Organic semiconductors are suitable for application in biosensors and sensors based on transistors. The influence of soluble group modifications on the performance of diketopyrrolopyrrole-based organic field-effect transistors (OFETs) is studied. The lowest mobility 1·10-9 cm2/Vs was observed for non-symmetric substitution O,N. Measurable charge carrier mobility was observed due to reduction of the density charge trapping states after application of organosilane self-assembled monolayers (SAMs) on thinner gate-dielectrics (90 nm). We report similar drift mobility 1·10-7 cm2/Vs for smallest soluble group “butyl” as for biggest group “EthylAdamantyl” in N,N and O,O substitution prepared by spin-coating.