Biocatalytic Process Optimization for the Production of High-Added-Value 6-O-Hydroxy and 3-O-Hydroxy Glycosyl Building Blocks

ChemCatChem ◽  
2017 ◽  
Vol 9 (13) ◽  
pp. 2536-2543 ◽  
Author(s):  
Ciara Callaghan ◽  
Martin Redmond ◽  
Robson Carlos Alnoch ◽  
Cesar Mateo ◽  
Marco Filice ◽  
...  
Author(s):  
Daniel Derrell Forest ◽  
G.H. Massiha

<span>The purpose of this project is to evaluate and optimize an assembly process for ergonomic and productivity considerations. Companies use lean manufacturing as a method for continuous improvement in order to increase throughput and for to reallocate resources for more important tasks. For this project, value stream mapping (VSM) was used to evaluate, analyze, and improve the ergonomic factors of an assembly process and to increasing throughput. With the use of VSM, researchers are able to see the areas of added value, non-added value, and bottlenecks. This project illustrates the implementation of VSM for the minimization of waste, by using the design method to restructure the process of assembly. The results show drastic improvement in assembly time and ergonomic workplace design, while providing a platform for a continuous improvement system.</span>


2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Stijn Vandevelde ◽  
Freya Vander Laenen ◽  
Benjamin Mine ◽  
Eric Maes ◽  
Lana De Clercq ◽  
...  

Purpose This paper aims to report the findings of an evaluation study concerning the Central Registration Points (CRPs) for drug users in Belgian prisons. CRPs support drug users to link with community-based services. Design/methodology/approach The study applied a multi-method approach that involved an exploratory literature review; a secondary analysis of the CRPs’ databases; a qualitative study of the perceptions of a diverse sample of stakeholders with regard to the functioning of CRPs; and a prospective registration study. Findings One-third of the clients never attended an outpatient or residential substance abuse service before prison entry. This illustrates that the CRPs managed to reach clients who were not previously reached by (substance abuse) treatment services. All interviewed actors emphasized the added value of the CRPs in terms of informing, contacting, motivating and referring prisoners with a substance abuse problem. Practical implications Based on the research findings, two issues seem to be of paramount importance in the successful practice of CRPs: the confidentiality and specific expertise on (substance abuse) treatment. Given the complex situation of drug users in prison, an independent positioning and categorical assistance with drug-specific expertise seem to be essential. Originality/value CRPs can be considered to be one of the “building blocks” that contribute to high-quality care and continuity of care for drugs users in detention.


2021 ◽  
Vol 17 ◽  
pp. 589-621
Author(s):  
Francesca Liguori ◽  
Carmen Moreno-Marrodán ◽  
Pierluigi Barbaro

Metal-catalysed depolymerisation of plastics to reusable building blocks, including monomers, oligomers or added-value chemicals, is an attractive tool for the recycling and valorisation of these materials. The present manuscript shortly reviews the most significant contributions that appeared in the field within the period January 2010–January 2020 describing selective depolymerisation methods of plastics. Achievements are broken down according to the plastic material, namely polyolefins, polyesters, polycarbonates and polyamides. The focus is on recent advancements targeting sustainable and environmentally friendly processes. Biocatalytic or unselective processes, acid–base treatments as well as the production of fuels are not discussed, nor are the methods for the further upgrade of the depolymerisation products.


Processes ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 366 ◽  
Author(s):  
Alberto Mannu ◽  
Sebastiano Garroni ◽  
Jesus Ibanez Porras ◽  
Andrea Mele

Recently, the interest in converting waste cooking oils (WCOs) to raw materials has grown exponentially. The driving force of such a trend is mainly represented by the increasing number of WCO applications, combined with the definition, in many countries, of new regulations on waste management. From an industrial perspective, the simple chemical composition of WCOs make them suitable as valuable chemical building blocks, in fuel, materials, and lubricant productions. The sustainability of such applications is sprightly related to proper recycling procedures. In this context, the development of new recycling processes, as well as the optimization of the existing ones, represents a priority for applied chemistry, chemical engineering, and material science. With the aim of providing useful updates to the scientific community involved in vegetable oil processing, the current available technologies for WCO recycling are herein reported, described, and discussed. In detail, two main types of WCO treatments will be considered: chemical transformations, to exploit the chemical functional groups present in the waste for the synthesis of added value products, and physical treatments as extraction, filtration, and distillation procedures. The first part, regarding chemical synthesis, will be connected mostly to the production of fuels. The second part, concerning physical treatments, will focus on bio-lubricant production. Moreover, during the description of filtering procedures, a special focus will be given to the development and applicability of new materials and technologies for WCO treatments.


Author(s):  
Diogo A. Ferreira-Filipe ◽  
Ana Paço ◽  
Armando C. Duarte ◽  
Teresa Rocha-Santos ◽  
Ana L. Patrício Silva

Environmental sustainability is driving an intense search for “green materials”. Biobased plastics have emerged as a promising alternative. Their building blocks can now be obtained from diverse biomass, by-products, and organic residues due to the advances in biorefineries and bioprocessing technologies, decreasing the demand for fossil fuel resources and carbon footprint. Novel biobased polymers with high added value and improved properties and functionalities have been developed to apply diverse economic sectors. However, the real opportunities and risks of such novel biobased plastic solutions have raised scientific and public awareness. This paper provides a critical review on the recent advances in biobased polymers chemistry and emerging (bio)technologies that underpin their production and discusses the potential for biodegradation, recycling, environmental safety, and toxicity of these biobased solutions.


2021 ◽  
Author(s):  
Daniel Hernandez-Deckers ◽  
Toshihisa Matsui ◽  
Ann M. Fridlind

Abstract. One fundamental question about atmospheric moist convection processes that remains debated is whether or under what conditions a relevant variability in background aerosol concentrations may have a significant dynamical impact on convective clouds and their associated precipitation. Furthermore, current climate models must parameterize both the microphysical and the cumulus convection processes, but this is usually implemented separately, whereas in nature there is a strong coupling between them. As a first step to improve our understanding of these two problems, we investigate how aerosol concentrations modify key properties of updrafts in eight large-eddy permitting regional simulations of a case study of scattered convection over Houston, Texas, in which convection is explicitly simulated and microphysical processes are parameterized. Dynamical and liquid-phase microphysical responses are investigated using two different reference frames: static cloudy-updraft grid cells versus tracked cumulus thermals. In both frameworks we observe the expected microphysical responses to higher aerosol concentrations, such as higher cloud number concentrations and lower rain number concentrations. In terms of the dynamical responses, both frameworks indicate weak impacts of varying aerosol concentrations relative to the noise between simulations over the observationally derived range of aerosol variability for this case study. On the other hand, results suggest that analysis of thermals can provide a better pathway to sample the most relevant convective processes. For instance, vertical velocity from thermals is significantly higher at upper levels than when sampled from cloudy-updraft grid points, and several microphysical variables have higher average values in the cumulus thermal framework than in the cloudy-updraft framework. In addition, the thermal analysis is seen to add rich quantitative information about the rates and covariability of microphysical processes spatially and throughout tracked thermal lifecycles, which can serve as a stronger foundation for improving subgrid-scale parameterizations. These results suggest that cumulus thermals are more realistic dynamical building blocks of cumulus convection, acting as natural cloud chambers for microphysical processes.


Author(s):  
Igor Karlovits ◽  

The concept of efficient utilisation of renewable bio-based materials (biomass feedstock) is the driving force in the green transformation to a more sustainable and circular society. Biorefineries or biochemical platforms convert and utilise different sources of biomass into fuels and other beneficial derivates like fibres and other bio-based chemicals. These can be used as building blocks for many potentially useful applications. In this review, we shall describe the current state of the art and trends in the conversion of lignocellulosic feedstock into materials which can be primarily used in packaging applications. The three main constituents (cellulose, hemicellulose and lignin) are being re-engineered into new products with higher added value. The main goal of all these downstream products is that they do not compete with animal feed and food applications. The main downstream products of different kind of transformations are different natural fibres which can be further processed into micro or nano fibrillated state and used for a broad application of fields from ink, adhesive and packaging materials. Also, fibres and its derivates can be bonded successfully into bio-composites or fibre-based foams applications for the protective packaging applications. Hemicellulose, as a second most abundant component, has been researched for applications in adhesives and paper and paperboard coatings. Lignin which is currently utilised as an energy source for the paper industry, has been recently actively researched. Lignin-based biopolymers have a potential to be used in many different applications from additives in the barrier coatings on the packaging to active packaging and even as lignin-based foams. All these applications are currently in the development stages and cover niche market segments, but are expected to grow and to be used in future markets.


2021 ◽  
Author(s):  
Sarabindu Roy ◽  
Ajay Yadaw ◽  
Subho Roy ◽  
Gopal Sirasani ◽  
Joseph D. Armstrong ◽  
...  

<div> <div> <p>Pyrrolo[2,1-f][1,2,4]triazine (<b>1</b>) is an important regulatory starting material in the production of Remdesivir (Veklury®). Compound<b> 1</b> was produced through a newly developed synthetic methodology utilizing the simple building blocks pyrrole, chloramine and formamidine acetate by examining the mechanistic pathway for the process optimization exercise. Triazine <b>1</b> was obtained in 55% overall yield in a two-reactor operated process. This work describes the safety of the process, impurity profiles and control, and efforts towards the scale-up of triazine for the preparation of kilogram quantity.</p> </div> </div> <br>


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