Protective Role of Black-Tea Extract in a TransgenicDrosophilaModel of Parkinson's Disease

2017 ◽  
pp. 317-334 ◽  
Author(s):  
Yasir Hasan Siddique
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Black Tea ◽  
Protective Role ◽  
Black Tea Extract ◽  
Tea Extract

scholarly journals The protective role of black tea extract against indomethacin-induced toxicity in the prostate gland of rats

2020 ◽  
Vol 5 (3) ◽  
pp. 43
Author(s):  
IshwarB Bagoji ◽  
GA Hadimani ◽  
RS Bulagouda ◽  
MK Qureshi ◽  
KusalK Das
Keyword(s):  
Prostate Gland ◽  
Black Tea ◽  
Protective Role ◽  
Black Tea Extract ◽  
Tea Extract

Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's disease

2006 ◽  
Vol 22 (2) ◽  
pp. 421-434 ◽  
Author(s):  
R.K. Chaturvedi ◽  
S. Shukla ◽  
K. Seth ◽  
S. Chauhan ◽  
C. Sinha ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Black Tea ◽  
Black Tea Extract ◽  
Tea Extract ◽  
6 Hydroxydopamine

Protective role of black tea and vitamin C during sub-acute toxicity of carbofuran in rats

2016 ◽  
Vol 6 (2) ◽  
pp. 0-0 ◽  
Author(s):  
D. Kumar ◽  
B. Sharma ◽  
SI Rizvi
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Vitamin C ◽  
Defense Mechanism ◽  
Therapeutic Potential ◽  
Black Tea ◽  
Protective Role ◽  
Black Tea Extract ◽  
Tea Extract

Purpose: Carbofuran toxicity on rats was studied during sub-acute exposure. This work was undertaken to evaluate the protective effect of aqueous black tea extract and vitamin C against a rat model of oxidative stress induced by treatment with carbofuran, an organocarbamate insecticide. Materials and methods: The levels of lipid peroxidation, reduced glutathione and ascorbic acid were assessed by determining the extent of oxidative stress in the erythrocytes of rats. Results: The results clearly demonstrated that the treatment of rats with sub-acute concentration of carbofuran caused significant elevation in the levels of oxidative stress and decrease in the contents of glutathione and ascorbic acid. The introduction of black tea extract and vitamin C augmented the antioxidant defense mechanism in alleviating the carbofuran induced oxidative stress. Conclusion: The findings that the pretreatment with black tea and vitamin C can mitigate carbofuran induced toxicity lend evidence that supplementation with either black tea extract and/or vitamin C have a therapeutic potential in amelioration of oxidative stress in mammalian systems

scholarly journals Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson’s Disease in Asian Population: A Meta-Analysis

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 674
Author(s):  
Han-Lin Chiang ◽  
Yih-Ru Wu ◽  
Yi-Chun Chen ◽  
Hon-Chung Fung ◽  
Chiung-Mei Chen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Lewy Bodies ◽  
Asian Population ◽  
Protective Role ◽  
Lewy Neurites ◽  
Chinese Populations ◽  
Study Results

Parkinson’s disease (PD) is a neurodegenerative disease with the pathological hallmark of Lewy bodies and Lewy neurites composed of α-synuclein. The SNP rs591323 is one of the risk loci located near the FGF20 gene that has been implicated in PD. The variation of FGF20 in the 3′ untranslated region was shown to increase α-synuclein expression. We examined the association of rs591323 with the risk of PD in a Taiwanese population and conducted a meta-analysis, including our study and two other studies from China, to further confirm the role of this SNP in Taiwanese/Chinese populations. A total of 586 patients with PD and 586 health controls (HCs) were included in our study. We found that the minor allele (A) and the AA + GA genotype under the dominant model are significantly less frequent in PD than in controls. The meta-analysis consisted of 1950 patients with PD and 2073 healthy controls from three studies. There was significant association between rs591323 and the risk of PD in the additive (Z = −3.96; p < 0.0001) and the dominant models (Z = −4.01; p < 0.0001). Our study results and the meta-analysis support the possible protective role of the rs591323 A allele in PD in Taiwanese/Chinese populations.

scholarly journals The Protective Role of Brain CYP2J in Parkinson’s Disease Models

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Yueran Li ◽  
Jinhua Wu ◽  
Xuming Yu ◽  
Shufang Na ◽  
Ke Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Brain Regions ◽  
Protective Role ◽  
Neural Cells ◽  
Endogenous Substrates ◽  
6 Hydroxydopamine ◽  
Myd88 Signaling ◽  
Lps Treatment

CYP2J proteins are present in the neural cells of human and rodent brain regions. The aim of this study was to investigate the role of brain CYP2J in Parkinson’s disease. Rats received right unilateral injection with lipopolysaccharide (LPS) or 6-hydroxydopamine (6-OHDA) in the substantia nigra following transfection with or without the CYP2J3 expression vector. Compared with LPS-treated rats, CYP2J3 transfection significantly decreased apomorphine-induced rotation by 57.3% at day 12 and 47.0% at day 21 after LPS treatment; moreover, CYP2J3 transfection attenuated the accumulation of α-synuclein. Compared with the 6-OHDA group, the number of rotations by rats transfected with CYP2J3 decreased by 59.6% at day 12 and 43.5% at day 21 after 6-OHDA treatment. The loss of dopaminergic neurons and the inhibition of the antioxidative system induced by LPS or 6-OHDA were attenuated following CYP2J3 transfection. The TLR4-MyD88 signaling pathway was involved in the downregulation of brain CYP2J induced by LPS, and CYP2J transfection upregulated the expression of Nrf2 via the inhibition of miR-340 in U251 cells. The data suggest that increased levels of CYP2J in the brain can delay the pathological progression of PD initiated by inflammation or neurotoxins. The alteration of the metabolism of the endogenous substrates (e.g., AA) could affect the risk of neurodegenerative disease.

Cytochrome P450 and Parkinson’s disease: protective role of neuronal CYP 2E1 from MPTP toxicity

2006 ◽  
pp. 173-176 ◽  
Author(s):  
C. Viaggi ◽  
C. Pardini ◽  
F. Vaglini ◽  
G. U. Corsini
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cytochrome P450 ◽  
Protective Role ◽  
Cyp 2E1 ◽  
Mptp Toxicity

Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins

2018 ◽  
Vol 279 ◽  
pp. 111-120 ◽  
Author(s):  
André T.R. Goes ◽  
Cristiano R. Jesse ◽  
Michelle S. Antunes ◽  
Fernando V. Lobo Ladd ◽  
Aliny A.B. Lobo Ladd ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Protective Role ◽  
6 Hydroxydopamine

scholarly journals Protective role of microRNA-221 in Parkinson’s disease

2018 ◽  
Vol 119 (01) ◽  
pp. 22-27 ◽  
Author(s):  
L. Li ◽  
J. Xu ◽  
M. Wu ◽  
J. M. Hu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Protective Role

Black Tea Extract and its Thearubigins Relieve the Sildenafil-Induced Delayed Gut Motility in Mice: A Possible Role of Nitric Oxide

2014 ◽  
Vol 28 (11) ◽  
pp. 1687-1691 ◽  
Author(s):  
Hussam A. S. Murad ◽  
Hossam M. Abdallah
Keyword(s):  
Nitric Oxide ◽  
Black Tea ◽  
Gut Motility ◽  
Black Tea Extract ◽  
Tea Extract
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