Novel Polyacrylamide/Polypyrrole Hydrogel for Electrically Controlled Release of Salicylic Acid

2019 ◽  
Vol 824 ◽  
pp. 176-181
Author(s):  
Walaiporn Prissanaroon-Ouajai ◽  
Natthika Koedsombat ◽  
Nuttapol Subbua
Keyword(s):  
Drug Delivery ◽  
Salicylic Acid ◽  
Free Radical ◽  
Conductive Polymer ◽  
Controlled Drug Delivery ◽  
Ammonium Persulfate ◽  
Applied Potential ◽  
Drug Release Rate ◽  
Cross Linker ◽  
Model Drug

Polyacrylamide/polypyrrole (PAM/PPy) hydrogel was developed for the application in controlled drug delivery. PAM/PPy hydrogel was synthesized via free-radical polymerization of acrylamide using ammonium persulfate (APS) as initiator in the dispersion of PPy nanoparticle. N,N’-methylenebisacrylamide (MBA) and N,N,N’,N’-tetra-methylenediamine (TEMED) were utilized as cross-linker and accelerator, respectively. Salicylic acid (SA) was selected as a model drug in this work. The effect of PPy contents on SA-loading and releasing performances was investigated. The more PPy content was incorporated, the greater SA-loading and releasing were found. This is attributed to the increasing pore size of the PAM hydrogel when PPy nanoparticles were incorporated. Drug releasing performance from the SA-loaded PAM/PPy hydrogel were controllable under the applied potential of 1.0 volt. The research exhibits the potential of using conductive polymer hydrogel to control the drug release rate at an optimal desired level.

Preparation and Characterization of Biopolymeric Nanoparticles as Drug Delivery Vehicles

2017 ◽  
pp. 225-246
Author(s):  
Sai S. Sagiri ◽  
Suraj K. Nayak ◽  
S. Lakshmi ◽  
Kunal Pal
Keyword(s):  
Drug Delivery ◽  
Salicylic Acid ◽  
Drug Release ◽  
Chitosan Nanoparticles ◽  
Xrd Analysis ◽  
Gelatin Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Model Drug ◽  
Bioactive Agents

In recent years, the use of biopolymeric nanoparticles as vehicles for drug delivery has increased exponentially. In the present study, chitosan and gelatin nanoparticles were prepared by ionic gelation and desolvation methods, respectively. Salicylic acid was used as the model drug. The nanoparticles were characterized using SEM, XRD analysis and FTIR spectrophotometric studies. In vitro drug release experiments were carried out to understand the mechanism of drug release. SEM micrographs showed the formation of spherical nanoparticles. XRD studies indicated a higher crystalline nature of the chitosan nanoparticles as compared to the gelatin nanoparticles. FTIR studies indicated the presence of salicylic acid within the drug- loaded nanoparticles. Drug release studies indicated that the developed nanoparticles may be used as carriers for various bioactive agents.

scholarly journals Design and Characterization of a Silk-Fibroin-Based Drug Delivery Platform Using Naproxen as a Model Drug

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Tatyana Dyakonov ◽  
Chue Hue Yang ◽  
Derek Bush ◽  
Saujanya Gosangari ◽  
Shingai Majuru ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silk Fibroin ◽  
Conformational Changes ◽  
Oral Drug Delivery ◽  
Controlled Drug Delivery ◽  
Release Profile ◽  
Oral Drug ◽  
Delivery Platform ◽  
Model Drug

The objective of this proof-of-concept study was to develop a platform for controlled drug delivery based on silk fibroin (SF) and to explore the feasibility of using SF in oral drug delivery. The SF-containing matrixes were prepared via spray-drying and film casting, and the release profile of the model drug naproxen sodium was evaluated. Attenuated total reflectance Fourier transform infrared spectroscopy (FTIR) has been used to observe conformational changes in SF- and drug-containing compositions. SF-based films, spray-dried microparticles, and matrixes loaded with naproxen were prepared. Both FTIR spectra and in vitro dissolution data demonstrated that SF β-sheet conformation regulates the release profile of naproxen. The controlled release characteristics of the SF-containing compositions were evaluated as a function of SF concentration, temperature, and exposure to dehydrating solvents. The results suggest that SF may be an attractive polymer for use in controlled drug delivery systems.

Preparation and Characterization of Biopolymeric Nanoparticles as Drug Delivery Vehicles

2021 ◽  
pp. 1659-1680
Author(s):  
Sai S. Sagiri ◽  
Suraj K. Nayak ◽  
S. Lakshmi ◽  
Kunal Pal
Keyword(s):  
Drug Delivery ◽  
Salicylic Acid ◽  
Drug Release ◽  
Chitosan Nanoparticles ◽  
Xrd Analysis ◽  
Gelatin Nanoparticles ◽  
Drug Delivery Vehicles ◽  
Model Drug ◽  
Bioactive Agents

In recent years, the use of biopolymeric nanoparticles as vehicles for drug delivery has increased exponentially. In the present study, chitosan and gelatin nanoparticles were prepared by ionic gelation and desolvation methods, respectively. Salicylic acid was used as the model drug. The nanoparticles were characterized using SEM, XRD analysis and FTIR spectrophotometric studies. In vitro drug release experiments were carried out to understand the mechanism of drug release. SEM micrographs showed the formation of spherical nanoparticles. XRD studies indicated a higher crystalline nature of the chitosan nanoparticles as compared to the gelatin nanoparticles. FTIR studies indicated the presence of salicylic acid within the drug- loaded nanoparticles. Drug release studies indicated that the developed nanoparticles may be used as carriers for various bioactive agents.

Controlled Drug Delivery System Based on Magnetic Hollow Spheres/Polyelectrolyte Multilayer Core–Shell Structure

2006 ◽  
Vol 6 (9) ◽  
pp. 3210-3214 ◽  
Author(s):  
YanQi Zhang ◽  
LinLin Li ◽  
Fangqiong Tang ◽  
Jun Ren
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hollow Spheres ◽  
Hollow Structure ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Layer By Layer ◽  
Controlled Drug Delivery System ◽  
Model Drug

A novel controlled drug delivery system was fabricated by coating chitosan/PAA multilayer onto magnetic hollow spheres via a "Layer-by-Layer" (LBL) assembly approach. Cefradine was used as a model drug to evaluate the drug release characteristics of this core–shell hollow structure and the results show that it exhibits a sustained release of the drug and the release rate can be regulated by the pH environment of release medium. It is believed that this core–shell hollow structure, which combines the advantage of controlled delivery as well as magnetic targeting, has commendable potential in drug delivery therapeutics.

Physically cross-linked pH-responsive chitosan-based hydrogels with enhanced mechanical performance for controlled drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (107) ◽  
pp. 106035-106045 ◽  
Author(s):  
YuJu Che ◽  
Dongping Li ◽  
Yulong Liu ◽  
Qinglin Ma ◽  
Yebang Tan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Free Radical ◽  
Acrylic Acid ◽  
Radical Polymerization ◽  
Mechanical Performance ◽  
Free Radical Polymerization ◽  
Controlled Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate

A novel physically cross-linked pH-responsive hydrogel with enhanced mechanical performance was prepared from chitosan, acrylic acid and (2-dimethylamino) ethyl methacrylate via in situ free radical polymerization for controlled drug delivery.

Stimuli‐responsive hybrid microgels for controlled drug delivery: Sorafenib as a model drug

2020 ◽  
Vol 138 (14) ◽  
pp. 50147
Author(s):  
Tania Mariastella Caputo ◽  
Anna Aliberti ◽  
Angela Maria Cusano ◽  
Menotti Ruvo ◽  
Antonello Cutolo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Stimuli Responsive ◽  
Model Drug ◽  
Hybrid Microgels

A pH-Sensitive Poly (2-(Acryloyloxy) Propanoic Acid) Hydrogel and its Drug Release Behaviors

2012 ◽  
Vol 455-456 ◽  
pp. 901-906
Author(s):  
Kui Lin Deng ◽  
Chun Yuan Huang ◽  
Xiao Bo Ren ◽  
Yu Bo Gou ◽  
Hai Bin Zhong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Salicylic Acid ◽  
Drug Release ◽  
Phosphate Buffer Solution ◽  
Ph Sensitive ◽  
Propanoic Acid ◽  
Buffer Solution ◽  
H Nmr ◽  
Model Drug

A novel pH-sensitive poly (2-(acryloyloxy) propanoic acid) hydrogel (PAPA) synthesized from lactic acid by radical polymerization has been investigated in this work. The structure of prepared monomer2-(acryloyloxy) propanoic acid) (APA) has been characterized by FTIR and1H-NMR measurements. PAPA hydrogel demonstrated an obvious pH sensitivity in its swelling in the range of 4-7 pH of phosphate buffer solution (PBS). The rapid response of the hydrogel makes it suitable for drug delivery application. Here, salicylic acid (SA) selected as a model drug, thein-vitrodrug release as a function of pH and temperature was studied systematically. The cumulative release of salicylic acid reached up to 86.6% in pH=7.4 PBS at 37.0°C within 550min. In pH=2.1 PBS, however, only 26.6% drug was released from the pH-sensitive PAPA on the same conditions.

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