Advances in polymeric micelles for drug delivery and tumor targeting

2010 ◽  
Vol 6 (6) ◽  
pp. 714-729 ◽  
Author(s):  
Uttam Kedar ◽  
Prasanna Phutane ◽  
Supriya Shidhaye ◽  
Vilasrao Kadam
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Polymeric Micelles

scholarly journals Drug Delivery: Dimeric Drug Polymeric Micelles with Acid‐Active Tumor Targeting and FRET‐Traceable Drug Release (Adv. Mater. 3/2018)

2018 ◽  
Vol 30 (3) ◽  
pp. 1870020 ◽  
Author(s):  
Xing Guo ◽  
Lin Wang ◽  
Kayla Duval ◽  
Jing Fan ◽  
Shaobing Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
Polymeric Micelles

scholarly journals Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform

2016 ◽  
Vol 4 (3) ◽  
pp. 511-521 ◽  
Author(s):  
Vitaliy Kapishon ◽  
Stephanie Allison ◽  
Ralph A. Whitney ◽  
Michael F. Cunningham ◽  
Myron R. Szewczuk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Radical Polymerization ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Living Radical Polymerization ◽  
Delivery Platform

Synthetic steps and subsequent preparation of oseltamivir-conjugated micelles capable of targeting and triggering receptor-induced endocytosis in cancer cells.

Strategies for Conjugation of Biomolecules to Nanoparticles as Tumor Targeting Agents

2019 ◽  
Vol 25 (37) ◽  
pp. 3917-3926
Author(s):  
Sajjad Molavipordanjani ◽  
Seyed Jalal Hosseinimehr
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Medical Imaging ◽  
Cancer Diagnosis ◽  
Carbon Nanoparticles ◽  
Tumor Targeting ◽  
Polymeric Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Active Targeting ◽  
Cancer Diagnosis And Therapy

Combination of nanotechnology, biochemistry, chemistry and biotechnology provides the opportunity to design unique nanoparticles for tumor targeting, drug delivery, medical imaging and biosensing. Nanoparticles conjugated with biomolecules such as antibodies, peptides, vitamins and aptamer can resolve current challenges including low accumulation, internalization and retention at the target site in cancer diagnosis and therapy through active targeting. In this review, we focus on different strategies for conjugation of biomolecules to nanoparticles such as inorganic nanoparticles (iron oxide, gold, silica and carbon nanoparticles), liposomes, lipid and polymeric nanoparticles and their application in tumor targeting.

Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy

2020 ◽  
Vol 13 ◽  
Author(s):  
Rohit Bhatia ◽  
Amit Sharma ◽  
Raj Kumar Narang ◽  
Ravindra K. Rawal
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Mesoporous Silica Nanoparticles ◽  
Treatment Strategies ◽  
Human Beings ◽  
The Past ◽  
Organ Systems ◽  
Metal Organic ◽  
Continuous Progress ◽  
Chemotherapeutic Treatment

: Cancer is one of the most serious health concerns in 21st century whose prevalence is beyond boundaries and can affect any organ of human beings. The conventional chemotherapeutic treatment strategies lack specificity to tumours and are associated with toxic effects on immune system and other organ systems. In the past decades, there has been a continuous progress in the development of smart nanocarrier systems for target specific delivery of drugs against variety of tumours including intracellular gene-specific targeting. These nanocarriers are able to recognize the tumour cells and deliver the therapeutic agent in fixed proportions causing no or very less harm to healthy cells. Nanosystems have modified physicochemical properties, improved bioavailability and long retention in blood which enhances their potency. A huge number of nanocarrier based formulations have been developed and are in clinical trials. Nanocarrier systems include polymeric micelles, liposomes, dendrimers, carbon nanotubes, gold nanoparticles, etc. Recent advancements in nanocarrier systems include mesoporous silica nanoparticles (MSNs), metal organic frame works and quantum dots. In the present review, various nanocarrier based drug delivery systems along with their applications in the management of cancer have been described with special emphasis on MSNs.

“Smart” Nanocarriers: A New Paradigm for Tumor Targeting Drug Delivery Systems

2011 ◽  
Vol 1 (1) ◽  
pp. 67-84
Author(s):  
Zhigang Hu ◽  
Fei Huo ◽  
Yi Zhang ◽  
Chunyang Chen ◽  
Kehua Tu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Paradigm

Core-crosslinked polymeric micelles for drug delivery

2018 ◽  
Vol 14 (5) ◽  
pp. 1842
Author(s):  
Xuelian Guo ◽  
Zhewen Yu ◽  
Rong Jin ◽  
Aoneng Cao
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles

scholarly journals Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 725
Author(s):  
Yuseon Shin ◽  
Patihul Husni ◽  
Kioh Kang ◽  
Dayoon Lee ◽  
Sehwa Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Design ◽  
Solid Tumors ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Efficacy And Safety ◽  
Stimulus Responsive ◽  
External Signals

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

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