This chapter focuses on a struggling high school in a rural Kentucky community that made a dramatic turnaround within 2 years after establishing response to intervention structures to support both teachers and students. The principal, special education director, other administrators, district personnel, school improvement specialists, teacher leaders, and school faculty implemented changes that were responsible for the turnaround and for sustaining this success. High expectations, a positive school culture, professional development, guided planning, student assessment, data analysis, research-based intervention programs, and a systems change approach are some of the contributions that led to widespread improvements at the school level and in individual student gains.