IRE1α‐mediated monounsaturated fatty acid synthesis drives B cell differentiation and lupus‐like autoimmune disease

2021 ◽  
Author(s):  
Yana Zhang ◽  
Ming Gui ◽  
Yajun Wang ◽  
Nikita Mani ◽  
Shuvam Chaudhuri ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cell Differentiation ◽  
Autoimmune Disease ◽  
B Cell ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Monounsaturated Fatty Acid ◽  
B Cell Differentiation

scholarly journals EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Jiqin Zhang ◽  
Fei Song ◽  
Xiaojing Zhao ◽  
Hua Jiang ◽  
Xiuqi Wu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Monounsaturated Fatty Acid

scholarly journals UCP1 deficiency increases adipose tissue monounsaturated fatty acid synthesis and trafficking to the liver

2017 ◽  
Vol 59 (2) ◽  
pp. 224-236 ◽  
Author(s):  
Laura M. Bond ◽  
James M. Ntambi
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Monounsaturated Fatty Acid

scholarly journals Increasing jojoba-like wax ester production in Saccharomyces cerevisiae by enhancing very long-chain, monounsaturated fatty acid synthesis

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Leonie Wenning ◽  
Christer S. Ejsing ◽  
Florian David ◽  
Richard R. Sprenger ◽  
Jens Nielsen ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Monounsaturated Fatty Acid ◽  
Wax Ester ◽  
Long Chain

scholarly journals Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity

2021 ◽  
Vol 12 ◽  
Author(s):  
Azusa Kobayashi ◽  
Ayaka Ito ◽  
Ibuki Shirakawa ◽  
Atsushi Tamura ◽  
Susumu Tomono ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Cell Differentiation ◽  
Eicosapentaenoic Acid ◽  
B Cell ◽  
Acid Composition ◽  
Plasma Cells ◽  
Membrane Dynamics ◽  
B Cell Differentiation ◽  
Autoantibody Production

Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with the development of autoimmune diseases. However, the mechanism by which fatty acid composition influences autoimmune responses remains unclear. To determine whether the fatty acid composition of diet modulates leukocyte function and the development of systemic lupus erythematosus, we examined the effect of eicosapentaenoic acid (EPA) on the pathology of lupus in drug-induced and spontaneous mouse models. We found that dietary EPA supplementation ameliorated representative lupus manifestations, including autoantibody production and immunocomplex deposition in the kidneys. A combination of lipidomic and membrane dynamics analyses revealed that EPA remodels the lipid composition and fluidity of B cell membranes, thereby preventing B cell differentiation into autoantibody-producing plasma cells. These results highlight a previously unrecognized mechanism by which fatty acid composition affects B cell differentiation into autoantibody-producing plasma cells during autoimmunity, and imply that EPA supplementation may be beneficial for therapy of lupus.

scholarly journals Role of Hepatic Monounsaturated Fatty Acid Synthesis in Metabolic Regulation

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Maggie Strable ◽  
Matthew Flowers ◽  
Xueqing Liu ◽  
James M Ntambi
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Metabolic Regulation ◽  
Acid Synthesis ◽  
Monounsaturated Fatty Acid

scholarly journals Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease

2005 ◽  
Vol 17 (9) ◽  
pp. 1179-1191 ◽  
Author(s):  
Duncheng Wang ◽  
Shinu A. John ◽  
James L. Clements ◽  
Dean H. Percy ◽  
Kevin P. Barton ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Autoimmune Disease ◽  
B Cell ◽  
B Cell Differentiation

SREBPs: Activators of cholesterol and monounsaturated fatty acid synthesis

1999 ◽  
Vol 144 ◽  
pp. 10
Author(s):  
J.D. Horton ◽  
H. Shimano ◽  
I. Shimomura ◽  
R.E. Hammer ◽  
M.S. Brown ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Monounsaturated Fatty Acid
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