Poly(ethylene glycol)-based amphiphilic networks and their swelling properties

We report on the successful preparation of wet dressings hydrogels based on Chitosan-Poly(N-Vinyl-Pyrrolidone)-Poly(ethylene glycol)-Poly(acrylic acid) and Poly(ethylene oxide) by e-beam cross-linking in weakly acidic media, to be used for rapid healing and pain release of infected skin wounds. The structure and compositions of hydrogels investigated according to sol-gel and swelling studies, network parameters, as well as FTIR and XPS analyses showed the efficient interaction of the hydrogel components upon irradiation, maintaining the bonding environment while the cross-linking degree increasing with the irradiation dose and the formation of a structure with the mesh size in the range 11-67 nm. Hydrogels with gel fraction above 85% and the best-swelling properties in different pH solutions were obtained for hydrogels produced with 15 kGy. The hydrogels are stable in the simulated physiological condition of an infected wound and show appropriate moisture retention capability and the water vapor transmission rate up to 272.67 g m-2 day-1, to ensure fast healing. The hydrogels proved to have a significant loading capacity of ibuprofen (IBU), being able to incorporate a therapeutic dose for the treatment of severe pains. Simultaneously, IBU was released up to 25% in the first 2h, having a release maximum after 8h.

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One Step e-Beam Radiation Cross-Linking of Quaternary Hydrogels Dressings Based on Chitosan-Poly(Vinyl-Pyrrolidone)-Poly(Ethylene Glycol)-Poly(Acrylic Acid)

International Journal of Molecular Sciences ◽

10.3390/ijms21239236 ◽

2020 ◽

Vol 21 (23) ◽

pp. 9236

Author(s):

Ion Călina ◽

Maria Demeter ◽

Anca Scărișoreanu ◽

Veronica Sătulu ◽

Bogdana Mitu

Keyword(s):

Acrylic Acid ◽

Ethylene Glycol ◽

Transmission Rate ◽

Vinyl Pyrrolidone ◽

Cross Linking ◽

Poly Ethylene Glycol ◽

Beam Radiation ◽

Swelling Properties ◽

Poly Ethylene ◽

Poly Acrylic Acid

We report on the successful preparation of wet dressings hydrogels based on Chitosan-Poly(N-Vinyl-Pyrrolidone)-Poly(ethylene glycol)-Poly(acrylic acid) and Poly(ethylene oxide) by e-beam cross-linking in weakly acidic media, to be used for rapid healing and pain release of infected skin wounds. The structure and compositions of hydrogels investigated according to sol-gel and swelling studies, network parameters, as well as FTIR and XPS analyses showed the efficient interaction of the hydrogel components upon irradiation, maintaining the bonding environment while the cross-linking degree increasing with the irradiation dose and the formation of a structure with the mesh size in the range 11–67 nm. Hydrogels with gel fraction above 85% and the best swelling properties in different pH solutions were obtained for hydrogels produced with 15 kGy. The hydrogels are stable in the simulated physiological condition of an infected wound and show appropriate moisture retention capability and the water vapor transmission rate up to 272.67 g m−2 day−1, to ensure fast healing. The hydrogels proved to have a significant loading capacity of ibuprofen (IBU), being able to incorporate a therapeutic dose for the treatment of severe pains. Simultaneously, IBU was released up to 25% in the first 2h, having a release maximum after 8 h.

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Poly (Ethylene Glycol)-Based Hydrogels as Self-Inflating Tissue Expanders with Tunable Mechanical and Swelling Properties

Macromolecular Bioscience ◽

10.1002/mabi.201600479 ◽

2017 ◽

Vol 17 (8) ◽

pp. 1600479 ◽

Cited By ~ 9

Author(s):

Mahsa Jamadi ◽

Parvin Shokrollahi ◽

Behzad Houshmand ◽

Mortaza Daliri Joupari ◽

Fatemeh Mashhadiabbas ◽

...

Keyword(s):

Ethylene Glycol ◽

Poly Ethylene Glycol ◽

Swelling Properties ◽

Tissue Expanders ◽

Poly Ethylene

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Hemocompatibility and swelling studies of poly(2-hydroxyethyl methacrylate-co-itaconic acid-co-poly(ethylene glycol) dimethacrylate) hydrogels

Hemijska industrija ◽

10.2298/hemind111005102d ◽

2011 ◽

Vol 65 (6) ◽

pp. 675-685 ◽

Cited By ~ 8

Author(s):

Sava Dobic ◽

Jovana Jovasevic ◽

Marija Vojisavljevic ◽

Simonida Tomic

Keyword(s):

Molecular Weight ◽

Ethylene Glycol ◽

Cell Viability ◽

Itaconic Acid ◽

Hydroxyethyl Methacrylate ◽

Poly Ethylene Glycol ◽

Swelling Properties ◽

Swelling Studies ◽

Poly Ethylene

In this study novel series of hydrogels, based on 2-hydroxyethyl methacrylate (HEMA), itaconic acid (IA) and poly(ethylene glycol) dimethacrylates (PEGDMA) (of varying molecular weight and concentration) were prepared by free radical crosslinking copolymerization. Preliminary hemocompatibility characterization of hydrogels obtained by hemolytic activity assay indicated good compatibility with blood. Preliminary biocompatibility characterization of P(HEMA/IA/PEGDMA) hydrogels, done by the cytotoxicity assays using the HeLa cell line revails that the cell viability of all samples was the range of 97?100%, with no significant decrease in cell viability with the change of PEGDMA molecular weight and concentration. Swelling studies were conducted for all P(HEMA/IA/PEGDMA) samples in a physiological pH and temperature range and network parameters were determined. Swelling studies showed pH sensitive behaviour, typical for anionic hydrogels, and temperature dependent swelling. The effects of concentration of PEGDMA component on hydrogel swelling properties depend on the PEGDMA molecular weight. The samples with 550PEGDMA show different swelling capacities when 550PEGDMA content is changed, whereas for P(HEMA/IA/875PEGDMA) samples there was practically no difference in equilibrium degree of swelling, qe ,with varying 875PEGDMA content, which trend is the same as in the case of qe versus pH dependences. It was concluded that P(HEMA/IA/PEGDMA) hydrogels show good potential to be used as biomedical materials.

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