Solid Free-Form Fabrication of Tissue-Engineering Scaffolds with a Poly(lactic-co-glycolic acid) Grafted Hyaluronic Acid Conjugate Encapsulating an Intact Bone Morphogenetic Protein-2/Poly(ethylene glycol) Complex

2011 ◽  
Vol 21 (15) ◽  
pp. 2906-2912 ◽  
Author(s):  
Jung Kyu Park ◽  
Jin-Hyung Shim ◽  
Kyung Shin Kang ◽  
Junseok Yeom ◽  
Ho Sang Jung ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Bone Morphogenetic Protein 2 ◽  
Free Form ◽  
Poly Ethylene Glycol ◽  
Tissue Engineering Scaffolds ◽  
Morphogenetic Protein ◽  
Intact Bone ◽  
Acid Conjugate ◽  
Poly Ethylene ◽  
Solid Free Form Fabrication

scholarly journals Modular, tissue-specific, and biodegradable hydrogel cross-linkers for tissue engineering

2019 ◽  
Vol 5 (6) ◽  
pp. eaaw7396 ◽  
Author(s):  
J. L. Guo ◽  
Y. S. Kim ◽  
V. Y. Xie ◽  
B. T. Smith ◽  
E. Watson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Glycolic Acid ◽  
Modular Design ◽  
Cell Encapsulation ◽  
Poly Ethylene Glycol ◽  
Tissue Specific ◽  
Biological Responses ◽  
Morphogenetic Protein ◽  
Biodegradable Hydrogel ◽  
Poly Ethylene

Synthetic hydrogels are investigated extensively in tissue engineering for their tunable physicochemical properties but are bioinert and lack the tissue-specific cues to produce appropriate biological responses. To introduce tissue-specific biochemical cues to these hydrogels, we have developed a modular hydrogel cross-linker, poly(glycolic acid)–poly(ethylene glycol)–poly(glycolic acid)-di(but-2-yne-1,4-dithiol) (PdBT), that can be functionalized with small peptide-based cues and large macromolecular cues simply by mixing PdBT in water with the appropriate biomolecules at room temperature. Cartilage- and bone-specific PdBT macromers were generated by functionalization with a cartilage-associated hydrophobic N-cadherin peptide, a hydrophilic bone morphogenetic protein peptide, and a cartilage-derived glycosaminoglycan, chondroitin sulfate. These biofunctionalized PdBT macromers can spontaneously cross-link polymers such as poly(N-isopropylacrylamide) to produce rapidly cross-linking, highly swollen, cytocompatible, and hydrolytically degradable hydrogels suitable for mesenchymal stem cell encapsulation. These favorable properties, combined with PdBT’s modular design and ease of functionalization, establish strong potential for its usage in tissue engineering applications.

scholarly journals Transplanted Bone Morphogenetic Protein/Poly(lactic-co-glycolic Acid) Delayed-release Microcysts Combined with Rat Micromorselized Bone and Collagen for Bone Tissue Engineering

2009 ◽  
Vol 37 (4) ◽  
pp. 1075-1087 ◽  
Author(s):  
Y Ji ◽  
GP Xu ◽  
JL Yan ◽  
SH Pan
Keyword(s):  
Bone Morphogenetic Protein ◽  
Glycolic Acid ◽  
Gluteus Maximus ◽  
The Other ◽  
Bone Morphogenetic Protein 2 ◽  
Bone Collagen ◽  
Delayed Release ◽  
Morphogenetic Protein ◽  
Gluteus Maximus Muscle ◽  
Autologous Bone

This study was designed to optimize the preparation of delayed-release microcysts containing bone morphogenetic protein 2 (BMP-2) combined with poly(lactic- co-glycolic acid) (PLGA) and to investigate their osteogenic properties when combined with rat autologous micromorselized bone and collagen. Rat autologous micromorselized bone, collagen and BMP-2/PLGA delayed-release microcysts were implanted in various combinations into the rat gluteus maximus muscle sack model. The following post-operative measurements were made: general observations of the implant site, histological observations, osteogenesis measurements and alkaline phosphatase activity. Autologous micromorselized bone combined with collagen and BMP-2/PLGA delayed-release microcysts demonstrated significantly superior osteogenic properties than any of the other combinations of these three components. These findings suggest that micromorselized bone combined with collagen and BMP-2/PLGA delayed-release microcysts could reduce the quantity of BMP-2 and autologous bone required for these procedures, making their use feasible in human bone restoration.

Modification of Poly(lactic/glycolic acid) Surface by Chemical Attachment of Poly(ethylene glycol)

Langmuir ◽  
2010 ◽  
Vol 26 (3) ◽  
pp. 1440-1444 ◽  
Author(s):  
É. Kiss ◽  
E. Kutnyánszky ◽  
I. Bertóti
Keyword(s):  
Ethylene Glycol ◽  
Glycolic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
Sign in / Sign up

Export Citation Format

Share Document