Synergistic Antibacterial and Anti‐Inflammatory Effects of a Drug‐Loaded Self‐Standing Porphyrin‐COF Membrane for Efficient Skin Wound Healing

2021 ◽  
pp. 2001821
Author(s):  
Luo‐Gang Ding ◽  
Song Wang ◽  
Bing‐Jian Yao ◽  
Fei Li ◽  
Yan‐An Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Anti Inflammatory

Chondroitin sulfate zinc with antibacterial properties and anti-inflammatory effects for skin wound healing

2021 ◽  
pp. 118996
Author(s):  
Guofeng Wu ◽  
Fenbo Ma ◽  
Yizhebang Xue ◽  
Ying Peng ◽  
Liqiu Hu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chondroitin Sulfate ◽  
Antibacterial Properties ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Anti Inflammatory

scholarly journals Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

2020 ◽  
Vol 17 (11) ◽  
pp. 4160 ◽  
Author(s):  
Nusaibah Sallehuddin ◽  
Abid Nordin ◽  
Ruszymah Bt Hj Idrus ◽  
Mh Busra Fauzi
Keyword(s):  
Wound Healing ◽  
Nigella Sativa ◽  
Healing Process ◽  
Skin Wound ◽  
Tissue Growth ◽  
Inclusion Criteria ◽  
Skin Wound Healing ◽  
In Vivo Animal Model ◽  
Anti Inflammatory

Nigella sativa (NS) has been reported to have a therapeutic effect towards skin wound healing via its anti-inflammatory, tissue growth stimulation, and antioxidative properties. This review examines all the available studies on the association of Nigella sativa (NS) and skin wound healing. The search was performed in Medline via EBSCOhost and Scopus databases to retrieve the related papers released between 1970 and March 2020. The principal inclusion criteria were original article issued in English that stated wound healing criteria of in vivo skin model with topically applied NS. The search discovered 10 related articles that fulfilled the required inclusion criteria. Studies included comprise different types of wounds, namely excisional, burn, and diabetic wounds. Seven studies unravelled positive results associated with NS on skin wound healing. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to wound healing process.

Antioxidant and anti-inflammatory activities of Prussian blue nanozyme promotes full-thickness skin wound healing

2021 ◽  
Vol 119 ◽  
pp. 111596
Author(s):  
Abhishek Sahu ◽  
Jin Jeon ◽  
Min Suk Lee ◽  
Hee Seok Yang ◽  
Giyoong Tae
Keyword(s):  
Wound Healing ◽  
Prussian Blue ◽  
Skin Wound ◽  
Full Thickness ◽  
Skin Wound Healing ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Anti Inflammatory

scholarly journals Effects of Sapindus mukorossi Seed Oil on Skin Wound Healing: In Vivo and in Vitro Testing

2019 ◽  
Vol 20 (10) ◽  
pp. 2579 ◽  
Author(s):  
Chang-Chih Chen ◽  
Chia-Jen Nien ◽  
Lih-Geeng Chen ◽  
Kuen-Yu Huang ◽  
Wei-Jen Chang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cell Proliferation ◽  
Wound Healing ◽  
Seed Oil ◽  
Skin Wound ◽  
Skin Wounds ◽  
Skin Wound Healing ◽  
Anti Inflammatory

Sapindus mukorossi seed oil is commonly used as a source for biodiesel fuel. Its phytochemical composition is similar to the extracted oil from Sapindus trifoliatus seeds, which exhibit beneficial effects for skin wound healing. Since S. mukorossi seed shows no cyanogenic property, it could be a potential candidate for the treatment of skin wounds. Thus, we evaluated the effectiveness of S. mukorossi seed oil in the treatment of skin wounds. We characterized and quantified the fatty acids and unsaponifiable fractions (including β-sitosterol and δ-tocopherol) contained in S. mukorossi seed-extracted oil by GC-MS and HPLC, respectively. Cell proliferation and migratory ability were evaluated by cell viability and scratch experiments using CCD-966SK cells treated with S. mukorossi oil. The anti-inflammatory effects of the oil were evaluated by measuring the nitric oxide (NO) production in lipopolysaccharide-treated RAW 264.7 cells. Antimicrobial activity tests were performed with Propionibacterium acnes, Staphylococcus aureus, and Candida albicans using a modified Japanese Industrial Standard procedure. Uniform artificial wounds were created on the dorsum of rats. The wounds were treated with a carboxymethyl cellulose (CMC)/hyaluronic acid (HA)/sodium alginate (SA) hydrogel for releasing the S. mukorossi seed oil. The wound sizes were measured photographically for 12 days and were compared to wounds covered with analogous membranes containing a saline solution. Our results showed that the S. mukorossi seed oil used in this study contains abundant monounsaturated fatty acids, β-sitosterol, and δ-tocopherol. In the in vitro tests, S. mukorossi seed oil prompted cell proliferation and migration capability. Additionally, the oil had significant anti-inflammatory and anti-microbial activities. In the in vivo animal experiments, S. mukorossi seed oil-treated wounds revealed acceleration of sequential skin wound healing events after two days of healing. The size of oil-treated wound decreased to half the size of the untreated control after eight days of healing. The results suggest that S. mukorossi seed oil could be a potential source for promoting skin wound healing.

scholarly journals Octenidine-based hydrogel shows anti-inflammatory and protease-inhibitory capacities in wounded human skin

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Saskia Seiser ◽  
Lukas Janker ◽  
Nina Zila ◽  
Michael Mildner ◽  
Ana Rakita ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Ex Vivo ◽  
Skin Wound ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tape Stripping ◽  
Skin Wound Healing ◽  
Wound Model ◽  
Octenidine Dihydrochloride ◽  
Anti Inflammatory

AbstractOctenidine dihydrochloride (OCT) is a widely used antiseptic molecule, promoting skin wound healing accompanied with improved scar quality after surgical procedures. However, the mechanisms by which OCT is contributing to tissue regeneration are not yet completely clear. In this study, we have used a superficial wound model by tape stripping of ex vivo human skin. Protein profiles of wounded skin biopsies treated with OCT-containing hydrogel and the released secretome were analyzed using liquid chromatography-mass spectrometry (LC–MS) and enzyme-linked immunosorbent assay (ELISA), respectively. Proteomics analysis of OCT-treated skin wounds revealed significant lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines (IL-8, IL-6) and matrix-metalloproteinases (MMP1, MMP2, MMP3, MMP9) when compared to controls. In addition, enzymatic activity of several released MMPs into culture supernatants was significantly lower in OCT-treated samples. Our data give insights on the mode of action based on which OCT positively influences wound healing and identified anti-inflammatory and protease-inhibitory activities of OCT.

scholarly journals Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2819 ◽  
Author(s):  
Fernando Pereira Beserra ◽  
Meilang Xue ◽  
Gabriela Maia ◽  
Ariane Leite Rozza ◽  
Cláudia Helena Pellizzon ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Therapeutic Potential ◽  
Collagen Gel ◽  
Skin Wound ◽  
Dermal Fibroblasts ◽  
Pentacyclic Triterpene ◽  
Skin Wound Healing ◽  
Anti Inflammatory

Skin wound healing is a dynamic and complex process involving several mediators at the cellular and molecular levels. Lupeol, a phytoconstituent belonging to the triterpenes class, is found in several fruit plants and medicinal plants that have been the object of study in the treatment of various diseases, including skin wounds. Various medicinal properties of lupeol have been reported in the literature, including anti-inflammatory, antioxidant, anti-diabetic, and anti-mutagenic effects. We investigated the effects of lupeol (0.1, 1, 10, and 20 μg/mL) on in vitro wound healing assays and signaling mechanisms in human neonatal foreskin keratinocytes and fibroblasts. Results showed that, at high concentrations, Lupeol reduced cell proliferation of both keratinocytes and fibroblasts, but increased in vitro wound healing in keratinocytes and promoted the contraction of dermal fibroblasts in the collagen gel matrix. This triterpene positively regulated matrix metalloproteinase (MMP)-2 and inhibited the NF-κB expression in keratinocytes, suggesting an anti-inflammatory effect. Lupeol also modulated the expression of keratin 16 according to the concentration tested. Additionally, in keratinocytes, lupeol treatment resulted in the activation of Akt, p38, and Tie-2, which are signaling proteins involved in cell proliferation and migration, angiogenesis, and tissue repair. These findings suggest that lupeol has therapeutic potential for accelerating wound healing.

scholarly journals Phytochemical Characterization, Pharmacological Properties And Toxicity of Amazonian Fruit Cubiu (Solanum Sessiliflorum Dunal)

2021 ◽  
Author(s):  
Jéssica Franco Dalenogare ◽  
Sabrina Somacal ◽  
Vanessa Schopf Machado ◽  
Greice Franciele Feyh dos Santos Montagner ◽  
Camila Marina Verdi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Inflammatory Cytokine ◽  
Skin Wound ◽  
Pharmacological Properties ◽  
Oxygen Species ◽  
Skin Wound Healing ◽  
Scratch Assay ◽  
Cytokine Levels ◽  
Anti Inflammatory

Abstract The cubiu (Solanum sessiliflorum) is a tropical fruit native to the Amazon region and widely used in medicine and cosmetics, despite the lack of research regarding the actual safety and effectiveness of its use for these purposes. This study aimed to evaluated the phytochemical characterization, pharmacological properties (skin wound healing, antimicrobial and anti-inflammatory properties), and toxicity of cubiu extract. The cubiu antimicrobial capacity was determined against strains of Aeromonas caviae, Pseudomonas aeruginosa, and Sphingomonas paucimobilis. Additionally, cubiu toxicity (hemolysis, coagulation, cell viability, and genotoxicity tests), antioxidant activity (reactive oxygen species total levels), scratch assay (in vitro skin wound healing), and anti-inflammatory activity against phytohemagglutinin and in the scratch assay (Interleukin 1, interleukin 6, interleukin 10, tumor necrosis factor-alpha, and interferon-gamma levels), were evaluated. Human fibroblast cells were used to evaluate skin wound healing, and human peripheral blood mononuclear cells were used for the other assessments. Our findings showed that the cubiu extract is rich in phenolic compounds, the major compound being 5-caffeoylquinic acid. In addition, was effective against the three bacterial strains tested and inhibited and destroyed the biofilm formed by Pseudomonas aeruginosa. The cubiu extract also was no toxicity, maintained the hemocompatibility parameters in the biological range, improved cell viability, decreased reactive oxygen species total levels and pro-inflammatory cytokine levels, increased anti-inflammatory cytokine levels, and accelerated the wound healing process. In conclusion, this is the first research to prove that cubiu is an important compound for use in the skin diseases, promoting skin wound healing, antimicrobial and anti-inflammatory activities.

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