Allopurinol in the treatment of neoplastic disease complicated by hyperuricemia

SummaryA continuous parameter, stationary Gaussian process is introduced as a first approach to the probabilistic representation of the phenotype inheritance process. With some specific assumptions about the components of the covariance function, it may describe the temporal behaviour of the “cancer-proneness phenotype” (CPF) as a quantitative continuous trait. Upcrossing a fixed level (“threshold”) u and reaching level zero are the extremes of the Gaussian process considered; it is assumed that they might be interpreted as the transformation of CPF into a “neoplastic disease phenotype” or as the non-proneness to cancer, respectively.

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Structural description of sea turtle fibropapilloma

Brazilian Journal of Veterinary Pathology ◽

10.24070/bjvp.1983-0246.v13i3p585-591 ◽

2020 ◽

Vol 13 (3) ◽

pp. 585-591

Author(s):

Luana Melo ◽

Isabel Velasco ◽

Julia Aquino ◽

Rosangela Rodrigues ◽

Edris Lopes ◽

...

Keyword(s):

Green Turtle ◽

Chelonia Mydas ◽

Sea Turtle ◽

Tumor Formation ◽

Neoplastic Disease ◽

Structural Description ◽

Chemical Carcinogens ◽

Epidermal Proliferation ◽

Turtle Population ◽

Bulky Mass

Fibropapillomatosis is a neoplastic disease that affects sea turtles. It is characterized by multiple papillomas, fibropapillomas and cutaneous and/or visceral fibromas. Although its etiology has not been fully elucidated, it is known that there is a strong involvement of an alpha - herpesvirus, but the influence of other factors such as parasites, genetics, chemical carcinogens, contaminants, immunosuppression and ultraviolet radiation may be important in the disease, being pointed out as one of the main causes of a reduction in the green turtle population. Thus, the objective of this article was to describe the morphology of cutaneous fibropapillomas found in specimens of the green turtle (Chelonia mydas), using light and scanning electron microscopy in order to contribute to the mechanism of tumor formation. Microscopically, it presented hyperplastic stromal proliferation and epidermal proliferation with hyperkeratosis. The bulky mass was coated with keratin, with some keratinocyte invaginations, that allowed the keratin to infiltrate from the epidermis into the dermis, forming large keratinized circular spirals. Another fact that we observed was the influence of the inflammation of the tumors caused by ectoparasites.

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Understanding Molecular Process and Chemotherapeutics for the Management of Breast Cancer.

Current Chemical Biology ◽

10.2174/2212796814999200728185759 ◽

2020 ◽

Vol 14 ◽

Author(s):

Abhishek Kumar ◽

Neeraj Masand ◽

Vaishali M. Patil

Keyword(s):

Breast Cancer ◽

Molecular Mechanisms ◽

Molecular Targets ◽

Molecular Classification ◽

Neoplastic Disease ◽

Molecular Process ◽

The Past ◽

Anti Cancer ◽

Molecular Etiology ◽

Near Future

Abstract: Breast cancer is the most common and highly heterogeneous neoplastic disease comprised of several subtypes with distinct molecular etiology and clinical behaviours. The mortality observed over the past few decades and the failure in eradicating the disease is due to the lack of specific etiology, molecular mechanisms involved in initiation and progression of breast cancer. Understanding of the molecular classes of breast cancer may also lead to new biological insights and eventually to better therapies. The promising therapeutic targets and novel anti-cancer approaches emerging from these molecular targets that could be applied clinically in the near future are being highlighted. In addition, this review discusses some of the details of current molecular classification and available chemotherapeutics

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FEVER IN MALIGNANT NEOPLASTIC DISEASE: A CONTROLLED STUDY OF TETRACYCLINE THERAPY

Annals of Internal Medicine ◽

10.7326/0003-4819-53-4-754 ◽

1960 ◽

Vol 53 (4) ◽

pp. 754 ◽

Cited By ~ 7

Keyword(s):

Controlled Study ◽

Neoplastic Disease

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Osteonecrosis of the jaw: a rare but possible side effect in thyroid cancer patients treated with tyrosine-kinase inhibitors and bisphosphonates

Journal of Endocrinological Investigation ◽

10.1007/s40618-021-01634-0 ◽

2021 ◽

Author(s):

L. Lorusso ◽

L. Pieruzzi ◽

M. Gabriele ◽

M. Nisi ◽

D. Viola ◽

...

Keyword(s):

Thyroid Cancer ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Side Effect ◽

Kinase Inhibitors ◽

Osteonecrosis Of The Jaw ◽

Antiangiogenic Agents ◽

Neoplastic Disease ◽

External Radiation Therapy ◽

Serious Disease

AbstractOsteonecrosis of the jaw (ONJ) is a rare but very serious disease that can affect both jaws. It is defined as exposed bone in the maxillofacial region that does not heal within 8 weeks after a health care provider identification. ONJ can occur spontaneously or can be due to drugs like bisphosphonates (BPS) and anti-RANK agents, in patients with no history of external radiation therapy in the craniofacial region. Although in phase 3 trials of tyrosine kinase inhibitors (TKIs) used in thyroid cancer (TC) the ONJ was not reported among the most common side effects, several papers reported the association between ONJ and TKIs, both when they are used alone and in combination with a bisphosphonate. The appearance of an ONJ in a patient with metastatic radio-iodine refractory differentiated TC, treated with zoledronic acid and sorafenib, has put us in front of an important clinical challenge: when a ONJ occurred during TKIs treatment, it really worsens the patients’ quality of life. We should consider that in the case of ONJ a TKI discontinuation becomes necessary, and this could lead to a progression of neoplastic disease. The most important aim of this review is to aware the endocrinologists/oncologists dealing with TC to pay attention to this possible side effect of BPS and TKIs, especially when they are used in association. To significantly reduced the risk of ONJ, both preventive measures before initiating not only antiresorptive therapy but also antiangiogenic agents, and regular dental examinations during the treatment should always be proposed.

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Toxoplasma encephalitis presenting as neoplastic disease: A single institution case series

Interdisciplinary Neurosurgery ◽

10.1016/j.inat.2021.101174 ◽

2021 ◽

Vol 25 ◽

pp. 101174

Author(s):

Jennifer L. Perez ◽

Zachary C. Gersey ◽

Daniel F. Marker ◽

Georgios A. Zenonos ◽

Pascal O. Zinn

Keyword(s):

Case Series ◽

Neoplastic Disease ◽

Single Institution ◽

Toxoplasma Encephalitis

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The Role of Visceral Transplantation for Neoplastic Disease

Digestive Disease Interventions ◽

10.1055/s-0040-1715810 ◽

2020 ◽

Vol 04 (03) ◽

pp. 273-281

Author(s):

Masato Fujiki ◽

Amit Nair ◽

Giuseppe D'amico ◽

Mohammed Osman

Keyword(s):

Patient Survival ◽

Ex Vivo ◽

Tumor Resection ◽

Case Series ◽

National Database ◽

Neuroendocrine Neoplasms ◽

Neoplastic Disease ◽

Desmoid Tumors ◽

Post Transplant ◽

Recipient Tissue

AbstractVisceral transplantation has been utilized as the most radical surgical treatment for neoplasms not amenable to conventional resection. The main indications for this procedure include mesenteric desmoid tumors threatening the root of mesentery and metastatic neuroendocrine neoplasms. Published case-series of visceral transplantation for such indications are reviewed in this article. Patients with desmoid tumors associated with familial adenomatous polyposis are transplanted with intestinal or multivisceral allografts. With surgical modification of technique, the native spleen is preserved while duodenopancreatic complex is removed to obviate the risk of malignant transformation of duodenal polyposis after transplantation. Preservation of spleen decreased incidence of post-transplant lymphoproliferative disorder, conferring therapeutic advantage. Patient survival is comparable to that of other indications, and desmoid tumor recurrence has been observed in the recipient tissue but not in the donor allograft. For visceral transplantation of metastatic neuroendocrine neoplasms, the majority of these patients have diffuse liver involvement, thus requiring full multivisceral transplantation. Post-transplant patient survival is acceptable with limited data available on recurrence. Autotransplantation following ex vivo tumor resection using visceral allografts has been also performed in a limited, select cohort of patients with various pathologies. Adenocarcinomas are associated with a prohibitive recurrence rate following the procedure, and its use for this indication is therefore not recommended. A national database of visceral transplantation undertaken for neoplastic disease should be developed to better understand predictors of outcomes and to help produce and standardize selection criteria.

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