scholarly journals Preclinical amyloid‐PET SUVr in the precuneus and posterior cingulate associations with MoCA scores are driven by language domain subscores

2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Doaa Ali ◽  
Justin M Barber ◽  
Riham H El Khouli ◽  
Brian T. Gold ◽  
Jordan Harp ◽  
...  
Keyword(s):  
Amyloid Pet ◽  
Posterior Cingulate

scholarly journals Development and Clinical Validation of CT-Based Regional Centiloid Method for Amyloid PET

2021 ◽  
Author(s):  
Soo-Jong Kim ◽  
Hongki Ham ◽  
Yu Hyun Park ◽  
Yeong Sim Choe ◽  
Young Ju Kim ◽  
...  
Keyword(s):  
Validation Study ◽  
Neuropsychological Performance ◽  
Amyloid Pet ◽  
Clinical Validation ◽  
Target Region ◽  
Posterior Cingulate ◽  
Accessible Method ◽  
Mri Scans ◽  
Highly Correlated ◽  
Common Target

Abstract Background: We developed and validated CT-based regional Centiloid. A CT-based regional Centiloid was developed and validated in the present study. Methods: For development ofMRI-based or CT-based regional CLs,the cohort consist of 63 subjects (20 young controls (YC) and18 old controls (OC), and 25 Alzheimer’s disease dementia (ADD)).We used direct comparison of FMM-FBB CL (dcCL) method using MRI and CT images to define a common target region and six regional VOIs including the frontal, temporal, parietal, posterior cingulate, occipital and striatal regions. Global and regional dcCL scales were compared between MRI-based and CT-based methods. For clinical validation, cohortconsisted of 2,245subjects (627 in CN, 933 in MCI, and 685 in ADD). Results: Both MRI-based and CT-based dcCL scales showed that FMM and FBB were highly correlated with each other, globally and regionally (R2 = 0.96~0.99). Both FMM and FBB showed that CT-based regional dcCL scales were highly correlated with MRI-based regional dcCL scales (R2 = 0.97~0.99). Absolute differences in regional CL scales between CT-based and MRI-based methods seemed to be relatively insignificant (p>0.05). In our clinical validation study, the G(-)R(+) and G(+)Str(+) groups predict worse neuropsychological performance than the G(-)R(-) and the G(+)Str(-) groups (p< 0.05) respectively.Conclusions: Our findings suggested that it is feasible to convert FMM or FBB dcSUVR values into the dcCL scales regionally without additional MRI scans, which might in turn become a more easily accessible method for researchers and be applicable to a variety of different conditions.

Patterns of Distribution of 18F-THK5351 Positron Emission Tomography in Alzheimer’s Disease Continuum

2021 ◽  
pp. 1-12
Author(s):  
Takashi Nihashi ◽  
Keita Sakurai ◽  
Takashi Kato ◽  
Kaori Iwata ◽  
Yasuyuki Kimura ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Neuropsychological Assessment ◽  
Visual Analysis ◽  
Amyloid Pet ◽  
Cingulate Gyrus ◽  
Cognitively Normal ◽  
Posterior Cingulate ◽  
Posterior Cingulate Gyrus ◽  
Stage Progression ◽  
Normal Individuals

Background: Alzheimer’s disease (AD) is conceptualized as a biological continuum encompassing the preclinical (clinically asymptomatic but with evidence of AD pathology) and clinical (symptomatic) phases. Objective: Using 18F-THK5351 as a tracer that binds to both tau and MAO-B, we investigated the changes in 18F-THK5351 accumulation patterns in AD continuum individuals with positive amyloid PET consisting of cognitively normal individuals (CNp), amnestic mild cognitive impairment (aMCI), and AD and cognitively normal individuals (CNn) with negative amyloid PET. Methods: We studied 69 individuals (32 CNn, 11 CNp, 9 aMCI, and 17 AD) with structural magnetic resonance imaging, 11C-Pittsburgh compound-B (PIB) and 18F-THK5351 PET, and neuropsychological assessment. 18F-THK5351 accumulation was evaluated with visual analysis, voxel-based analysis and combined region of interest (ROI)-based analysis corresponding to Braak neurofibrillary tangle stage. Results: On visual analysis, 18F-THK5351 accumulation was increased with stage progression in the AD continuum. On voxel-based analysis, there was no statistical difference in 18F-THK5351 accumulation between CNp and CNn. However, a slight increase of the bilateral posterior cingulate gyrus in aMCI and definite increase of the bilateral parietal temporal association area and posterior cingulate gyrus/precuneus in AD were detected compared with CNn. On ROI-based analyses, 18F-THK5351 accumulation correlated positively with supratentorial 11C-PIB accumulation and negatively with the hippocampal volume and neuropsychological assessment. Conclusion: The AD continuum showed an increase in 18F-THK5351 with stage progression, suggesting that 18F-THK5351 has the potential to visualize the severity of tau deposition and neurodegeneration in accordance with the AD continuum.

Alzheimer-Demenz

2016 ◽  
Vol 35 (10) ◽  
pp. 673-678
Author(s):  
G. R. Fink ◽  
J. Kukolja
Keyword(s):  
Amyloid Pet ◽  
Alzheimer Demenz ◽  
Prävention Und Therapie

ZusammenfassungDemenzielle Erkrankungen spielen aufgrund des demografischen Wandels eine zunehmende Rolle in unserer Gesellschaft und somit auch im klinischen Alltag. Die Weiterentwicklung diagnostischer Methoden wie das Amyloid-PET und die Biomarkerbestimmung im Liquor hat eine Wende in der Klassifikation der Demenzen herbeigeführt. Es ist mittlerweile nicht nur möglich, die Alzheimer-Erkrankung als häufigste Ursache der Demenz schon in Frühstadien sicher zu erkennen. Auch einige klinisch atypische Demenzen zeigen die charakteristische Alzheimer-Pathologie und werden dementsprechend als Alzheimer-Varianten aufgefasst. Ein relevanter Anteil alzheimerähnlicher Demenzen beruht hingegen nicht auf einer alzheimerdefinierenden Amyloid-Pathologie.In diesem Übersichtsartikel werden die Folgen der modernen diagnostischen Methoden auf die Klassifikation der Demenzen, deren Prävention und Therapie diskutiert.

Bildgebende Verfahren in der Diagnostik von Demenzerkrankungen

2010 ◽  
Vol 29 (11) ◽  
pp. 758-760
Author(s):  
F Jessen
Keyword(s):  
Fdg Pet ◽  
Bildgebende Verfahren ◽  
Amyloid Pet ◽  
Neurodegenerative Erkrankungen ◽  
Zerebrale Bildgebung ◽  
Klinische Relevanz

ZusammenfassungDie zerebrale Bildgebung hat in der ätiologischen Diagnostik von Demenzerkrankungen die Funktion z. B. chirurgisch behandelbare Ursachen einer Demenz aufzudecken. Zusätzlich trägt sie zur Differenzialdiagnose von primären Demenzerkrankungen bei. Neurodegenerative Erkrankungen sind durch typische Atrophiemuster gekennzeichnet. Vaskuläre Läsionen können sensitiv mit der MRT erfasst werden. Zahlreiche neue MRT-Verfahren befinden sich in der klinischen Entwicklung. Als nuklearmedizinisches Verfahren ist insbesondere die 18F-Fluordesoxyglukose (FDG)-PET wertvoll. Die zukünftige klinische Relevanz von Amyloid-PET wird mit großer Wahrscheinlichkeit sehr hoch sein.

As a (white) matter of fact – Different white matter properties of beta-amyloid PET tracers

2020 ◽  
Author(s):  
M Rullmann ◽  
PL Flender ◽  
V Villemagne ◽  
O Sabri ◽  
H Barthel
Keyword(s):  
White Matter ◽  
Beta Amyloid ◽  
Amyloid Pet ◽  
Pet Tracers

Elucidating the risk factors for progression from amyloid-negative amnestic mild cognitive impairment to dementia

2020 ◽  
Vol 17 ◽  
Author(s):  
Hyung-Ji Kim ◽  
Jae-Hong Lee ◽  
E-nae Cheong ◽  
Sung-Eun Chung ◽  
Sungyang Jo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Amyloid Pet ◽  
Clinical Progression ◽  
Amnestic Mci

Background: Amyloid PET allows for the assessment of amyloid β status in the brain, distinguishing true Alzheimer’s disease from Alzheimer’s disease-mimicking conditions. Around 15–20% of patients with clinically probable Alzheimer’s disease have been found to have no significant Alzheimer’s pathology on amyloid PET. However, a limited number of studies had been conducted this subpopulation in terms of clinical progression. Objective: We investigated the risk factors that could affect the progression to dementia in patients with amyloid-negative amnestic mild cognitive impairment (MCI). Methods: This study was a single-institutional, retrospective cohort study of patients over the age of 50 with amyloidnegative amnestic MCI who visited the memory clinic of Asan Medical Center with a follow-up period of more than 36 months. All participants underwent brain magnetic resonance imaging (MRI), detailed neuropsychological testing, and fluorine-18[F18]-florbetaben amyloid PET. Results: During the follow-up period, 39 of 107 patients progressed to dementia from amnestic MCI. In comparison with the stationary group, the progressed group had a more severe impairment in verbal and visual episodic memory function and hippocampal atrophy, which showed an Alzheimer’s disease-like pattern despite the lack of evidence for significant Alzheimer’s disease pathology. Voxel-based morphometric MRI analysis revealed that the progressed group had a reduced gray matter volume in the bilateral cerebellar cortices, right temporal cortex, and bilateral insular cortices. Conclusion: Considering the lack of evidence of amyloid pathology, clinical progression of these subpopulation may be caused by other neuropathologies such as TDP-43, abnormal tau or alpha synuclein that lead to neurodegeneration independent of amyloid-driven pathway. Further prospective studies incorporating biomarkers of Alzheimer’s diseasemimicking dementia are warranted.

Serum Vitamin D and Cingulate Cortex Thickness in Older Adults: Quantitative MRI of the Brain

2019 ◽  
Vol 16 (11) ◽  
pp. 1063-1071 ◽  
Author(s):  
Gonzague Foucault ◽  
Guillaume T Duval ◽  
Romain Simon ◽  
Olivier Beauchet ◽  
Mickael Dinomais ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Brain Mri ◽  
Serum Vitamin ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Vitamin D Insufficiency ◽  
Anterior Cingulate ◽  
Posterior Cingulate ◽  
Significant Difference

Background: Vitamin D insufficiency is associated with brain changes, and cognitive and mobility declines in older adults. Method: Two hundred and fifteen Caucasian older community-dwellers (mean±SD, 72.1±5.5years; 40% female) received a blood test and brain MRI. The thickness of perigenual anterior cingulate cortex, midcingulate cortex and posterior cingulate cortex was measured using FreeSurfer from T1-weighted MR images. Age, gender, education, BMI, mean arterial pressure, comorbidities, use of vitamin D supplements or anti-vascular drugs, MMSE, GDS, IADL, serum calcium and vitamin B9 concentrations, creatinine clearance were used as covariables. Results: Participants with vitamin D insufficiency (n=80) had thinner total cingulate thickness than the others (24.6±1.9mm versus 25.3±1.4mm, P=0.001); a significant difference found for all 3 regions. Vitamin D insufficiency was cross-sectionally associated with a decreased total cingulate thickness (β=- 0.49, P=0.028). Serum 25OHD concentration correlated positively with the thickness of perigenual anterior (P=0.011), midcingulate (P=0.013) and posterior cingulate cortex (P=0.021). Conclusion: Vitamin D insufficiency was associated with thinner cingulate cortex in the studied sample of older adults. These findings provide insight into the pathophysiology of cognitive and mobility declines in older adults with vitamin D insufficiency.

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