In Situ Modification of the Tumor Cell Surface with Immunomodulating Nanoparticles for Effective Suppression of Tumor Growth in Mice

2019 ◽  
pp. 1902542 ◽  
Author(s):  
Chunxiong Zheng ◽  
Qixue Wang ◽  
Ying Wang ◽  
Xinzhi Zhao ◽  
Kaimin Gao ◽  
...  
Keyword(s):  
Cell Surface ◽  
Tumor Growth ◽  
Tumor Cell ◽  
In Situ Modification ◽  
Effective Suppression

scholarly journals Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis

2002 ◽  
Vol 99 (2) ◽  
pp. 568-573 ◽  
Author(s):  
D. Liu ◽  
Z. Shriver ◽  
G. Venkataraman ◽  
Y. El Shabrawi ◽  
R. Sasisekharan
Keyword(s):  
Cell Surface ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Heparan Sulfate ◽  
Tumor Growth And Metastasis ◽  
Cryptic Promoters

scholarly journals Tetraiodothyroacetic Acid (Tetrac) and Nanoparticulate Tetrac Arrest Growth of Medullary Carcinoma of the Thyroid

2010 ◽  
Vol 95 (4) ◽  
pp. 1972-1980 ◽  
Author(s):  
M. Yalcin ◽  
E. Dyskin ◽  
L. Lansing ◽  
D. J. Bharali ◽  
S. S. Mousa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Surface ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Nude Mouse ◽  
Cell Mass ◽  
Xenograft Model ◽  
Cell Surface Receptor ◽  
Mouse Xenograft ◽  
Mouse Xenograft Model

Abstract Context: Tetraiodothyroacetic acid (tetrac) blocks angiogenic and tumor cell proliferation actions of thyroid hormone initiated at the cell surface hormone receptor on integrin αvβ3. Tetrac also inhibits angiogenesis initiated by vascular endothelial growth factor and basic fibroblast growth factor. Objective: We tested antiangiogenic and antiproliferative efficacy of tetrac and tetrac nanoparticles (tetrac NP) against human medullary thyroid carcinoma (h-MTC) implants in the chick chorioallantoic membrane (CAM) and h-MTC xenografts in the nude mouse. Design: h-MTC cells were implanted in the CAM model (n = 8 per group); effects of tetrac and tetrac NP at 1 μg/CAM were determined on tumor angiogenesis and tumor growth after 8 d. h-MTC cells were also implanted sc in nude mice (n = 6 animals per group), and actions on established tumor growth of unmodified tetrac and tetrac NP ip were determined. Results: In the CAM, tetrac and tetrac NP inhibited tumor growth and tumor-associated angiogenesis. In the nude mouse xenograft model, established 450–500 mm3 h-MTC tumors were reduced in size over 21 d by both tetrac formulations to less than the initial cell mass (100 mm3). Tumor tissue hemoglobin content of xenografts decreased by 66% over the course of administration of each drug. RNA microarray and quantitative real-time PCR of tumor cell mRNAs revealed that both tetrac formulations significantly induced antiangiogenic thrombospondin 1 and apoptosis activator gene expression. Conclusions: Acting via a cell surface receptor, tetrac and tetrac NP inhibit growth of h-MTC cells and associated angiogenesis in CAM and mouse xenograft models.

scholarly journals Study of Tumor Growth under Hyperthermia Condition

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Qing Zhu ◽  
Aili Zhang ◽  
Ping Liu ◽  
Lisa X. Xu
Keyword(s):  
Tumor Growth ◽  
Tumor Cell ◽  
Thermal Conditions ◽  
Metastatic Tumor ◽  
Numerical Results ◽  
Initial Stage ◽  
Tumor Hyperthermia ◽  
Cell Doubling Time

The new concept of keeping primary tumor under controlin situto suppress distant foci sheds light on the treatment of metastatic tumor. Hyperthermia is considered as one of the means for controlling tumor growth. To simulate the tumor growth, a continuum mathematical model has been introduced. The newest understanding of the Warburg effect on the cellular metabolism and diffusion of the nutrients in the tissue has been taken into consideration. The numerical results are compared with thein vivoexperimental data by fitting the tumor cell doubling time/tumor cell growth rate under different thermal conditions. Both the tumor growth curve and corresponding average glucose concentration have been predicted. The numerical results have quantitatively illustrated the controlling effect on tumor growth under hyperthermia condition in the initial stage.

Cathepsin E Prevents Tumor Growth and Metastasis by Catalyzing the Proteolytic Release of Soluble TRAIL from Tumor Cell Surface

2007 ◽  
Vol 67 (22) ◽  
pp. 10869-10878 ◽  
Author(s):  
Tomoyo Kawakubo ◽  
Kuniaki Okamoto ◽  
Jun-ichi Iwata ◽  
Masashi Shin ◽  
Yoshiko Okamoto ◽  
...  
Keyword(s):  
Cell Surface ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Cathepsin E ◽  
Tumor Growth And Metastasis ◽  
Soluble Trail

In-situ Modification of Graphene Oxide by Insoluble Sulfur and Application for Nitrile Butadiene Rubber

2020 ◽  
Vol 35 (2) ◽  
pp. 221-228
Author(s):  
S.-B. Chen ◽  
T.-X. Li ◽  
S.-H. Wan ◽  
X. Huang ◽  
S.-W. Cai ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Butadiene Rubber ◽  
Nitrile Butadiene Rubber ◽  
In Situ Modification

scholarly journals Seawater Absorption and Adhesion Properties of Hydrophobic and Superhydrophobic Thermoset Epoxy Nanocomposite Coatings

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 272
Author(s):  
Ayman M. Atta ◽  
Mohamed H. El-Newehy ◽  
Meera Moydeen Abdulhameed ◽  
Mohamed H. Wahby ◽  
Ahmed I. Hashem
Keyword(s):  
Thermal Stability ◽  
Oleic Acid ◽  
Salt Spray ◽  
Adhesion Properties ◽  
In Situ Modification ◽  
Long Time ◽  
Seawater Environment ◽  
Thermoset Epoxy ◽  
The Cost

The enhancement of both thermal and mechanical properties of epoxy materials using nanomaterials becomes a target in coating of the steel to protect it from aggressive environmental conditions for a long time, with reducing the cost. In this respect, the adhesion properties of the epoxy with the steel surfaces, and its proper superhyrophobicity to repel the seawater humidity, can be optimized via addition of green nanoparticles (NPs). In-situ modification of silver (Ag) and calcium carbonate (CaCO3) NPs with oleic acid (OA) was carried out during the formation of Ag−OA and CaCO3−OA, respectively. The epoxide oleic acid (EOA) was also used as capping for Ca−O3 NPs by in-situ method and epoxidation of Ag−OA NPs, too. The morphology, thermal stability, and the diameters of NPs, as well as their dispersion in organic solvent, were investigated. The effects of the prepared NPs on the exothermic curing of the epoxy resins in the presence of polyamines, flexibility or rigidity of epoxy coatings, wettability, and coatings durability in aggressive seawater environment were studied. The obtained results confirmed that the proper superhyrophobicity, coating adhesion, and thermal stability of the epoxy were improved after exposure to salt spray fog for 2000 h at 36 °C.

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