Chapter 1 reviews the history of psychiatric treatment of people with mental illness in the United States and Western Europe, highlighting past perspectives in care, such as ancient trephination and exorcism during the demonology era, humorism in early Greek and Roman thought, a return to demonological perspectives in the Middle Ages, as well as mesmerism and psychoanalysis in the 19th and 20th centuries. The 20th-century biological perspective is described, including the use of insulin shock therapy, electroconvulsive therapy, and lobotomy. Next, the development of more humane treatment approaches is discussed, such as the moral treatment movement of the 1800s. The ex-patient’s movement of the 1970s is reviewed, leading up to the contemporary recovery-oriented and psychosocial rehabilitation models of care. The impact of stigma on the acceptance of serious mental illness is explored throughout this history. Discussion questions, activities, and diagrams are also included.