Combinatorial Chemistry: P. Seeberger Recognized / Medicinal Chemistry: R. Metternich on Board / Pharmaceutical Chemistry: G. Wess Directs GSF

2005 ◽  
Vol 44 (45) ◽  
pp. 7330-7330
Keyword(s):  
Combinatorial Chemistry ◽  
Medicinal Chemistry ◽  
Pharmaceutical Chemistry

Frontiers in Medicinal Chemistry 2015: Meet the Experts of MedChem near the Cradle of Medicinal and Pharmaceutical Chemistry

ChemMedChem ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. 1267-1271
Author(s):  
Christof Wegscheid-Gerlach ◽  
Hans-Dieter Gerber ◽  
Wibke E. Diederich
Keyword(s):  
Medicinal Chemistry ◽  
Pharmaceutical Chemistry

Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry

2012 ◽  
Vol 84 (9) ◽  
pp. 1837-1846 ◽  
Author(s):  
Vanderlan da Silva Bolzani ◽  
Marilia Valli ◽  
Marcos Pivatto ◽  
Cláudio Viegas
Keyword(s):  
Natural Products ◽  
Combinatorial Chemistry ◽  
Medicinal Chemistry ◽  
Therapeutic Agents ◽  
Molecular Structures ◽  
Biologically Active ◽  
Ache Inhibitors ◽  
Tropical Environments ◽  
Modern Drug ◽  
Brazilian Biodiversity

Natural products are the inspiration for many valuable therapeutic agents and attest to biodiversity being a rich source of new molecular structures. Their value as templates for medicinal chemistry remains undisputed, even after the growth of the combinatorial chemistry era. Tropical environments, such as Brazilian biomes, offer a particularly rich potential for biologically active compounds with unique structures and continue to contribute toward modern drug discovery. Our bioprospecting of plant species of the Cerrado and Atlantic Forest biomes has yielded promising bioactive secondary metabolites, and we describe some of these molecules and semisynthetic derivatives as potential acetylcholinesterase (AChE) inhibitors.

A Mini Review on Recent Advancements in the Therapeutic Potentials of Benzothiazoles

2019 ◽  
Vol 16 ◽  
Author(s):  
Rubina Bhutani ◽  
Garima Kapoor ◽  
Dharam Pal Pathak ◽  
Asif Husain ◽  
Ravi Kant ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Therapeutic Potential ◽  
Pharmaceutical Chemistry ◽  
Biological Potential ◽  
Heterocyclic Derivatives ◽  
Anti Inflammatory ◽  
Clinical Drugs

: Among the various fused heterocyclic rings, benzothiazole and its analogues have been explored broadly in search of newer therapeutic medicinal agents. The benzothiazole scaffold has been associated with huge biological potential like anticancer, antidiabetic, anti-inflammatory, anti-tubercular, antiviral, anti-convulsant etc. The occurrence of benzothiazole core in various compounds proves its value in the sphere of pharmaceutical chemistry. The connected research and developments in benzothiazole based chemistry become an active topic for medicinal scientists. A large number of benzothiazole and its heterocyclic derivatives are available in the market and used for the treatment of as clinical drugs have been extensively used in practice to treat diverse types of ailments with high therapeutic potential. This review presents the latest therapeutic developments of benzothiazole containing compounds in the medicinal chemistry.

scholarly journals Bio-instructive materials on-demand – combinatorial chemistry of peptoids, foldamers, and beyond

2021 ◽  
Author(s):  
Claudine Herlan ◽  
Dominik Feser ◽  
Ute Schepers ◽  
Stefan Bräse
Keyword(s):  
High Throughput ◽  
Combinatorial Chemistry ◽  
Medicinal Chemistry ◽  
Materials Science ◽  
Modular Design ◽  
Rapid Synthesis ◽  
On Demand ◽  
Compound Libraries ◽  
Large Compound

Combinatorial chemistry allows for the rapid synthesis of large compound libraries for high throughput screenings in biology, medicinal chemistry, or materials science. Especially compounds from a highly modular design are...

Bicyclic 6 + 6 Systems: Advances in the Chemistry of Heterocyclic Compounds Incorporated Pyrimido[1,2-a]Pyrimidine Skeleton

2020 ◽  
Vol 17 (6) ◽  
pp. 717-739 ◽  
Author(s):  
Mohamed Monier ◽  
Doaa Abdel-Latif ◽  
Ahmed El-Mekabaty ◽  
Khaled M. Elattar
Keyword(s):  
Heterocyclic Compounds ◽  
Medicinal Chemistry ◽  
Present Review ◽  
Pharmaceutical Chemistry ◽  
Significant Variable ◽  
Biological Applications ◽  
Carbon And Nitrogen ◽  
Biological Compounds ◽  
Synthetic Routes

The present review has highlighted the chemistry of pyrimido[1,2-a]pyrimidine compounds as one of the most important classes of heterocyclic systems. The main sections include: (1) The synthesis of pyrimido[1,2-a]pyrimidines, (2) reactivity of the substituents attached to the carbon and nitrogen atoms of the ring and (3) biological applications. A discussion demonstrated that the proposed mechanisms of unexpected synthetic routes were intended. The purpose of this review is to provide an overview of the chemistry of pyrimido[1,2-a]pyrimidines to date, in which the compounds should be widely applied in medicinal and pharmaceutical chemistry based on the significant, variable and potent biological results of pyrimidopyrimidine and pyridopyrimidine analogs. This survey will assist scientists in the organic and medicinal chemistry fields to design and develop procedures for the construction of new standard biological compounds.

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