ДІАЛОГ ЯК МЕХАНІЗМ АКСІОГЕНЕЗУ ОСОБИСТОСТІ В ПРОЦЕСІ ВИЩОЇ ПРОФЕСІЙНОЇ ОСВІТИ

1970 ◽  
Vol 8 (1) ◽  
pp. 103-109
Author(s):  
Галина Радчук
Keyword(s):  
Real Life ◽  
Educational Environment ◽  
Educational Process ◽  
Cognitive Approach ◽  
Developmental Potential ◽  
Educational Dialogue ◽  
Cultural Orientations ◽  
Teachers And Students ◽  
Stereotyped Role ◽  
Internal Initiation

Статтю  присвячено  проблемі  теоретичного  обґрунтування  діалогу  як  механізму  аксіогенезу  особистості в освітньому процесі та виокремлення сутнісних аспектів діалогізації освітнього середовища  вищої школи. Обґрунтовано, що провідними цілями сучасної вищої освіти в контексті її гуманітаризації є  загальнокультурні орієнтири, які дозволяють замінити власне  когнітивний  підхід на смислотворчий, де і  викладач, і студент є активними суб’єктами освітнього діалогу. Показано, що освітній діалог виступає  зовнішньою   спонукою   внутрішнього   ініціювання   особистісно-професійного   становлення   майбутнього  фахівця,  становлення  його  ціннісно-смислової  сфери,  а  рівень  діалогізації  освітнього  середовища  може  слугувати  мірилом  реалізації  особистісно-розвивального  потенціалу  освіти.  На  підставі  емпіричного  дослідження   визначено,  що  у   реальному   освітньому   процесі  найбільшою   перешкодою  у   діалогізації  освітнього   середовища   є      догматичність,   формалізованість   освітнього   процесу   та   закритість,  стереотипність рольової поведінки викладачів та студентів.  The  article  is  focused  on  theoretical  argumentation  of the  dialogue  as  a  mechanism  for  personality  axiogenesis in  educational process and separation of essential dialogue aspects in higher educational environment.  The author argues that general cultural orientations are main goals of modern higher education in the context of its  humanization. This allows to replace the actual cognitive approach with sense creation one, where both teacher and  student are active subjects of educational dialogue. It is shown that educational dialogue is an external stimulus of  internal initiation of personal and professional formation in future specialists, as well as formation of their value- semantic sphere. The level of dialogue in educational environment can serve as a measure of implementation of  personality and developmental potential in education. On the basis of empirical research it is determined that  dogmatism,  formalization  of  educational  process,  and  closeness,  stereotyped  role  of  teachers’  and  students’  behavior  are  the  greatest  obstacles  for  educational  environment  becoming  more  dialogue  driven  in  real-life  educational process.

scholarly journals Internal initiation of translation from the human rhinovirus-2 internal ribosome entry site requires the binding of Unr to two distinct sites on the 5′ untranslated region

2007 ◽  
Vol 88 (11) ◽  
pp. 3043-3052 ◽  
Author(s):  
Emma C. Anderson ◽  
Sarah L. Hunt ◽  
Richard J. Jackson
Keyword(s):  
Internal Ribosome Entry Site ◽  
Binding Sites ◽  
Cold Shock ◽  
Human Rhinovirus ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Polypyrimidine Tract Binding Protein ◽  
Initiation Of Translation ◽  
Cold Shock Domain ◽  
Internal Initiation

Internal initiation of translation from the human rhinovirus-2 (HRV-2) internal ribosome entry site (IRES) is dependent upon host cell trans-acting factors. The multiple cold shock domain protein Unr and the polypyrimidine tract-binding protein have been identified as synergistic activators of HRV-2 IRES-driven translation. In order to investigate the mechanism by which Unr acts in this process, we have mapped the binding sites of Unr to two distinct secondary structure domains of the HRV-2 IRES, and have identified specific nucleotides that are involved in the binding of Unr to the IRES. The data suggest that Unr acts as an RNA chaperone to maintain a complex tertiary IRES structure required for translational competency.

Ball experiments in 32 acute akinetic catatonic patients: Deficits of internal initiation and generation of movements

1995 ◽  
Vol 10 (5) ◽  
pp. 589-595 ◽  
Author(s):  
G. Northoff ◽  
J. Wenke ◽  
W. Krill ◽  
B. Pflug
Keyword(s):  
Internal Initiation

sry h-1, a new Drosophila melanogaster multifingered protein gene showing maternal and zygotic expression

1988 ◽  
Vol 8 (10) ◽  
pp. 4459-4468
Author(s):  
A Vincent ◽  
J Kejzlarovà-Lepesant ◽  
L Segalat ◽  
C Yanicostas ◽  
J A Lepesant
Keyword(s):  
Dna Sequences ◽  
Subsequent Development ◽  
Initiation Site ◽  
Protein Product ◽  
Protein Coding ◽  
Finger Protein ◽  
Early Embryos ◽  
The Family ◽  
Genes Encoding ◽  
Internal Initiation

Low-stringency hybridization of the Drosophila serendipity (sry) finger-coding sequences revealed copies of homologous DNA sequences in the genomes of members of the family Drosophilidae and higher vertebrates. sry h-1, a new Drosophila finger protein-coding gene isolated on the basis of this homology, encodes a 3.2-kilobase (kb) mRNA accumulating in eggs and abundant in early embryos. The predicted sry h-1 protein product, starting at an internal initiation site of translation, is a 868-amino-acid basic polypeptide containing eight TFIIIA-like fingers encoded by three separate exons. Links separating individual fingers in the sry h-1 protein are variable in length and sequence, in contrast with the invariant H/C link found in most multi-fingered proteins. The similarity of the developmental pattern of transcription of sry h-1 with that of several other Drosophila finger protein genes suggests the existence of a complex set of such genes encoding an information which is, at least partly, maternally provided to the embryo and required for activation of gene transcription in early embryos or maintenance of gene activity during subsequent development.

scholarly journals BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1

2020 ◽  
Vol 6 (47) ◽  
pp. eabd2163
Author(s):  
Youngseob Jung ◽  
Ji-Young Seo ◽  
Hye Guk Ryu ◽  
Do-Yeon Kim ◽  
Kyung-Ha Lee ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Molecular Mechanisms ◽  
Receptor Expression ◽  
Spine Density ◽  
Entry Site ◽  
Independent Manner ◽  
Internal Ribosome Entry ◽  
Ampa Receptor Subunit ◽  
Internal Initiation ◽  
Underlying Mechanisms

The AMPA receptor subunit GluA1 is essential for induction of synaptic plasticity. While various regulatory mechanisms of AMPA receptor expression have been identified, the underlying mechanisms of GluA1 protein synthesis are not fully understood. In neurons, axonal and dendritic mRNAs have been reported to be translated in a cap-independent manner. However, molecular mechanisms of cap-independent translation of synaptic mRNAs remain largely unknown. Here, we show that GluA1 mRNA contains an internal ribosome entry site (IRES) in the 5′UTR. We also demonstrate that heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 interacts with GluA1 mRNA and mediates internal initiation of GluA1. Brain-derived neurotrophic factor (BDNF) stimulation increases IRES-mediated GluA1 translation via up-regulation of HNRNP A2/B1. Moreover, BDNF-induced GluA1 expression and dendritic spine density were significantly decreased in neurons lacking hnRNP A2/B1. Together, our data demonstrate that IRES-mediated translation of GluA1 mRNA is a previously unidentified feature of local expression of the AMPA receptor.

Internal initiation of picornavirus RNA translation

1993 ◽  
Vol 4 (4) ◽  
pp. 217-227 ◽  
Author(s):  
Karen Meerovitch ◽  
Nahum Sonenberg
Keyword(s):  
Rna Translation ◽  
Internal Initiation

An Erythroid-Specific Transcript Generates the Soluble Form of NADH-Cytochrome b5 Reductase in Humans

Blood ◽  
1998 ◽  
Vol 92 (1) ◽  
pp. 310-319 ◽  
Author(s):  
Alessandra Bulbarelli ◽  
Alessandra Valentini ◽  
Marcella DeSilvestris ◽  
M. Domenica Cappellini ◽  
Nica Borgese
Keyword(s):  
Cytochrome B5 ◽  
K562 Cells ◽  
Soluble Form ◽  
Rnase Protection ◽  
Cytochrome B5 Reductase ◽  
Erythroid Maturation ◽  
Nadh Cytochrome ◽  
Internal Initiation ◽  
Late Stages

Two forms of NADH-cytochrome b5 reductase (b5R), an erythrocyte-restricted soluble form, active in methemoglobin reduction, and a ubiquitous membrane-associated form involved in lipid metabolism, are produced from one gene. In the rat, the two forms are generated from alternative transcripts differing in the first exon, however, biogenesis of human b5R was less understood. Recently, two different transcripts (M and S), differing in the first exon were also described in humans. Here, we have investigated the tissue-specificity and the role of the S-transcript in the generation of soluble b5R. By RNase protection assays designed to simultaneously detect alternative b5R transcripts in the same sample, the S transcript was undetectable in nonerythroid and in erythroleukemic K562 cells induced to differentiate, but was present in terminal erythroblast cultures, and represented a major b5R transcript in reticulocytes. Analysis of the translation products of the M- and S-transcripts in HeLa cells transfected with the corresponding cDNAs demonstrated that the S-transcript generates soluble b5R, presumably from an internal initiation codon. Our results indicate that the S-transcript is expressed at late stages of erythroid maturation to generate soluble b5R.

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