Serologic Testing for Hepatitis B

JAMA ◽  
2021 ◽  
Author(s):  
Maroun M. Sfeir ◽  
Mary Snayd
2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S115-S115
Author(s):  
E A Dent ◽  
J Guarner

Abstract Introduction/Objective Although serology concepts are a frequent exam topic for Pathology trainees, serology education remains challenging, in part, because serologic test performance occurs in different laboratories (immunology, microbiology, or chemistry.) Serology education topics may be eclipsed by larger concerns of the laboratory where serology resides. To evaluate the utility and advantages of online modules as adjuncts to other education modalities used during a standalone serology rotation, we developed a one-week curriculum in which residents were given four case-based vignettes to discuss with faculty, eight online case-based simulation modules, and bench time in the laboratory performing serological tests (RPR, VDRL, hepatitis, and HIV). Methods The online modules are housed within an e-learning portal. Residents were asked to print certificate of completion for eight assigned modules. Residents were offered an anonymous survey of the rotation between one week and up to 2 months after completing the rotation. Results Twenty-three first-year residents (spanning a 3-year period) completed the online modules, and 10 (43.5%) completed the survey. The average percentage of correct answers ranged from 73% for the HIV module to 88% for the hepatitis B module. The number of residents with scores below 80% was highest for EBV and Cryptococcus modules (8 and 9 scoring <80% respectively) and lowest for hepatitis B and toxoplasmosis modules (2 and 3 respectively). On the survey, residents stated they had repeated the online modules between 1 and 4 times, averaging between 1 and 2 attempts. Although there was no specific module rated as most enjoyable, the toxoplasmosis and EBV modules were picked by 3 out of 10 residents as his or her favorite. There was no consensus on which module was subjectively easiest or most difficult, nor which was least enjoyed. The majority of the residents (7/10) found the modules helpful and all ten residents stated that they “learned more” after completion of the modules because they reinforced (6/10) concepts important to serologic testing. Conclusion The online, case-based simulation modules are effective additions to a serology curriculum that includes case-based discussions and time in the laboratory performing tests. The online modules are effective because they provide additional structure and reinforce learning within the serology curriculum.


2014 ◽  
Vol 17 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Kelvin Nguyen ◽  
Thai Van Nguyen ◽  
Duke Shen ◽  
Victor Xia ◽  
Diep Tran ◽  
...  

2019 ◽  
Vol 8 (12) ◽  
pp. 2085 ◽  
Author(s):  
Yoon Suk Jung ◽  
Nam Hee Kim ◽  
Jung Ho Park ◽  
Dong Il Park ◽  
Chong Il Sohn

Background: Data about the association between hepatitis virus infection and colorectal neoplasia (CRN) are extremely limited. We examined the association between hepatitis B virus (HBV) and hepatitis C virus (HCV) infection with the risk of CRN. Methods: A cross-sectional study was performed on asymptomatic examinees who underwent a colonoscopy and serologic testing for hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCV Ab) between 2004 and 2015. Results: Of 155,674 participants who underwent serologic testing for HBsAg, 5476 (3.5%) were positive for HBsAg. The mean age of the study participants was 41.1 ± 9.1 years. The prevalence of CRN was higher in the HBsAg (+) than in HBsAg (-) participants (16.9% vs. 15.6%, p = 0.009). Even after adjusting for confounders, HBsAg positivity was correlated with an increased risk of CRN (odds ratio (OR), 1.10; 95% confidence interval (CI), 1.01–1.19; p = 0.025). Of 155,180 participants who underwent serologic testing for HCV Ab, only 240 (0.15%) were positive for HCV Ab. The prevalence of CRN was higher in HCV Ab (+) than in HCV Ab (-) participants (22.9% vs. 15.6%, p = 0.002). However, the association disappeared after adjusting for confounders (OR, 1.04; 95% CI, 0.72–1.50; p = 0.839). Conclusions: HBV infection was independently correlated with an increased risk of CRN. Our results indicate the possibility that HBV infection may contribute to colorectal carcinogenesis. Screening colonoscopy may have to be recommended more thoroughly for HBV-infected patients.


2015 ◽  
Vol 64 (39) ◽  
pp. 1118-1120 ◽  
Author(s):  
Sarah Schillie ◽  
Trudy V. Murphy ◽  
Nancy Fenlon ◽  
Stephen Ko ◽  
John W. Ward

2018 ◽  
Vol 66 (1) ◽  
pp. 8-14
Author(s):  
Daniela Nunes NOGUEIRA ◽  
Juliana Cama RAMACCIATO ◽  
Rogério Heládio Lopes MOTTA ◽  
Rui Barbosa de BRITO JÚNIOR ◽  
Almenara de Souza FONSECA-SILVA ◽  
...  

ABSTRACT Objective: To describe the development of a dentistry school strategy in order to reduce the occupational risk related to hepatitis B. Methods: The academic registration documents of 242 students entering the institution between the years 2006 and 2013, were evaluated, among which were of copies of the updated vaccination cards and anti-HBs serologic testing. Demographic variables and others related to the vaccination status of hepatitis B and seroconversion were considered. Results: One hundred percent of the students were found to be vaccinated, and 87.2% had vaccination records of three doses. The results of anti-HBs tests proved seroconversion in 91.3% of the students. From 2011, the dental school was able to institutionalize the follow-up behavior of the students who had anti-HBs non-reactive. Of the twenty individuals whose serology was negative, nine students (45% of the total and all of the 2011-2013 class) were followed-up and repeated the basic vaccination and anti-HBs test; eight seroconverted and one was considered a non-responder, increasing the percentage of immune students to 95%. Eleven (55%) had other unregistered behavior or the documents analyzed showed no data on them. Conclusion: The procedure of following-up the registration in vaccination records required by the Biosafety Committee of the institution was shown to be effective in reducing the occupational risk of hepatitis B among the students.


Vaccine ◽  
2017 ◽  
Vol 35 (33) ◽  
pp. 4229-4235 ◽  
Author(s):  
Fuzhen Wang ◽  
Guomin Zhang ◽  
Hui Zheng ◽  
Ning Miao ◽  
Liping Shen ◽  
...  

2014 ◽  
Vol 56 (4) ◽  
pp. 307-311 ◽  
Author(s):  
Eduardo Pernambuco de Souza ◽  
Marcelo de Souza Teixeira

The aim of this cross-sectional study was to determine the hepatitis B vaccination coverage among medical students at a public university in Rio de Janeiro, Brazil, and their compliance with the postvaccination serologic testing recommendations. Of the total of 858 students, 675 (78.7%) participated in the study. Among the participants, 48.9% (95% CI: 45.1% to 52.7%) were vaccinated against hepatitis B (received ≥ 3 doses of the vaccine), 31.6% were not (received 0, 1 or 2 doses), and 19.6% did not know their vaccination status. Hepatitis B vaccination coverage increased from 26.0% among first-year students to 70.6% among sixth-year students while the prevalence of unknown vaccination status decreased from 39.7% among first-year students to 2.4% among sixth-year students. The frequency of unvaccinated students ranged from 23.7% among fifth-year students to 34.4% among first-year students. Only 34.8% of the vaccinated students performed the anti-HBs testing after vaccination. Among these medical students, we found a low adherence to the hepatitis B vaccination and to the postvaccination serologic testing. A comprehensive hepatitis B immunization program should be offered to students at this medical school.


1984 ◽  
Vol 48 (4) ◽  
pp. 208-210
Author(s):  
PG Fotos ◽  
RW Miller ◽  
WL Graham ◽  
DC Bowers

1984 ◽  
Vol 48 (10) ◽  
pp. 563-565
Author(s):  
HJ Kwon ◽  
KM Keenan ◽  
H Colman ◽  
KM Sundeen ◽  
DE Waite

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