Management of low-grade squamous intra-epithelial lesions of the uterine cervix: repeat cytology versus immediate referral to colposcopy

2012 ◽  
Author(s):  
Maria Kyrgiou ◽  
Sofia Melina Stasinou ◽  
Marc Arbyn ◽  
George Valasoulis ◽  
Sadaf Ghaem-Maghami ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Low Grade ◽  
Epithelial Lesions

AgNOR, p16 and human papillomavirus in low-grade squamous intra-epithelial lesions of the uterine cervix. Preliminary report

2011 ◽  
Vol 87 (4) ◽  
pp. 257-264 ◽  
Author(s):  
JV Hidalgo ◽  
AE Rocher ◽  
JL López ◽  
M Gamboni ◽  
S Vighi ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Uterine Cervix ◽  
Preliminary Report ◽  
Low Grade ◽  
Epithelial Lesions

scholarly journals Present potential of exfoliative cytology in detection of cervix cancer

2013 ◽  
Vol 1 (1) ◽  
pp. 17
Author(s):  
Sushila Jain ◽  
Anuj Paudel ◽  
S K Jain
Keyword(s):  
Epithelial Cell ◽  
Pap Smear ◽  
Screening Program ◽  
Cervical Screening ◽  
National Policy ◽  
Cross Sectional Study ◽  
Pap Smears ◽  
Low Grade ◽  
Cross Sectional ◽  
Epithelial Lesions

  Introduction: Conventional Pap smear is the mainstay for cervical cancer screening in developing countries and women should be motivated for cervical screening program to detect early dysplastic cells. This study was carried out to find out the prevalence of abnormalities in Pap smears, particularly pattern of epithelial cell abnormality in women attending Lumbini Medical College in western Nepal.   Methods: A cross-sectional study was carried out and 1066 Pap smears were studied to look for epithelial cell abnormality according to revised Bethesda system 2001.   Results: Out of 1066 patients who underwent Pap smear examination, 71 (6.6%) revealed epithelial cell abnormality; most were low grade squamous intra-epithelial lesions (LSIL) occupying 4.59% at the age between 23 to 29 years. Squamous cell carcinoma was found in 0.37 % of patients at the age 40 years and above. In our scenario, per vaginal discharge was the major finding of the patients who showed premalignant features.   Conclusions: Women above 40 years are at a risk of premalignant as well as malignant lesions and these women should undergo screening for abnormal cells at the age of 18 or when sexual activity starts and as per recommendations to look for early dysplastic cells. Cervical screening program should be motivated by the national policy makers and also by health professionals.

scholarly journals A Comparative Study between Conventional Pap Smear and Liquid-Based Cytology: A Clinco-Cytological Study of Iraqi Women with Some Health Problems of Cervix

2019 ◽  
pp. 2362-2370
Author(s):  
Huda Hameed K. Alabbody ◽  
Zahraa Adnan G. Al-Ghuraibawi
Keyword(s):  
Cervical Cancer ◽  
Uterine Cervix ◽  
Visual Inspection ◽  
Pap Smear ◽  
Cervical Screening ◽  
Health Problems ◽  
Low Grade ◽  
Sexually Active ◽  
Iraqi Women ◽  
Liquid Based Cytology

A cervical screening by Pap test is necessary in recognizing precancerous and cancerous cases to reduce mortality due to cervical cancer among women. Regular screening and follow up can make it easier to early diagnose and eventually, to treat and control cervical cancer.     This study aimed to detect atypical pathological changes of the vagina and uterine cervix of a sample of Iraqi women by macro- and micro-examination, and to determine the link with the demographic features. Also the study aimed to evaluate the two Pap smear techniques; the conventional and the base liquid methods.      The study included 50 women with genital health problems (18-50 years old) who were referred to the National Cancer Research Center (NCRC), the University of Baghdad, during the period from 1st April to 30st of September 2018. Both visual inspection of the uterine cervix and Papanicolaou smear were performed for all of the participants.      The results showed that most patient women (96%) were married and sexually active, with 51% being married under 20 years of age .Visual inspection of the cervix showed that 30% of the women had translucent, opaque or erosion lesions. Upon cytology examination, 92% of the women showed nonspecific inflammation, 70% revealed reactive squamous metaplasia, 10% had Koilocytotic atypia, and 8% suffered from cervical intraepithelial neoplasia (CIN1) or low grade squamous intraepithelial lesion (LGSIL). Contraception was used by 82% of the patients, while 36% used pills. The causes of the referral to the centre were abnormal vaginal discharge (44%) and post-coital bleeding "and\or" dyspareunia (20% each). Lastly, 74% of the participants did not make this test previously. Liquid-based cytology technique outperformed conventional pap smears because of improved fixation, decreased impurities factors, and standardization of cell transfer.     We conclude that routine screening and Pap smear testing for uterine cervix and vagina might be useful to prevent the occurrence of precancerous lesions in the genital system of sexually active women. We recommend to apply this test before and after treatment and to activate the cellular examination in the basal fluid method

Ras and C-Myc Oncoproteins during Tumor Progression in the Uterine Cervix

1998 ◽  
Vol 84 (5) ◽  
pp. 583-588 ◽  
Author(s):  
Sivakumari Asha Nair ◽  
Madhavan Balaraman Nair ◽  
Puthuveetil Govindan Jayaprakash ◽  
Thayyullathil Nellika Rajalekshmy ◽  
Madhavan Krishnan Nair ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Uterine Cervix ◽  
Mean Value ◽  
Low Grade ◽  
Cervical Tissue ◽  
Ras Gene ◽  
Tissue Samples ◽  
Cervical Epithelium ◽  
Malignant Lesions ◽  
The Many

Aims and background Altered oncogenic activity is a feature associated with many malignant and premalignant conditions. Among the many oncogenes, ras and myc are commonly altered in many tumors. This study aims to evaluate the expression of ras and c-myc oncoproteins in a total of 204 cervical tissue samples, including premalignant and malignant lesions as well as apparently normal cervical tissue. Methods and study design Mouse monoclonal antibodies against the three mammalian ras gene products (c-H-ras, c-K-ras, c-N-ras) and the c-myc protein were used to evaluate oncoprotein expression by immunocytochemistry. Results None of the samples analyzed displayed immunoreactivity for H-ras and K-ras. Normal cervical epithelium showed minimal immunoreactivity for N-ras with about 33% of the samples expressing the protein. More conspicuous expression in normal tissue was displayed by c-myc, with about 90% of the samples expressing the protein (mean value of cells positive = 34%). The immunoreactivity for N-ras increased with increasing histological abnormality from low-grade squamous intraepithelial lesions (SIL) to invasive carcinoma. Increased immunoreactivity for N-ras was evident in the basaloid cells of malignant lesions, with the maximum value of 66% found in poorly differentiated squamous cell carcinoma (PDSCC). The percentage of nuclei positive for c-myc also showed a gradual increase from low-grade SIL onwards, the highest positivity being found in PDSCC, where the mean value was 85%. Statistical analysis revealed a good correlation between the expression of N-ras (r = 0.8922, P = 0.001) and c-myc (r = 0.8856, P =0.001) and various histological stages of tumor progression in the cervical epithelium. Conclusions These results therefore suggest that c-myc and N-ras oncoproteins are important during tumor progression in the uterine cervix.

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