Differences in Morbidity and Mortality Rates in Black, White, and Hispanic Very Preterm Infants Among New York City Hospitals

Abstract Colorectal cancer (CRC) incidence rates are rising in younger Americans and mortality rates are increasing among younger white Americans. We used New York State Cancer Registry data to examine New York City CRC incidence and mortality trends among adults ages 20–54 years by race from 1976 to 2015. Annual percent change (APC) was considered statistically significant at P less than .05 using a two-sided test. CRC incidence increased among those ages 20–49 years, yet blacks had the largest APC of 2.2% (1993–2015; 95% confidence interval [CI] = 1.4% to 3.1%) compared with 0.5% in whites (1976–2015; 95% CI = 0.2% to 0.7%). Among those aged 50–54 years, incidence increased among blacks by 0.8% annually (1976–2015; 95% CI = 0.4% to 1.1%), but not among whites. CRC mortality decreased among both age and race groups. These findings emphasize the value of local registry data to understand trends locally, the importance of timely screening, and the need for clinicians to consider CRC among all patients with compatible signs and symptoms.

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New York City AIDS case mortality rates in the era of potnt antiretroviral therapy

Journal of Urban Health ◽

10.1007/bf02390536 ◽

2000 ◽

Vol 77 (2) ◽

pp. 255-257 ◽

Cited By ~ 4

Author(s):

Mary Ann Chiasson

Keyword(s):

New York ◽

New York City ◽

Antiretroviral Therapy ◽

York City ◽

Mortality Rates ◽

Case Mortality

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School-age outcomes of late preterm infants in New York City

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2012.01.007 ◽

2012 ◽

Vol 206 (3) ◽

pp. 222.e1-222.e6 ◽

Cited By ~ 55

Author(s):

Heather S. Lipkind ◽

Meredith E. Slopen ◽

Melissa R. Pfeiffer ◽

Katharine H. McVeigh

Keyword(s):

New York ◽

New York City ◽

Preterm Infants ◽

York City ◽

Late Preterm ◽

School Age ◽

Late Preterm Infants

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228: Surgical Morbidity and Mortality During the COVID-19 Epidemic in New York City

Critical Care Medicine ◽

10.1097/01.ccm.0000726800.38611.51 ◽

2020 ◽

Vol 49 (1) ◽

pp. 99-99

Author(s):

Samantha Levine ◽

Ryan Linzer ◽

Jacqueline Labins ◽

Joseph Kim ◽

Atsumi Kimura ◽

...

Keyword(s):

New York ◽

New York City ◽

York City ◽

Morbidity And Mortality ◽

Surgical Morbidity

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Morbidity and mortality of infective endocarditis in a hospital system in New York City serving a diverse urban population

Journal of Investigative Medicine ◽

10.1136/jim-2015-000040 ◽

2016 ◽

Vol 64 (6) ◽

pp. 1118-1123 ◽

Cited By ~ 9

Author(s):

Hassan Alkhawam ◽

Robert Sogomonian ◽

Feras Zaiem ◽

Neil Vyas ◽

Mohammed El-Hunjul ◽

...

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

New York ◽

New York City ◽

Infective Endocarditis ◽

York City ◽

Heart Valves ◽

Morbidity And Mortality ◽

Unknown Etiology ◽

Control Group

Infective endocarditis (IE) is a severe illness associated with significant morbidity and mortality. The primary purpose of this study was to evaluate morbidity and mortality of IE in a hospital serving the most diverse area in New York City. An analysis of 209 patients admitted to the hospital from 2000 to 2012 who were found to have IE based on modified Duke criteria. Among the 209 patients with IE, 188 (88.8%) had native heart valves and 21 (11.2%) had prosthetic valves. Of the patients with native heart valves, 3.7% had coronary artery bypass graft, 4.3% were active drug users, 6.3% had permanent pacemakers, 12.2% had a history of IE, 25.7% were diabetic, 17% had end-stage renal disease (ESRD), 9% had congestive heart failure, 8% had abnormal heart valves, and 13.8% had an unknown etiology. Mortality rates of the patients with prosthetic heart valves were 27.7% compared to 8.11% in patients with native heart valves (OR 3, p<0.0001). Since we identified diabetes mellitus and ESRD to be significant risk factors in our population, we isolated and compared characteristics of patients with and without IE. IE among patients with diabetes mellitus was 23% compared with 13.8% in the control group (p=0.016). Cases of IE in patients with ESRD were 15.3%, compared with 4% in the control group (p<0.0001). We identified an overall mortality rate of 20.1% in patients with IE, a readmission rate within 30 days of discharge of 21.5%, and an average age of 59 years. Among 209 patients, 107 were males and 102 females. The most common organisms identified were Staphylococcus aureus (43.7%), viridans streptococci (17%) followed by Enterococcus (14.7%). Despite appropriate treatment, high rates of morbidity and mortality remained, with a higher impact in patients greater than 50 years of age. Such discoveries raise the importance of controlling and monitoring risk factors for IE.

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Cancer Mortality among Persons with Human Immunodeficiency Virus Infection in New York City, 2001–2015

Open Forum Infectious Diseases ◽

10.1093/ofid/ofx162.135 ◽

2017 ◽

Vol 4 (suppl_1) ◽

pp. S58-S58

Author(s):

Chitra Ramaswamy ◽

Emily Westheimer ◽

Sarah Braunstein

Keyword(s):

New York ◽

New York City ◽

Cause Of Death ◽

York City ◽

Cancer Mortality ◽

Mortality Rates ◽

Vital Statistics ◽

Cd4 Count ◽

Transmission Risk ◽

The Mean

Abstract Background With the prolonged life-span of persons with HIV (PWH) due to anti-retroviral therapy, their cancer burden has increased. Cancer continues to be a leading cause of death among PWH. Studying cancer mortality can inform and guide the development of cancer screening and prevention strategies for PWH. Methods We analyzed data for all persons > = 13 years who were diagnosed with HIV from 2001 to 2015 and reported to the New York City (NYC) HIV surveillance registry (HSR). Using the HSR and the underlying cause of death obtained from the NYC vital statistics registry and the National Death Index, we examined age-specific and age-standardized mortality rates from cancer and compared time trends of deaths due to HIV-related8 cancer to deaths from non-HIV-related cancers. Results There were 34,190 deaths reported among 154,688 PWH of whom nearly half (n = 16,804; 49.1%) died due to HIV (excluding HIV-related cancers). Among all deaths, HIV was the leading cause, followed by cancer (both HIV and non-HIV-related) (n = 5,271; 15.4%) and cardiovascular disease (n = 3,724, 10.9%). The top three causes of non-HIV-related cancer deaths were lung cancer (n = 1,040; 19.7%), liver cancer (n = 552; 10.5%), and colorectal cancer (n = 315; 5.6%). Although the mortality rate among PWH decreased over time (24.4 to 13.9 per 1,000 person-years from 2001 to 2015), the proportion of deaths attributable to all cancers increased (10.6% in 2001 to 19.9% in 2015, p < .0001). This increase was driven by non-HIV-related cancers (6.1% of all deaths in 2001 to 15.8% in 2015, p < .0001). The mean age increased from 2001 to 2015 among the dead (46 to 56 years) and among the censored (35 to 49 years). After controlling for demographic factors, transmission risk, and last CD4 count, the hazard ratio for cancer deaths was higher among people who inject drugs (HR = 1.5; 95% CI = 1.4–1.7) and those with last CD4 count < 200 (HR = 9.3; 95% CI = 8.3–10.5). Conclusion Although mortality rates are decreasing in PWH, deaths due to non-HIV-related cancers are increasing. The upward trend in the mean age suggests that aging may be contributing to this increase. Routine screening for liver and colon cancers along with smoking cessation may reduce lung, liver and colon cancer deaths. Disclosures All authors: No reported disclosures.

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Population Structure of Klebsiella pneumoniae Causing Bloodstream Infections at a New York City Tertiary Care Hospital: Diversification of Multidrug-Resistant Isolates

Journal of Clinical Microbiology ◽

10.1128/jcm.03455-14 ◽

2015 ◽

Vol 53 (7) ◽

pp. 2060-2067 ◽

Cited By ~ 40

Author(s):

Angela Gomez-Simmonds ◽

Michelle Greenman ◽

Sean B. Sullivan ◽

Joshua P. Tanner ◽

Madeleine G. Sowash ◽

...

Keyword(s):

New York ◽

New York City ◽

Klebsiella Pneumoniae ◽

York City ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Bloodstream Infections ◽

Mortality Rates ◽

Care Hospital ◽

Content Type

Despite the growing importance of carbapenem-resistantKlebsiella pneumoniae(CRKP), the clonal relationships between CRKP and antibiotic-susceptible isolates remain unclear. We compared the genetic diversity and clinical features of CRKP, third-generation and/or fourth-generation cephalosporin-resistant (Ceph-R)K. pneumoniae, and susceptibleK. pneumoniaeisolates causing bloodstream infections at a tertiary care hospital in New York City between January 2012 and July 2013. Drug susceptibilities were determined with the Vitek 2 system. Isolates underwent multilocus sequence typing and PCR sequencing of thewziandblaKPCgenes. Clinical and microbiological data were extracted from patient records and correlated with molecular data. Among 223 patients, we identified 272 isolates. Of these, 194 were susceptible, 30 Ceph-R, and 48 CRKP, belonging to 144 sequence types (STs). Susceptible (127 STs) and Ceph-R (20 STs) isolates were highly diverse. ST258 dominated CRKP strains (12 STs, with 63% ST258). There was minimal overlap in STs between resistance groups. TheblaKPC-3gene (30%) was restricted to ST258/wzi154, whereasblaKPC-2(70%) was observed for severalwziallele types. CRKP infections occurred more frequently among solid organ transplant (31%) and dialysis (17%) patients. Mortality rates were high overall (28%) and highest among CRKP-infected patients (59%). In multivariable analyses, advanced age, comorbidities, and disease severity were significant predictors of 30-day mortality rates, whereas theK. pneumoniaesusceptibility phenotype was not. Among CRKP infections, we observed a borderline significant association of increased mortality rates with ST258 and thewzi154 allele. Although the clonal spread of ST258 continues to contribute substantially to the dissemination of CRKP, non-ST258 strains appear to be evolving. Further investigations into the mechanisms promoting CRKP diversification and the effects of clonal backgrounds on outcomes are warranted.

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