scholarly journals Genetic variation of rs12918566 affects GRIN2A expression and is associated with spontaneous movement response during sevoflurane anesthesia induction

2021 ◽  
Author(s):  
Ming‐Hua Chen ◽  
Chao Fang ◽  
Na‐Yiyuan Wu ◽  
Yu‐Hao Xia ◽  
You‐Jie Zeng ◽  
...  

2021 ◽  
Vol 10 (4) ◽  
pp. 662
Author(s):  
Eun-Hee Kim ◽  
Young-Eun Jang ◽  
Sang-Hwan Ji ◽  
Ji-Hyun Lee ◽  
Sung-Ae Cho ◽  
...  

We investigated changes in plasma glial fibrillary acidic protein concentration during sevoflurane anesthesia induction in children < 3 years old and determined the effect of co-administering dexmedetomidine. This preliminary randomized trial included 60 pediatric patients who received sevoflurane anesthesia for >3 h. Patients were assigned to dexmedetomidine or control groups at a 1:1 ratio. The primary outcome was changes in plasma glial fibrillary acidic protein concentration of dexmedetomidine and control groups over time. Fifty-five patients were included in the final analysis. The median (interquartile range (IQR)) of the plasma glial fibrillary acidic protein level was 387.7 (298.9–510.8) pg·mL−1 immediately after anesthetic induction, 302.6 (250.9–412.5) pg·mL−1 at 30 min, and 321.9 (233.8–576.2) pg·mL−1 at 180 min after the first sample. These values did not change over time (p = 0.759). However, plasma glial fibrillary acidic protein increased after 180 min of infusion of dexmedetomidine compared with values at 30 min infusion (p = 0.04, mean difference and 95% confidence interval of 221.6 and 2.2 to 441.0 pg·mL−1). In conclusion, three hours of sevoflurane anesthesia in pediatric patients < 3 years old did not provoke neuronal injury assessed by the plasma biomarker. Further studies regarding the effect of prolonged dexmedetomidine infusion on anesthetic neuronal injury are required.



Author(s):  
Mehmet Sahap ◽  
Handan Gulec ◽  
Esra ozayar ◽  
Ozlem zdemir ◽  
Merve Kacan ◽  
...  

Purpose : Rocuronium bromide is a painful agent while general anesthesia induction. The aim of the study is to investigate the effects of cox inhibitors as a resque agent against the rocuronium pain Methodology : Sixty patients enrolled for the general anesthesia enrolled in this study. Patients were allocated into two groups (Group 1: Dexkethoprofen group, Group 2: Control group) .Pain was evaluated by during rocuronium injection, patients were scored by a scale showed below. 0;No movement response to injection 1;Mild movement response to injection 2;Hand withdrawal response to injection 3;Arm withdrawal response to injection We also evaluated the pain with 2 questions when the patient was in the recovery room.Question 1.What was the last feeling before you fall into sleep? and question 2. Did you feel any pain on your hand during medication injection for anesthesia? Results:There were differences between the groups in terms of total pain score for example in group 1 there were 16 (53%) patients who did not make any movement during rocuronium injection while there were 22 (73%) patients in group 2.There was significant difference in injection rocuronium bromide pain between group 1: dexkethoprofen group, Group 2: control group in terms of the answer to the second question.Patients felt less pain than the control group. Conclusion:The effect of cox inhibitors on rocuronium pain was seen in our study but check is also effective in reducing pain in vascular width.



1972 ◽  
Vol 35 (2) ◽  
pp. 435-436 ◽  
Author(s):  
Marcia Guttentag

Spontaneous movement responses of Negro and white lower-class and white middle-class 4-yr.-olds were recorded on video tape under several controlled conditions. Tapes were coded for total movement and for gross movement response. Negro children emitted a significantly greater number of movement responses and a greater variety of movement response than did both white groups.





2009 ◽  
Vol 5 (5) ◽  
pp. 37
Author(s):  
V. V. Lazarev ◽  
L. Ye. Tsypin ◽  
T. V. Linkova ◽  
V. S. Kochkin ◽  
T. G. Popova ◽  
...  


1999 ◽  
Vol 46 (3) ◽  
pp. 240-246 ◽  
Author(s):  
Normand R. Gravel ◽  
Norman R. Searle ◽  
Jean Taillefer ◽  
Michel Carrier ◽  
Micheline Roy ◽  
...  


2011 ◽  
Vol 153 (2) ◽  
pp. 86-88 ◽  
Author(s):  
C. Adami ◽  
L. O. Levionnois ◽  
C. Spadavecchia


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