Chemometric analysis of active compounds and antioxidant and α‐glucosidase inhibitory activities for the quality evaluation of licorice from different origins

2021 ◽  
Author(s):  
Xuemei Zhang ◽  
Xinhua Guo ◽  
Ping Zhao ◽  
Xuemin Zhang ◽  
Wenyuan Gao ◽  
...  
Keyword(s):  
Quality Evaluation ◽  
Chemometric Analysis ◽  
Active Compounds ◽  
Inhibitory Activities ◽  
Different Origins

scholarly journals Plant Growth Inhibitory Activities and Volatile Active Compounds of 53 Spices and Herbs

Plants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 264 ◽  
Author(s):  
Takayuki Sekine ◽  
Kwame Sarpong Appiah ◽  
Majid Azizi ◽  
Yoshiharu Fujii
Keyword(s):  
Growth Inhibition ◽  
Total Activity ◽  
Inhibitory Effect ◽  
Gas Chromatography Mass Spectrometry ◽  
Thymus Vulgaris ◽  
Anethum Graveolens ◽  
Hypocotyl Growth ◽  
Radicle Growth ◽  
Active Compounds ◽  
Inhibitory Activities

The inhibitory activities of the leachates and volatiles from 53 plant species (spices and herbs) were evaluated against lettuce (Lactuca sativa “Great Lakes 366”) seedling growth using the sandwich and dish pack methods, respectively. With the sandwich method, parsley (Petroselinum sativum) showed the strongest inhibitory effect on lettuce radicle growth (77%), followed by tarragon (Artemisia dracunculus) (72%). However, caraway (Carum carvi), dill (Anethum graveolens) (seed), laurel (Laurus nobilis), rosemary (Rosmarinus officinalis), and sage (Salvia officinalis) were the most inhibitory species (100% inhibition of lettuce radicle and hypocotyl growth inhibition at all distance wells) in the dish pack method. Cardamom (Elettaria cardamomum) and thyme (Thymus vulgaris) also showed strong inhibitory activity (100% for radicle and hypocotyl growth inhibition at all 41 and 58 mm distance wells). The headspace sampling and gas chromatography-mass spectrometry (GC-MS) analysis identified the main inhibitory active compounds as carvone in caraway and dill (seeds), 1,8-cineole in laurel and cardamom, and borneol in thyme. Both camphor and 1,8-cineole were detected in rosemary and sage, and the total activity evaluation showed that camphor was the major inhibitory compound in rosemary, although both compounds played equal roles in sage.

Synthesis and bioactivity of novel C2-glycosyl benzofuranylthiazoles derivatives as acetylcholinesterase inhibitors

2019 ◽  
Vol 43 (7-8) ◽  
pp. 257-261
Author(s):  
Lei Wang ◽  
Yu-Ran Wu ◽  
Shu-Ting Ren ◽  
Long Yin ◽  
You-Xian Wang ◽  
...  
Keyword(s):  
Inhibitory Concentration ◽  
Acetylcholinesterase Inhibitors ◽  
Acetylcholinesterase Inhibition ◽  
Inhibition Activity ◽  
Active Compounds ◽  
Inhibitory Activities ◽  
Ellman’S Method

A new series of C2-glycosyl benzofuranylthiazole derivatives was synthesised by the further cyclization of glycosyl thiourea and 2-(bromoacetyl)-benzofuran via Hantzsch’s method. The corresponding 2-(bromoacetyl)-benzofuran derivatives were obtained by the reaction from various salicylaldehydes, and the glycosyl thiourea was prepared through a series of steps from D-Glucosamine. The acetylcholinesterase-inhibitory activities of the products were tested by Ellman’s method. The most active compounds were subsequently evaluated for the 50% inhibitory concentration values. N-(1,3,4,6-tetra-O-benzyl-2-deoxy-β-D-glucopyranosyl)-4-(5-methoxy-benzofuran-2-yl)-1,3-thiazole-2-amine possessed the best acetylcholinesterase-inhibition activity with a 50% inhibitory concentration of 2.03 ± 0.26 μM.

scholarly journals Development of HPLC Fingerprint for Quality Assessment of Bulbus Lilii

2013 ◽  
Vol 8 (10) ◽  
pp. 1934578X1300801
Author(s):  
Kunming Qin ◽  
Hao Cai ◽  
Lijuan Zheng ◽  
Miao Zhang ◽  
Xinghai Zhang ◽  
...  
Keyword(s):  
High Performance ◽  
Quality Evaluation ◽  
Quality Analysis ◽  
Analysis Method ◽  
Hplc Fingerprint ◽  
Array Detection ◽  
Different Origins ◽  
First Time ◽  
And Storage

In this study, a simple, sensitive and reliable fingerprint analysis method by high-performance liquid chromatography coupled with diode array detection (HPLC-DAD) was developed for quality analysis of Bulbus Lilii, which is a famous traditional Chinese medicine and widely used as a restorative food. Then the developed method was subsequently applied to analyse 16 samples collected or purchased from different origins. Twelve common fingerprint peaks, including four definitely identified peaks, were found in total, and were involved for further characterisation and quality evaluation of Bulbus Lilii. The chemical quality of commercial samples collected from different origins varied obviously, indicating that more attention should be paid to the standardisation of the process of harvesting, manufacturing and storage of Bulbus Lilii. This is the first time that a new method has been established to control the quality of Bulbus Lilii through HPLC-DAD.

scholarly journals Green Tea Quality Evaluation Based on Its Catechins and Metals Composition in Combination with Chemometric Analysis

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1689 ◽  
Author(s):  
Wojciech Koch ◽  
Wirginia Kukula-Koch ◽  
Łukasz Komsta ◽  
Zbigniew Marzec ◽  
Wojciech Szwerc ◽  
...  
Keyword(s):  
Green Tea ◽  
Quality Evaluation ◽  
Chemometric Analysis ◽  
Tea Quality

scholarly journals Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge Astrosclera willeyana

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 361
Author(s):  
Wei Jiang ◽  
Dongdong Wang ◽  
Brice A. P. Wilson ◽  
Unwoo Kang ◽  
Heidi R. Bokesch ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Spectroscopic Data ◽  
Active Compounds ◽  
Spectrometric Data ◽  
Ubiquitin Ligase Activity ◽  
Ic50 Values ◽  
Inhibitory Activities ◽  
Immunomodulatory Protein ◽  
New Compounds

An extract of the coralline demosponge Astrosclera willeyana inhibited the ubiquitin ligase activity of the immunomodulatory protein Cbl-b. The bioassay-guided separation of the extract provided ten active compounds, including three new N-methyladenine-containing diterpenoids, agelasines W–Y (1–3), a new bromopyrrole alkaloid, N(1)-methylisoageliferin (4), and six known ageliferin derivatives (5–10). The structures of the new compounds were elucidated from their spectroscopic and spectrometric data, including IR, HRESIMS, and NMR, and by comparison with spectroscopic data in the literature. While all of the isolated compounds showed Cbl-b inhibitory activities, ageliferins (4–10) were the most potent metabolites, with IC50 values that ranged from 18 to 35 μM.

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