In this Introduction, I frame the book’s argument around two issues: the project of a Political Commission, which Jean-Claude Juncker and Pierre Moscovici embodied, and political work in international organizations more generally. Political work, I argue, is the practice of trying to carve out a space for political agency in an environment that is heavily constrained by bureaucratic rules, international norms, and intergovernmental power structures. I contrast political work with other logics of action: technocratic expertise, the application of legal norms and institutional rules, market pressures, and diplomacy. Then I explain the effects and social dynamics of international political work.