A quantitative study of the activity of the reticulo-endothelial structures in bone marrow in normal and ischemic limbs as indicated by India ink and titanium dioxide

1939 ◽  
Vol 74 (2) ◽  
pp. 231-255 ◽  
Author(s):  
Charles Huggins
Keyword(s):  
Bone Marrow ◽  
Titanium Dioxide ◽  
Quantitative Study ◽  
India Ink

scholarly journals Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells

2021 ◽  
Vol 22 (2) ◽  
pp. 772
Author(s):  
Javier Conde ◽  
Marlene Schwarzfischer ◽  
Egle Katkeviciute ◽  
Janine Häfliger ◽  
Anna Niechcial ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Titanium Dioxide ◽  
Genetic Risk ◽  
Intestinal Inflammation ◽  
Sodium Sulphate ◽  
Food Additive ◽  
Wild Type ◽  
Dextran Sodium Sulphate ◽  
Risk Gene ◽  
The Impact

Environmental and genetic factors have been demonstrated to contribute to the development of inflammatory bowel disease (IBD). Recent studies suggested that the food additive; titanium dioxide (TiO2) might play a causative role in the disease. Therefore, in the present study we aimed to explore the interaction between the food additive TiO2 and the well-characterized IBD risk gene protein tyrosine phosphatase non-receptor type 2 (Ptpn2) and their role in the development of intestinal inflammation. Dextran sodium sulphate (DSS)-induced acute colitis was performed in mice lacking the expression of Ptpn2 in myeloid cells (Ptpn2LysMCre) or their wild type littermates (Ptpn2fl/fl) and exposed to the microparticle TiO2. The impact of Ptpn2 on TiO2 signalling pathways and TiO2-induced IL-1β and IL-10 levels were studied using bone marrow-derived macrophages (BMDMs). Ptpn2LysMCre exposed to TiO2 exhibited more severe intestinal inflammation than their wild type counterparts. This effect was likely due to the impact of TiO2 on the differentiation of intestinal macrophages, suppressing the number of anti-inflammatory macrophages in Ptpn2 deficient mice. Moreover, we also found that TiO2 was able to induce the secretion of IL-1β via mitogen-activated proteins kinases (MAPKs) and to repress the expression of IL-10 in bone marrow-derived macrophages via MAPK-independent pathways. This is the first evidence of the cooperation between the genetic risk factor Ptpn2 and the environmental factor TiO2 in the regulation of intestinal inflammation. The results presented here suggest that the ingestion of certain industrial compounds should be taken into account, especially in individuals with increased genetic risk

scholarly journals Intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study

2006 ◽  
Vol 76 (5) ◽  
pp. 392-398 ◽  
Author(s):  
Achille Pich ◽  
Flavio Fraire ◽  
Alessandro Fornari ◽  
Laura Davico Bonino ◽  
Laura Godio ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Quantitative Study ◽  
Marginal Zone ◽  
Marginal Zone Lymphoma ◽  
Bone Marrow Infiltration ◽  
Splenic Marginal Zone Lymphoma

scholarly journals Titanium pigment in tissues of drug addicts: report of 5 necropsied cases

2004 ◽  
Vol 59 (2) ◽  
pp. 86-88 ◽  
Author(s):  
Marcus Aurelho de Lima ◽  
Vitorino Modesto dos Santos ◽  
Samia Demachki ◽  
Javier Lazo
Keyword(s):  
Bone Marrow ◽  
Titanium Dioxide ◽  
Forensic Pathology ◽  
Drug Addicts ◽  
Potential Contribution ◽  
Tissue Samples ◽  
Polarized Microscopy ◽  
Body Tissues ◽  
Pathologic Findings ◽  
Morphologic Data

The aim of this report is to describe the anatomic-pathologic findings from necropsies of 5 drug addicts with titanium pigment in several organs after chronic intravenous injection of crushed propoxyphene hydrochloride tablets. Samples from liver, spleen, lungs, lymph nodes, and bone marrow were obtained, and after being grossly studied, they were submitted to evaluation using common light and polarized microscopy. In all 5 cases, a pigment with characteristics of titanium dioxide was found within tissue samples of the organs studied. Our findings suggest that research concerning titanium pigment within body tissues should be enhanced, considering the potential contribution of this morphologic data to forensic pathology.

Eosinophil populations in blood and bone marrow of normal guinea pigs

1960 ◽  
Vol 198 (6) ◽  
pp. 1171-1173 ◽  
Author(s):  
George Hudson
Keyword(s):  
Bone Marrow ◽  
Body Weight ◽  
Quantitative Study ◽  
Guinea Pigs ◽  
Large Population ◽  
Band Form ◽  
Eosinophil Granulocytes

A quantitative study of eosinophil granulocytes of bone marrow and blood was carried out in 10 normal guinea pigs of approximately 400 gm body weight. Relative to the population of eosinophils in the blood, there was a very large population of eosinophil granulocytes in the bone marrow. About three-quarters of the marrow eosinophils were of the segmented or band form. These appeared to constitute a relatively large and readily available reserve of cells.

scholarly journals Early Infection in Bone Marrow Transplantation: Quantitative Study of Clinical Factors That Affect Risk

1999 ◽  
Vol 28 (2) ◽  
pp. 256-266 ◽  
Author(s):  
Eric A. Engels ◽  
Charles A. Ellis ◽  
Stacey E. Supran ◽  
Christopher H. Schmid ◽  
Michael Barza ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Quantitative Study ◽  
Marrow Transplantation ◽  
Early Infection ◽  
Clinical Factors
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