ◽  
Eye Drops ◽  
Adenoviral Infection ◽  
Significant Difference ◽  
Corneal Infiltrates ◽  
Punctate Keratitis

Abstract Purpose To determine whether topical tobramycin 0.3%/dexamethasone 0.1% plus ozonized oil eye drops reduces clinical signs and infectious viral titers of presumed viral conjunctivitis more than tobramycin/dexamethasone eye drops alone. Methods Prospective, single-blind, randomized, parallel-groups trial. Eighty patients with a clinical diagnosis of presumed viral conjunctivitis were randomizedly divided into two treatment groups: a study group and a control group, 40 for each group. Patients in the study group received topical tobramycin 0.3%/dexamethasone 0.1% eye drops, plus ozonized oil eye drops, both four times daily; patients in the control group received only topical tobramycin 0.3%/dexamethasone eye drops four times daily. The treatment was for seven days in both groups. Swabs were taken from the conjunctival fornix for adenovirus PCR analysis on the day of recruitment and at seven days follow-up. Clinical signs were also recorded on the day of recruitment and at follow-up examination: the main outcomes were conjunctival injection and conjunctival chemosis, graded on a 4-point clinical scale, presence or absence of superficial punctate keratitis and subepithelial corneal infiltrates. Results No statistically significant difference was reached in adenoviral infection negativization between the two groups, although the study group showed a higher number of PCR negative results at seven days follow-up. PCR real time detected adenoviral infection in 17 of 24 patients on the day of recruitment and it was positive in 4 patients on the seventh day (viral positivity reduction of 76%). In the control group PCR was positive for adenovirus in 18 of 24 patients on the day of recruitment and in 7 patients at seven days follow-up (reduction of 61%). There was statistically significant difference on conjunctival clinical signs between the study and control groups. Significant difference was also found on superficial punctate keratitis resolution between the study and the control group. In the former superficial punctate keratitis was detected in 14 eyes on the first day and in 5 eyes after seven days while in the latter superficial punctate keratitis was found in 124 eyes on the first day and in 6 eyes on the seventh day. No difference was found in subepithelial corneal infiltrates appearance between the two groups. Conclusions The use of ozonized-oil containing eye drops in combination with topical tobramycin 0.3%/dexamethasone 0.1% eye drops four times daily seems to reduce the signs of conjunctivitis, and the duration of viral infection, although it does not affect the subepithelial corneal infiltrates appearance.

Immunological anomalies and thrombocytopenia in 117 dogs and cats diagnosed with Chronic Fatigue Syndrome (cfs)

2003 ◽  
Vol 51 (1) ◽  
pp. 61-72 ◽  
Author(s):  
W. Tarello
Keyword(s):  
Inclusion Bodies ◽  
Central Italy ◽  
Clinical Signs ◽  
Chronic Fatigue ◽  
Granulocytic Ehrlichiosis ◽  
Protein Levels ◽  
Fatigue Syndrome ◽  
Imidocarb Dipropionate ◽  
Canine Population ◽  
Associated Symptoms

Medical records of thirty-five consecutive cases of canine granulocytic ehrlichiosis (CGE) diagnosed cytologically in Central Italy in 1995-2000 were analysed retrospectively. Tick exposure was reported in 16 dogs (45.7%) and concurrent babesiosis in 19 dogs (54.3%). Ehrlichia-like inclusion bodies were found in neutrophils in a percentage varying from 0.5% to 11%. Frequently recorded clinical signs included anorexia (71.4%), lethargy (45.7%), conjunctivitis (31.4%), fever (25.7%), lameness (20%) and ataxia (20%). Among the 16 representative dogs in which protein electrophoresis was performed, 10 (62.5%) showed high globulin levels and 6 (37.5%) had concurrent high total protein levels. During treatment with doxycycline, all associated symptoms, including those unusually described, such as pyoderma intertrigo, erythema, apparent blindness and oral papillomatosis, progressively disappeared in 31 (89%) out of 35 dogs. The efficacy of treatment was marked in dogs simultaneously treated twice with imidocarb dipropionate: among the 14 dogs in which a fast recovery was noted, 11 (80%) were concurrently affected by babesiosis and consequently treated with the specific medicament leading to excellent outcomes. The main conclusion is that CGE is present among dogs from Central Italy and should be included in the differential diagnosis of possible zoonotic agents affecting the canine population.

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