Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes

Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a cytokine involved in various biological phenomena including ontogeny, morphogenesis, carcinogenesis, and maintenance of stem cells. The Wnt signaling pathway can be classified into two main pathways: canonical and non-canonical. Of these, the canonical Wnt signaling pathway promotes osteogenesis. Sclerostin produced by osteocytes is an inhibitor of this pathway, thereby inhibiting osteogenesis. Recently, osteoporosis treatment using an anti-sclerostin therapy has been introduced. In this review, the basics of Wnt signaling, its role in bone metabolism and its involvement in skeletal disorders have been covered. Furthermore, the clinical significance and future scopes of Wnt signaling in osteoporosis, osteoarthritis, rheumatoid arthritis and neoplasia are discussed.

Download Full-text

TLR dependent XBP-1 activation induces an autocrine loop in rheumatoid arthritis synoviocytes

Journal of Autoimmunity ◽

10.1016/j.jaut.2013.11.002 ◽

2014 ◽

Vol 50 ◽

pp. 59-66 ◽

Cited By ~ 38

Author(s):

Sinisa Savic ◽

Lylia Ouboussad ◽

Laura J. Dickie ◽

Janina Geiler ◽

Chi Wong ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Autocrine Loop ◽

Rheumatoid Arthritis Synoviocytes

Download Full-text

MiR-495 inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis rats via Wnt signaling pathway

Panminerva Medica ◽

10.23736/s0031-0808.20.03855-0 ◽

2020 ◽

Author(s):

Jiewei Wang ◽

Hongmei Yang ◽

Hong Ma ◽

Qingtao Han ◽

Qingyan Li ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Wnt Signaling ◽

Signaling Pathway ◽

Wnt Signaling Pathway

Download Full-text

A1.19 Zinc and cadmium homeostasis is altered in rheumatoid arthritis synoviocytes

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2013-205124.18 ◽

2014 ◽

Vol 73 (Suppl 1) ◽

pp. A8.1-A8

Author(s):

Paola Bonaventura ◽

Fabien Lavocat ◽

Giulia Benedetti ◽

Aline Lambroux ◽

Francis Albarede ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Rheumatoid Arthritis Synoviocytes

Download Full-text

Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes

Cytokine ◽

10.1016/j.cyto.2005.06.002 ◽

2005 ◽

Vol 31 (5) ◽

pp. 335-348 ◽

Cited By ~ 18

Author(s):

P VERGNESALLE ◽

D LEGER ◽

P BERTIN ◽

R TREVES ◽

J BENEYTOUT ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Active Metabolite ◽

Signalling Pathway ◽

Human Rheumatoid Arthritis ◽

Cytokine Release ◽

Mapk Signalling Pathway ◽

Mapk Signalling ◽

Rheumatoid Arthritis Synoviocytes

Download Full-text

Chemical variability of Rhododendron tomentosum (Ledum palustre) essential oils and their pro-apoptotic effect on lymphocytes and rheumatoid arthritis synoviocytes

Fitoterapia ◽

10.1016/j.fitote.2019.104402 ◽

2019 ◽

Vol 139 ◽

pp. 104402 ◽

Cited By ~ 2

Author(s):

Anna Jesionek ◽

Adam Kokotkiewicz ◽

Anna Mikosik-Roczynska ◽

Klaudia Ciesielska-Figlon ◽

Piotr Luczkiewicz ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Essential Oils ◽

Ledum Palustre ◽

Chemical Variability ◽

Apoptotic Effect ◽

Rheumatoid Arthritis Synoviocytes ◽

Rhododendron Tomentosum

Download Full-text

Lipid Peroxidation-Mediated Inflammation Promotes Cell Apoptosis through Activation of NF-κB Pathway in Rheumatoid Arthritis Synovial Cells

Mediators of Inflammation ◽

10.1155/2015/460310 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 27

Author(s):

Geng Yin ◽

Ying Wang ◽

Xiao-min Cen ◽

Min Yang ◽

Yan Liang ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Cell Apoptosis ◽

Inflammatory Responses ◽

Synovial Fibroblasts ◽

Systemic Autoimmune Disease ◽

New Strategy ◽

Significant Clinical Improvement ◽

Rheumatoid Arthritis Synoviocytes ◽

Initiation Of Therapy

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints. The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines. However, some of the targeted therapies for inflammation reactions do not display significant clinical improvement after initiation of therapy. Thus, the relationship between inflammatory responses and RA therapy is still incompletely understood. In the present study, we proposed to determine whether enhanced inflammations may lead to cell apoptosis in rheumatoid arthritis synoviocytes. Our results indicated that products of lipid peroxidations, 4-HNE, may induce synovial intrinsic inflammations by activating NF-κB pathways and it may lead to cell apoptosis. Pharmacological inhibition of NF-κB activation may reduce the 4-HNE mediated inflammation responses and subsequent cell apoptosis. Our results may help to clarify the role of inflammations on RA development and imply that blocking NF-κB activation may be partly beneficial for human RA therapy. These findings might provide a mechanism-based rationale for developing new strategy to RA clinical therapy.

Download Full-text