Stimuli‐responsive hybrid microgels for controlled drug delivery: Sorafenib as a model drug

2020 ◽  
Vol 138 (14) ◽  
pp. 50147
Author(s):  
Tania Mariastella Caputo ◽  
Anna Aliberti ◽  
Angela Maria Cusano ◽  
Menotti Ruvo ◽  
Antonello Cutolo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Model Drug ◽  
Hybrid Microgels

A robust regenerated cellulose-based dual stimuli-responsive hydrogel as an intelligent switch for controlled drug delivery

2021 ◽  
Vol 176 ◽  
pp. 448-458
Author(s):  
Fuyu Song ◽  
Jingwei Gong ◽  
Yehan Tao ◽  
Yi Cheng ◽  
Jie Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Regenerated Cellulose ◽  
Stimuli Responsive

Novel Polyacrylamide/Polypyrrole Hydrogel for Electrically Controlled Release of Salicylic Acid

2019 ◽  
Vol 824 ◽  
pp. 176-181
Author(s):  
Walaiporn Prissanaroon-Ouajai ◽  
Natthika Koedsombat ◽  
Nuttapol Subbua
Keyword(s):  
Drug Delivery ◽  
Salicylic Acid ◽  
Free Radical ◽  
Conductive Polymer ◽  
Controlled Drug Delivery ◽  
Ammonium Persulfate ◽  
Applied Potential ◽  
Drug Release Rate ◽  
Cross Linker ◽  
Model Drug

Polyacrylamide/polypyrrole (PAM/PPy) hydrogel was developed for the application in controlled drug delivery. PAM/PPy hydrogel was synthesized via free-radical polymerization of acrylamide using ammonium persulfate (APS) as initiator in the dispersion of PPy nanoparticle. N,N’-methylenebisacrylamide (MBA) and N,N,N’,N’-tetra-methylenediamine (TEMED) were utilized as cross-linker and accelerator, respectively. Salicylic acid (SA) was selected as a model drug in this work. The effect of PPy contents on SA-loading and releasing performances was investigated. The more PPy content was incorporated, the greater SA-loading and releasing were found. This is attributed to the increasing pore size of the PAM hydrogel when PPy nanoparticles were incorporated. Drug releasing performance from the SA-loaded PAM/PPy hydrogel were controllable under the applied potential of 1.0 volt. The research exhibits the potential of using conductive polymer hydrogel to control the drug release rate at an optimal desired level.

Poly(ε-caprolactone) with pH and UCST responsiveness as a 5-fluorouracil carrier

2020 ◽  
Vol 11 (32) ◽  
pp. 5173-5180
Author(s):  
Shuang Zhu ◽  
Lianlei Wen ◽  
Yan Xiao ◽  
Meidong Lang
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Stimuli-responsive polymers with excellent biocompatibility and biodegradability are highly demanded as carriers for controlled drug delivery.

Stimuli-responsive poly(ionic liquid) nanoparticles for controlled drug delivery

2020 ◽  
Vol 8 (35) ◽  
pp. 7994-8001 ◽  
Author(s):  
Beibei Lu ◽  
Gaoxin Zhou ◽  
Fan Xiao ◽  
Qianjun He ◽  
Jiaheng Zhang
Keyword(s):  
Drug Delivery ◽  
Ionic Liquid ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Spherical Nanoparticles ◽  
High Drug ◽  
Good Ability ◽  
Poly Ionic Liquid ◽  
High Drug Loading

A novel poly(ionic liquid) (PIL)-based block copolymer, which can self-assemble into spherical nanoparticles, high drug loading content, and good ability to inhibit tumors. Therefore, this copolymer shows great potential for drug delivery. 

Utilization of L-serinyl derivate to preparing triple stimuli-responsive hydrogels for controlled drug delivery

2019 ◽  
Vol 26 (12) ◽  
Author(s):  
Chun Hui Luo ◽  
Xin Xin Sun ◽  
Feng Wang ◽  
Ning Wei ◽  
Fa Liang Luo
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Responsive Hydrogels

scholarly journals Morphology-tunable and pH-responsive supramolecular self-assemblies based on AB2-type host–guest-conjugated amphiphilic molecules for controlled drug delivery

2019 ◽  
Vol 15 ◽  
pp. 1925-1932 ◽  
Author(s):  
Yang Bai ◽  
Cai-ping Liu ◽  
Di Chen ◽  
Long-hai Zhuo ◽  
Huai-tian Bu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Controlled Drug Delivery ◽  
Transition Process ◽  
Hydrodynamic Diameter ◽  
Cancer Cell Proliferation ◽  
Acidic Ph ◽  
Stimuli Responsive ◽  
Amphiphilic Molecules ◽  
Acidic Conditions

Although stimuli-responsive supramolecular self-assemblies have been constructed, the controlled drug delivery induced by morphology transitions of these supramolecular self-assemblies on the basis of host–guest-conjugated monomers (HGCMs) are few reported. In this paper, the self-assembly behaviors of AB2-type HGCMs, e.g., β-cyclodextrin-benzimidazole2 (β-CD-BM2), were investigated at neutral and acidic pH conditions, respectively. Specifically, β-CD-BM2 first self-assembled into fan-shaped supramolecular self-assemblies with a hydrodynamic diameter of 163 nm at neutral pH, whereas they were further dissociated into spherical supramolecular self-assemblies with a size of 52 nm under acidic conditions. This morphology transition process was utilized to conduct a two-stage DOX delivery under neutral and acidic pH. Basic cell experiments demonstrated that the drug-loaded β-CD-BM2-based supramolecular self-assemblies with varied morphology could inhibit cancer cell proliferation, indicating their potential application in the field of drug delivery.

Progress of Stimuli-Responsive Nanoscale Metal Organic Frameworks as Controlled Drug Delivery Systems

2020 ◽  
Vol 17 ◽  
Author(s):  
Ailing Feng ◽  
Yanni Wang ◽  
Jinzi Ding ◽  
Rong Xu ◽  
Xiaodong Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Direct Assembly ◽  
Metal Organic ◽  
Organic Framework

Background: Development of controlled drug delivery systems can improve the pharmacokinetic characteristics of drug molecules in the human body, thereby significantly improving the utilization rate of drugs and reducing toxicity and side effects caused by high concentrations of drugs, which can occur when delivery is not controlled. Metal organic frameworks are a new class of very promising crystalline microporous materials, especially when the size is reduced to the nanometer range. Metal organic frameworks exhibit large specific surface areas, tunable compositions, and easy functionalization. In recent years, increasing number of studies have reported the remarkable advances in multifunctional nanoscale metal organic frameworks in drug delivery. Objective: Review the latest research involving advances in stimuli-responsive nanoscale metal organic frameworks as drug delivery systems in controlled-release drugs. Discussion: We first introduce the two main strategies associated with nanoscale metal organic frameworks used in drug loading: direct assembly and post-encapsulation. We next focus on the latest discoveries of nanoscale metal organic framework-based stimulus response systems for drug delivery, including pH, magnetics, light, ion, temperature, and other stimuli, as well as multiple stimulus-responsive drug delivery systems. Finally, we discuss the challenges and future development directions of nanoscale metal organic framework-based controlled drug release.

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