Time trend in incidence of malignant neoplasms of the central nervous system in relation to mobile phone use among young people in Japan

2016 ◽  
Vol 37 (5) ◽  
pp. 282-289 ◽  
Author(s):  
Yasuto Sato ◽  
Kosuke Kiyohara ◽  
Noriko Kojimahara ◽  
Naohito Yamaguchi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Young People ◽  
Mobile Phone ◽  
Time Trend ◽  
Malignant Neoplasms ◽  
Mobile Phone Use ◽  
The Central Nervous System

Immune and Infectious Diseases

2018 ◽  
pp. 430-470
Author(s):  
Andrea C. Adams
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Young People ◽  
Connective Tissue ◽  
Infectious Diseases ◽  
Temporal Profile ◽  
Immune Mediated ◽  
The Central Nervous System ◽  
The Common

Many immune-mediated diseases and infections affect the central and peripheral nervous systems. The common feature that characterizes both immune-mediated diseases and infections is a subacute temporal profile. Immune-mediated disease can affect only the nervous system or involve the nervous system as part of a systemic illness, as in vasculitis and connective tissue disease. Multiple sclerosis (MS), the most common disabling neurologic illness of young people, is the prototypical immune-mediated disease of the central nervous system (CNS).

MALIGNANT TUMORS OF THE CENTRAL NERVOUS SYSTEM IN THE CHILDREN OF THE NUCLEAR PRODUCTION WORKERS

2018 ◽  
Vol 64 (6) ◽  
pp. 745-751
Author(s):  
Svetlana Sosnina ◽  
Irina Martinenko ◽  
Mikhail Sokolnikov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gamma Irradiation ◽  
Malignant Tumors ◽  
Morphological Type ◽  
Incidence Rates ◽  
Malignant Neoplasms ◽  
Average Value ◽  
Mayak Production Association ◽  
The Central Nervous System

The incidence of malignant neoplasms of the brain and the spinal medulla in children of Mayak Production Association workers who exposed preconceptive gamma irradiation was analyzed in the paper. The retrospective analysis was carried out within the cohort of children under the age of 15 born in 1948-2013 which includes 72316 people born and have been living in Ozersk, located near the nuclear plant. Overall 13 cases of malignant neoplasms of the central nervous system were registered among descendants of persons exposed in the workplace. The average value of the total dose of preconceptive gamma irradiation among mothers reached 251.95 mGy, among fathers - 211.42 mGy. The most frequent localization of malignant process was cerebellum, the most frequent morphological type of tumor was astrocytoma. Comparative analysis of morbidity was carried out by the method of indirect standardization, herewith regional and national age-sex incidence rates were applied. There was no significant excess of the incidence of malignant neoplasms of the central nervous system among children of nuclear workers. Standardized incidence ratio in comparison with the national statistics for children under 15 generally amounted in 1.04 in boys (95% confidence interval 0.5-1.87), in girls - 0.58 (0.18-1.35); in comparison with the regional statistics: in boys - 1.16 (0.56-2.09), in girls - 0.36 (0.11-0.85).

Primitive neuroectodermal tumors of the central nervous system in children

1978 ◽  
Vol 48 (5) ◽  
pp. 741-746 ◽  
Author(s):  
Edward J. Kosnik ◽  
Carl P. Boesel ◽  
Janet Bay ◽  
Martin P. Sayers
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Neoplasms ◽  
Duration Of Symptoms ◽  
Content Type ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
The Central Nervous System ◽  
Progressive Course ◽  
Fine Print

✓ A series of 18 primitive neuroectodermal tumors in children (15 cerebral and three spinal) is reported. These are highly malignant neoplasms, both histologically and clinically. They are rapidly growing tumors, with a brief duration of symptoms and a rapidly progressive course. Forty percent of the patients were alive at 6 months, only 10% at 1 year, and all patients had died within 2 years following diagnosis.

scholarly journals Experience in the Rehabilitation of Patients After Removal of Malignant Neoplasms of the Central Nervous System: A Clinical Case

2021 ◽  
Vol 3 (1) ◽  
pp. 131-138
Author(s):  
Marina V. Stern ◽  
Elena V. Polkovnikova ◽  
Marina V. Petrova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Case ◽  
Malignant Neoplasm ◽  
Malignant Neoplasms ◽  
System A ◽  
Clinical Center ◽  
Urgent Task ◽  
The Central Nervous System ◽  
Active Rehabilitation

Background. Early rehabilitation of patients after removal of neoplasms is an urgent task of modern rehabilitation. Clinical case description. This clinical example describes an example of rehabilitation and dynamics of recovery in a patient after removal of glioblastoma. After removal of a malignant neoplasm of the central nervous system, the patient underwent a course of rehabilitation measures within the framework of hospitalization at the Federal Research Center for Clinical Center of the Russian Federation. Conclusion. Patients after removal of malignant neoplasms are shown early active rehabilitation in order to compensate for neurological and mental deficits after removal of neoplasms of the central nervous system.

scholarly journals Vitamin D and multiple sclerosis

2021 ◽  
Vol 23 (2) ◽  
pp. 165-169
Author(s):  
Viktoriia R. Cheredanova ◽  
◽  
Ivan A. Chabin ◽  
Raisa Ts. Bembeeva ◽  
◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Vitamin D ◽  
Nervous System ◽  
Autoimmune Disease ◽  
Young People ◽  
Clinical Course ◽  
Current Data ◽  
Vitamin D Levels ◽  
The Central Nervous System

Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system and is a major cause of disability in able-bodied young people. Recently, the question of the effect of vitamin D on the risk of occurrence and clinical course of MS has been widely discussed. The review presents pathogenesis of this disease and estimated mechanisms of the effect of cholecalciferol on it, current data on the effect of vitamin D levels on the risk of MS, the course and outcome of this disease.

scholarly journals Some modern methods of diagnosis and pathogenetic therapy of multiple sclerosis

2002 ◽  
Vol XXXIV (1-2) ◽  
pp. 65-72
Author(s):  
I. D. Stolyarov ◽  
G. N. Bisaga ◽  
M. V. Votintseva ◽  
A. G. Ilves ◽  
I. G. Nikiforova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Chronic Disease ◽  
Young People ◽  
Neurological Disease ◽  
Genetically Engineered ◽  
Modern Methods ◽  
Pathogenetic Therapy ◽  
The Central Nervous System

Multiple sclerosis (MS) is a severe chronic disease of the central nervous system (CNS) that affects young people and quickly leads to disability. Until now, the pathogenesis of this neurological disease, which is the most expensive for society, has not been fully elucidated, and the drugs used to treat MS patients can only slightly suspend but not interrupt the development of the disease. At the same time, the possibilities of diagnosing and treating MS have expanded due to the active study and implementation of neuroimaging, neuroimmunological and neurophysiological methods, and the use of new immunocorrecting genetically engineered drugs.

scholarly journals Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Andrey Korshunov ◽  
Konstantin Okonechnikov ◽  
Felix Schmitt-Hoffner ◽  
Marina Ryzhova ◽  
Felix Sahm ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Molecular Analysis ◽  
Malignant Neoplasms ◽  
Wild Type ◽  
Diagnostic Challenge ◽  
Microscopic Appearance ◽  
Primitive Neuroectodermal Tumors ◽  
Neuroectodermal Tumors ◽  
The Central Nervous System

AbstractPrimitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly malignant neoplasms posing diagnostic challenge due to a lack of defining molecular markers. CNS neuroblastoma with forkhead box R2 (FOXR2) activation (CNS_NBL) emerged as a distinct pediatric brain tumor entity from a pool previously diagnosed as primitive neuroectodermal tumors of the central nervous system (CNS-PNETs). Current standard of identifying CNS_NBL relies on molecular analysis. We set out to establish immunohistochemical markers allowing safely distinguishing CNS_NBL from morphological mimics. To this aim we analyzed a series of 84 brain tumors institutionally diagnosed as CNS-PNET. As expected, epigenetic analysis revealed different methylation groups corresponding to the (1) CNS-NBL (24%), (2) glioblastoma IDH wild-type subclass H3.3 G34 (26%), (3) glioblastoma IDH wild-type subclass MYCN (21%) and (4) ependymoma with RELA_C11orf95 fusion (29%) entities. Transcriptome analysis of this series revealed a set of differentially expressed genes distinguishing CNS_NBL from its mimics. Based on RNA-sequencing data we established SOX10 and ANKRD55 expression as genes discriminating CNS_NBL from other tumors exhibiting CNS-PNET. Immunohistochemical detection of combined expression of SOX10 and ANKRD55 clearly identifies CNS_NBL discriminating them to other hemispheric CNS neoplasms harboring “PNET-like” microscopic appearance. Owing the rarity of CNS_NBL, a confirmation of the elaborated diagnostic IHC algorithm will be necessary in prospective patient series.

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