Addressing the Complex Problem of Degradation‐Derived Mutagenic Impurities in Drug Substances and Products

2021 ◽  
pp. 477-511
Keyword(s):  
Complex Problem ◽  
Drug Substances

Complex Problem Solving and Worked Examples

2009 ◽  
Vol 23 (2) ◽  
pp. 129-138 ◽  
Author(s):  
Florian Schmidt-Weigand ◽  
Martin Hänze ◽  
Rita Wodzinski
Keyword(s):  
Problem Solving ◽  
Cognitive Load ◽  
Learning Experience ◽  
Worked Examples ◽  
Complex Problem ◽  
Complex Problem Solving ◽  
Strategic Learning ◽  
Learning Behavior ◽  
Worked Example ◽  
8Th Grade

How can worked examples be enhanced to promote complex problem solving? N = 92 students of the 8th grade attended in pairs to a physics problem. Problem solving was supported by (a) a worked example given as a whole, (b) a worked example presented incrementally (i.e. only one solution step at a time), or (c) a worked example presented incrementally and accompanied by strategic prompts. In groups (b) and (c) students self-regulated when to attend to the next solution step. In group (c) each solution step was preceded by a prompt that suggested strategic learning behavior (e.g. note taking, sketching, communicating with the learning partner, etc.). Prompts and solution steps were given on separate sheets. The study revealed that incremental presentation lead to a better learning experience (higher feeling of competence, lower cognitive load) compared to a conventional presentation of the worked example. However, only if additional strategic learning behavior was prompted, students remembered the solution more correctly and reproduced more solution steps.

The Prediction of Problem-Solving Assessed Via Microworlds

2016 ◽  
Vol 32 (4) ◽  
pp. 298-306 ◽  
Author(s):  
Samuel Greiff ◽  
Katarina Krkovic ◽  
Jarkko Hautamäki
Keyword(s):  
Working Memory ◽  
Problem Solving ◽  
Complex Problem ◽  
Two Dimensions ◽  
Assessment Instruments ◽  
Complex Problem Solving ◽  
Visual Spatial ◽  
Rule Knowledge ◽  
Rule Application ◽  
Fluid Reasoning

Abstract. In this study, we explored the network of relations between fluid reasoning, working memory, and the two dimensions of complex problem solving, rule knowledge and rule application. In doing so, we replicated the recent study by Bühner, Kröner, and Ziegler (2008) and the structural relations investigated therein [ Bühner, Kröner, & Ziegler, (2008) . Working memory, visual-spatial intelligence and their relationship to problem-solving. Intelligence, 36, 672–680]. However, in the present study, we used different assessment instruments by employing assessments of figural, numerical, and verbal fluid reasoning, an assessment of numerical working memory, and a complex problem solving assessment using the MicroDYN approach. In a sample of N = 2,029 Finnish sixth-grade students of which 328 students took the numerical working memory assessment, the findings diverged substantially from the results reported by Bühner et al. Importantly, in the present study, fluid reasoning was the main source of variation for rule knowledge and rule application, and working memory contributed only a little added value. Albeit generally in line with previously conducted research on the relation between complex problem solving and other cognitive abilities, these findings directly contrast the results of Bühner et al. (2008) who reported that only working memory was a source of variation in complex problem solving, whereas fluid reasoning was not. Explanations for the different patterns of results are sought, and implications for the use of assessment instruments and for research on interindividual differences in complex problem solving are discussed.

Development of JIT patient-specific implants

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Leanne SOBEL ◽  
Katrina SKELLERN ◽  
Kat PEREIRA
Keyword(s):  
Design Thinking ◽  
Technology Development ◽  
Complex Problem ◽  
Project Team ◽  
Healthcare Sector ◽  
Strategy Development ◽  
Patient Specific ◽  
Critical System ◽  
Patient Specific Implants ◽  
Human Centred Design

Design thinking and human-centred design is often discussed and utilised by teams and organisations seeking to develop more optimal, effective or innovative solutions for better customer outcomes. In the healthcare sector the opportunity presented by the practice of human-centred design and design thinking in the pursuit of better patient outcomes is a natural alignment. However, healthcare challenges often involve complex problem sets, many stakeholders, large systems and actors that resist change. High-levels of investment and risk aversion results in the status quo of traditional technology-led processes and analytical decision-making dominating product and strategy development. In this case study we present the opportunities, challenges and benefits that including a design-led approach in developing complex healthcare technology can bring. Drawing on interviews with participants and reflections from the project team, we explore and articulate the key learning from using a design-led approach. In particular we discuss how design-led practices that place patients at the heart of technology development facilitated the project team in aligning key stakeholders, unearthing critical system considerations, and identifying product and sector-wide opportunities.

Profaning Jewish Mores in Chochana Boukhobza's Un été à Jérusalem

2018 ◽  
Vol 57 (1) ◽  
pp. 81-91
Author(s):  
Nancy M. Arenberg
Keyword(s):  
Gender Roles ◽  
Complex Problem ◽  
Religious Practices ◽  
Her Family ◽  
Traditional Gender Roles ◽  
The City ◽  
Traditional Roles

As a transnational Israeli writer, Chochana Boukhobza delves into the complex problem of crossing borders in Un été à Jérusalem (1986), a text which focuses on the unnamed protagonist's trip from Paris to visit her family during the summer months in Jerusalem. Although the narrator had resided in Israel previously, she is forced to grapple with her ‘Otherness’ in Jerusalem, especially as a Jew originally from Tunisia. The narrator's crisis of exile is defined by her sense of disconnection to her family, the city, Israeli politics, and women's traditional roles. In this essay, particular emphasis will be placed on the protagonist's penchant for profaning Jewish cultural and religious practices, which is articulated through a series of corporeal transgressions. To launch this revolt against the patriarchal structure of the nation in Israel, the narrator rejects the submissive role assigned to Jewish-Tunisian women, and, in so doing, dismantles traditional gender roles.

URGENSI MANAJEMEN DALAM PENGEMBANGAN AKTIVITAS DAKWAH

1970 ◽  
Vol 10 (2) ◽  
pp. 278-291
Author(s):  
Wahyu Budiantoro
Keyword(s):  
Public Life ◽  
Complex Problem ◽  
Good Management ◽  
The Subject

Da’wah in practical terms, always in touch with the community. Therefore requires a specific set of supporters in achieving its objectives, namely the setting or the good management and direction. In missionary activity there will be a very complex problem, if no good management, systematic, and purposeful. Implementation of propaganda will work effectively and efficiently when it first be able to identify the problems faced by the community. Then, on the basis of control of the situation and conditions for propaganda, formulate an appropriate plan. The dynamics of the problem requires people with a variety of actors preaching able to devise a proper plan-as the basis of a movement dakwah-, and arrange and organize the subject of preaching in a certain propaganda units. To realize and ground the teachings of Islam in public life, the propaganda must be properly managed, to meet the needs of society. Dakwah dalam tataran praktis, selalu berhubungan dengan masyarakat. Oleh karenanya membutuhkan seperangkap pendukung dalam mencapai tujuan, yaitu pengaturan atau manajemen yang baik dan terarah. Dalam aktivitas dakwah akan timbul masalah yang sangat kompleks, apabila tidak dilakukan manajemen yang baik, sistematis, dan terarah. Penyelenggaraan dakwah akan berjalan dengan efektif dan efisien apabila terlebih dahulu dapat mengidentifikasi masalah-masalah yang tengah dihadapi oleh masyarakat. Kemudian, atas dasar pengendalian situasi dan kondisi tempat untuk dakwah, disusunlah suatu rencana yang tepat. Dinamika masyarakat dengan berbagai problemnya mengharuskan para pelaku dakwah mampu menyusun rencana yang tepat –sebagai dasar dari sebuah gerakan dakwah, dan mengatur dan mengorganisir subjek dakwah ke dalam kesatuankesatuan dakwah tertentu. Untuk mewujukan dan membumikan ajaran-ajaran Islam dalam kehidupan masyarakat, maka dakwah harus dikelola dengan baik, untuk memenuhi kebutuhan masyarakat.

Peculiarities of the course of the postpartum period in domestic reindeer females, its morphophysiology and behavioral reactions in the North-East of Russia (Republic of Sakha)

2020 ◽  
pp. 99-105
Author(s):  
V. Fedorov ◽  
E. Sleptsov ◽  
K. Plemyashov
Keyword(s):  
Postpartum Period ◽  
Reproductive Function ◽  
Complex Problem ◽  
Climatic Conditions ◽  
Taiga Zone ◽  
Behavioral Reactions ◽  
North East ◽  
The North ◽  
The Republic ◽  
Mountain Taiga

A growth in the number of deer and an increase in their productivity are closely related to the solution of the complex problem of reproduction and rational use of deer females. Significant damage to reindeer husbandry is caused by the barrenness of northern domestic deer, the level of which has been quite high in recent years. So, in the Republic of Sakha, on 01.01.2020, the number of domesticated reindeer was 152,068, of which female deer and heifers — 71,818, offspring per 100 females — 59, business yield amounted to 52 fawns per 100 females. The causes of infertility are very diverse, as the natural and climatic conditions of the breeding zones have a significant influence on the reproductive function of reindeer. In Yakutia, the main population of northern domestic deer is bred in mountain taiga and tundra natural-climatic zones, so there are about 55 thousand deer in the mountain taiga zone and more than 65 thousand deer in the tundra zone. In this regard, the study of the peculiarities of the postpartum period course in domestic reindeer females, its morphophysiology, and behavioral reactions depending on the natural and climatic conditions of breeding is of great importance.

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