DNA damage signatures in peripheral blood cells (PBMC) as biomarkers in prodromal Huntington's disease

2018 ◽  
Author(s):  
Imma Castaldo ◽  
Mariarosaria De Rosa ◽  
Antonella Romano ◽  
Candida Zuchegna ◽  
Ferdinando Squitieri ◽  
...  
Keyword(s):  
Dna Damage ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells

DNA Damage Signatures in Peripheral Blood Cells as Biomarkers in Prodromal Huntington's Disease

2018 ◽  
Author(s):  
Imma Castaldo ◽  
Mariarosaria De Rosa ◽  
Antonella Romano ◽  
Candida Zuchegna ◽  
Ferdinando Squitieri ◽  
...  
Keyword(s):  
Dna Damage ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells

scholarly journals RNA Sequencing of Human Peripheral Blood Cells Indicates Upregulation of Immune-Related Genes in Huntington's Disease

2020 ◽  
Vol 11 ◽  
Author(s):  
Miguel A. Andrade-Navarro ◽  
Katja Mühlenberg ◽  
Eike J. Spruth ◽  
Nancy Mah ◽  
Adrián González-López ◽  
...  
Keyword(s):  
Gene Expression ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Trinucleotide Repeat ◽  
Neurodegenerative Disorder ◽  
Gene Expression Signature ◽  
Interferon Response ◽  
Peripheral Blood Cells

Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a trinucleotide repeat expansion in the Huntingtin gene. As disease-modifying therapies for HD are being developed, peripheral blood cells may be used to indicate disease progression and to monitor treatment response. In order to investigate whether gene expression changes can be found in the blood of individuals with HD that distinguish them from healthy controls, we performed transcriptome analysis by next-generation sequencing (RNA-seq). We detected a gene expression signature consistent with dysregulation of immune-related functions and inflammatory response in peripheral blood from HD cases vs. controls, including induction of the interferon response genes, IFITM3, IFI6 and IRF7. Our results suggest that it is possible to detect gene expression changes in blood samples from individuals with HD, which may reflect the immune pathology associated with the disease.

Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington’s disease patients

2008 ◽  
Vol 374 (4) ◽  
pp. 599-603 ◽  
Author(s):  
Sandra Almeida ◽  
Ana Bela Sarmento-Ribeiro ◽  
Cristina Januário ◽  
A Cristina Rego ◽  
Catarina R Oliveira
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells ◽  
Mitochondrial Abnormalities

scholarly journals Mitochondrial Respiratory Function in Peripheral Blood Cells from Huntington's Disease Patients

2016 ◽  
Vol 3 (5) ◽  
pp. 472-482 ◽  
Author(s):  
Johannes K. Ehinger ◽  
Saori Morota ◽  
Magnus J. Hansson ◽  
Gesine Paul ◽  
Eskil Elmér
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Respiratory Function ◽  
Peripheral Blood Cells ◽  
Mitochondrial Respiratory

Aberrant A 2A receptor function in peripheral blood cells in Huntington's disease

2003 ◽  
Vol 17 (14) ◽  
pp. 1-16 ◽  
Author(s):  
Katia Varani ◽  
Maria P. Abbracchio ◽  
Milena Cannella ◽  
Giuliana Cislaghi ◽  
Patrizia Giallonardo ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Peripheral Blood Cells ◽  
Receptor Function

scholarly journals Paracoccidioidomycosis: no genetic damage in human peripheral blood cells of patients assessed by single-cell gel (comet) assay

2007 ◽  
Vol 40 (4) ◽  
pp. 476-478 ◽  
Author(s):  
Renata Aparecida Martinez Antunes Ribeiro-Vieira ◽  
Daniel Araki Ribeiro ◽  
Daisy Maria Favero Salvadori ◽  
Sílvio Alencar Marques
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Human Peripheral Blood ◽  
Paracoccidioides Brasiliensis ◽  
Peripheral Blood Cells ◽  
Genetic Damage ◽  
Systemic Fungal Infection ◽  
Dna Breakage

Paracoccidioidomycosis is a systemic fungal infection caused by Paracoccidioides brasiliensis. As infectious diseases can cause DNA damage, the authors aimed at analyzing DNA breakage in peripheral blood cells of patients with paracoccidioidomycosis by using the comet assay. The results suggested that paracoccidioidomycosis does not cause genotoxicity.

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