Fluorescent studies on the interaction of DNA and ternary lanthanide complexes with cinnamic acid-phenanthroline and antibacterial activities testing

Luminescence ◽  
2014 ◽  
Vol 30 (2) ◽  
pp. 131-136 ◽  
Author(s):  
Hui-Juan Sun ◽  
Ai-Ling Wang ◽  
Hai-Bin Chu ◽  
Yong-Liang Zhao
Keyword(s):  
Cinnamic Acid ◽  
Lanthanide Complexes ◽  
Antibacterial Activities ◽  
Fluorescent Studies

scholarly journals Synthesis, antibacterial activity and DNA interactions of lanthanide(III) complexes of N(4)-substituted thiosemicarbazones

2018 ◽  
Vol 23 (2) ◽  
pp. 141-169 ◽  
Author(s):  
Juan-David Londoño-Mosquera ◽  
Alberto Aragón-Muriel ◽  
Dorian Polo Cerón
Keyword(s):  
Antibacterial Activity ◽  
Lanthanide Complexes ◽  
Thermal Analyses ◽  
Antibacterial Activities ◽  
Spectroscopic Studies ◽  
Metal Centers ◽  
Molar Ratios ◽  
Calf Thymus ◽  
Dna Strands ◽  
High Oxidative Stress

This paper reports the synthesis and detailed characterization of six novel lanthanide complexes of La(III), Eu(III) and Nd(III) with N(4)-substituted thiosemicarbazones derived from the 2-carboxybenzaldehyde. The IR, 1H-NMR and 13C-NMR spectroscopic studies confirmed the coordination of the thiocarbonyl (C=S), azomethine (C=N) and carboxylate (COO-) groups to the metal centers, and the carboxylate was coordinated in a bidentate manner. The elemental and thermal analyses suggest that lanthanide complexes were formed in 1:2 molar ratios (metal:ligand). The molar conductivity values confirmed the non-electrolytic nature of the complexes. The interaction of these complexes with calf thymus DNA (CT-DNA) was investigated by UV absorption and viscosity measurements. It was found that the Eu(III) and Nd(III) complexes could roll along the DNA strands through groove interactions. Furthermore, lanthanide complexes could promote the oxidative cleavage of plasmid pBR322 in a high-oxidative stress environment. Finally, the Schiff base ligands (L) and their complexes were evaluated for their antibacterial activities against gram-positive and gram-negative bacteria using a microdilution procedure. The results indicate that the lanthanide complexes exhibit more potent antibacterial activity than the free ligands.

Novel Cinnamic Acid Derivatives Containing the 1,3,4-Oxadiazole Moiety: Design, Synthesis, Antibacterial Activities, and Mechanisms

2021 ◽  
Author(s):  
Shaobo Wang ◽  
Jixiang Chen ◽  
Jing Shi ◽  
Zhijia Wang ◽  
Deyu Hu ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Antibacterial Activities ◽  
Design Synthesis ◽  
Cinnamic Acid Derivatives

scholarly journals Production of trans-cinnamic acid by whole-cell bioconversion from l-phenylalanine in engineered Corynebacterium glutamicum

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Jaewoo Son ◽  
Jun Hong Jang ◽  
In Hyeok Choi ◽  
Chang Gyu Lim ◽  
Eun Jung Jeon ◽  
...  
Keyword(s):  
Corynebacterium Glutamicum ◽  
Cinnamic Acid ◽  
Membrane Filtration ◽  
Biological Activities ◽  
Antibacterial Activities ◽  
Whole Cell ◽  
Recycling System ◽  
Base Solution ◽  
High Copy Number Plasmid ◽  
T7 Phage

Abstract Background trans-cinnamic acid (t-CA) is a phenylpropanoid with a broad spectrum of biological activities including antioxidant and antibacterial activities, and it also has high potential in food and cosmetic applications. Although significant progress has been made in the production of t-CA using microorganisms, its relatively low product titers still need to be improved. In this study, we engineered Corynebacterium glutamicum as a whole-cell catalyst for the bioconversion of l-phenylalanine (l-Phe) into t-CA and developed a repeated bioconversion process. Results An expression module based on a phenylalanine ammonia lyase-encoding gene from Streptomyces maritimus (SmPAL), which mediates the conversion of l-Phe into t-CA, was constructed in C. glutamicum. Using the strong promoter PH36 and ribosome binding site (RBS) (in front of gene 10 of the T7 phage), and a high-copy number plasmid, SmPAL could be expressed to levels as high as 39.1% of the total proteins in C. glutamicum. Next, to improve t-CA production at an industrial scale, reaction conditions including temperature and pH were optimized; t-CA production reached up to 6.7 mM/h in a bioreactor under optimal conditions (50 °C and pH 8.5, using NaOH as base solution). Finally, a recycling system was developed by coupling membrane filtration with the bioreactor, and the engineered C. glutamicum successfully produced 13.7 mM of t-CA (24.3 g) from 18.2 mM of l-Phe (36 g) and thus with a yield of 75% (0.75 mol/mol) through repetitive supplementation. Conclusions We developed a highly efficient bioconversion process using C. glutamicum as a biocatalyst and a micromembrane-based cell recycling system. To the best of our knowledge, this is the first report on t-CA production in C. glutamicum, and this robust platform will contribute to the development of an industrially relevant platform for the production of t-CA using microorganisms.

scholarly journals Novel 1,3,4-Oxadiazole Derivatives Containing a Cinnamic Acid Moiety as Potential Bactericide for Rice Bacterial Diseases

2019 ◽  
Vol 20 (5) ◽  
pp. 1020 ◽  
Author(s):  
Shaobo Wang ◽  
Xiuhai Gan ◽  
Yanju Wang ◽  
Shaoyuan Li ◽  
Chongfen Yi ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Predictive Ability ◽  
Antibacterial Activities ◽  
Leaf Blight ◽  
Bacterial Leaf Blight ◽  
Acid Moiety ◽  
Bacterial Diseases ◽  
Oxadiazole Derivatives

Rice bacterial leaf blight and leaf streak are two important bacterial diseases of rice, which can result in yield loss. Currently, effective antimicrobials for rice bacterial diseases are still lacking. Thus, to develop highly effective and low-risk bactericides, 31 novel 1,3,4-oxadiazole derivatives containing a cinnamic acid moiety were designed and synthesized. Bioassay results demonstrated that all compounds exhibited good antibacterial activities in vitro. Significantly, compounds 5r and 5t showed excellent antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and X. oryzae pv. oryzicola (Xoc), with the 50% effective concentration (EC50) values of 0.58 and 0.34, and 0.44 and 0.20 μg/mL, respectively. These compounds were much better than thiodiazole copper (123.10 and 161.52 μg/mL) and bismerthiazol (85.66 and 110.96 μg/mL). Moreover, compound 5t had better protective and curative activities against rice bacterial leaf blight and leaf streak than thiodiazole copper and bismerthiazol in vivo. Simultaneously, the in vivo efficacy of the compounds was demonstrated by real-time quantitative PCR to quantify bacterial titers. In addition, a three-dimensional quantitative structure–activity relationship model was created and presented good predictive ability. This work provides support for 1,3,4-oxadiazole derivatives containing a cinnamic acid moiety as a potential new bactericide for rice bacterial diseases.

scholarly journals Determination of Phenolic Compounds in Various Propolis Samples Collected from an African and an Asian Region and Their Impact on Antioxidant and Antibacterial Activities

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4589
Author(s):  
Soumaya Touzani ◽  
Hamada Imtara ◽  
Shankar Katekhaye ◽  
Hamza Mechchate ◽  
Hayat Ouassou ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Antibacterial Properties ◽  
Reducing Power ◽  
Antibacterial Activities ◽  
Total Phenolic ◽  
Bacterial Strains ◽  
Photodiode Array Detection

The biological activities of propolis samples are the result of many bioactive compounds present in the propolis. The aim of the present study was to determine the various chemical compounds of some selected propolis samples collected from Palestine and Morocco by the High-Performance Liquid Chromatography–Photodiode Array Detection (HPLC-PDA) method, as well as the antioxidant and antibacterial activities of this bee product. The chemical analysis of propolis samples by HPLC-PDA shows the cinnamic acid content in the Palestinian sample is higher compared to that in Moroccan propolis. The results of antioxidant activity demonstrated an important free radical scavenging activity (2,2-Diphenyl-1-picrylhydrazyl (DPPH); 2,2′-azino-bis 3-ethylbenzothiazoline-6-sulphonic acid (ABTS) and reducing power assays) with EC50 values ranging between 0.02 ± 0.001 and 0.14 ± 0.01 mg/mL. Additionally, all tested propolis samples possessed a moderate antibacterial activity against bacterial strains. Notably, Minimum Inhibitory Concentrations (MICs) values ranged from 0.31 to 2.50 mg/mL for Gram-negative bacterial strains and from 0.09 to 0.125 mg/mL for Gram-positive bacterial strains. The S2 sample from Morocco and the S4 sample from Palestine had the highest content of polyphenol level. Thus, the strong antioxidant and antibacterial properties were apparently due to the high total phenolic and flavone/flavonol contents in the samples. As a conclusion, the activities of propolis samples collected from both countries are similar, while the cinnamic acid in the Palestinian samples was more than that of the Moroccan samples.

Lanthanide Complexes with 2,3-Dimethoxybenzoic Acid and Terpyridine: Crystal Structures, Thermal Properties, and Antibacterial Activities

2017 ◽  
Vol 643 (14) ◽  
pp. 889-894 ◽  
Author(s):  
Pan-Pan Shen ◽  
Xiao-Hui Wu ◽  
Ning Ren ◽  
Jian-Jun Zhang ◽  
Shu-Ping Wang
Keyword(s):  
Thermal Properties ◽  
Crystal Structures ◽  
Lanthanide Complexes ◽  
Antibacterial Activities

Synthesis, thermodynamic properties and antibacterial activities of lanthanide complexes with 3,5-dimethoxybenzoic acid and 1,10-phenanthroline

2013 ◽  
Vol 572 ◽  
pp. 101-106 ◽  
Author(s):  
Jun-Ru Zheng ◽  
Shu-Xia Ren ◽  
Ning Ren ◽  
Jian-Jun Zhang ◽  
Da-Hai Zhang ◽  
...  
Keyword(s):  
Thermodynamic Properties ◽  
Lanthanide Complexes ◽  
Antibacterial Activities

Synthesis and thermal decomposition kinetics of two lanthanide complexes with cinnamic acid and 2,2′-Bipyridine

2009 ◽  
Vol 99 (1) ◽  
pp. 349-356 ◽  
Author(s):  
L. Tian ◽  
N. Ren ◽  
J. J. Zhang ◽  
H. M. Liu ◽  
S. J. Sun ◽  
...  
Keyword(s):  
Thermal Decomposition ◽  
Cinnamic Acid ◽  
Lanthanide Complexes ◽  
Decomposition Kinetics ◽  
Thermal Decomposition Kinetics ◽  
Kinetics Of

Spectra, energy levels, and energy transition of lanthanide complexes with cinnamic acid and its derivatives

2016 ◽  
Vol 158 ◽  
pp. 29-33 ◽  
Author(s):  
Kaining Zhou ◽  
Zhongshan Feng ◽  
Jun Shen ◽  
Bing Wu ◽  
Xiaobing Luo ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Lanthanide Complexes ◽  
Energy Levels ◽  
Energy Transition
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