ChemInform Abstract: Radical Cyclization Using a Thioacetal Group for Radical Generation.

An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitriles to synthesise biologically important phenanthridines. The synthetic value of this protocol can be further illustrated by the modification of quinoxalin-2-ones, containing important natural products and drug-based complex molecules.

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Radical cyclization using a thioacetal group for radical generation

Tetrahedron ◽

10.1016/0040-4020(96)00511-x ◽

1996 ◽

Vol 52 (29) ◽

pp. 9713-9734 ◽

Cited By ~ 22

Author(s):

Atsushi Nishida ◽

Norio Kawahara ◽

Mayumi Nishida ◽

Osamu Yonemitsu

Keyword(s):

Radical Cyclization ◽

Radical Generation

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Visible-Light Photosensitized Aryl and Alkyl Decarboxylative Carbon-Heteroatom and Carbon-Carbon Bond Formations

10.26434/chemrxiv.7995983.v1 ◽

2019 ◽

Author(s):

Tuhin Patra ◽

Satobhisha Mukherjee ◽

Jiajia Ma ◽

Felix Strieth-Kalthoff ◽

Frank Glorius

Keyword(s):

Energy Transfer ◽

Visible Light ◽

Alkyl Radical ◽

General Strategy ◽

Alkyl Radicals ◽

Bond Forming ◽

Radical Trapping ◽

Carbon Carbon Bond ◽

Radical Generation ◽

Trapping Agent

<sub>A general strategy to access both aryl and alkyl radicals by photosensitized decarboxylation of the corresponding carboxylic acids esters has been developed. An energy transfer mediated homolysis of unsymmetrical sigma-bonds for a concerted fragmentation/decarboxylation process is involved. As a result, an independent aryl/alkyl radical generation step enables a series of key C-X and C-C bond forming reactions by simply changing the radical trapping agent.</sub>

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In-vivo anti-oxidant screening of Tectona grandis extract

International Research Journal of Pharmaceutical and Applied Sciences ◽

10.26452/irjpas.v9i1.1164 ◽

2020 ◽

Vol 9 (1) ◽

pp. 1-4

Author(s):

Tamilarasi G P ◽

Sabarees G

Keyword(s):

Biochemical Parameters ◽

Tectona Grandis ◽

The Body ◽

Altered Expression ◽

Physiological Conditions ◽

Synthetic Drugs ◽

Significant Difference ◽

Anti Oxidant ◽

Radical Generation

Oxidation is an essential reaction in the human body, which determines the expression of proteins in the body. This results in the altered expression like rapid growth resulting in cancers and other disorders. Many synthetic drugs are available in the market that is effective in limiting the free radical generation and the reaction of radicals with cells. Unfortunately, all those synthetic drugs were found to cause side effects and adverse effects in the body. But given the accuracy of the predictability of the results and administration, this research focuses on testing the anti-oxidant efficiency in rat models testing the biochemical parameters. Investigations have also been done on the anti-oxidant activity of Tectona, but every research was concentrated to prove the anti-oxidant activity only. extract had been tested for anti-oxidant activity by estimating various tissue parameters and it showed better activity. As predicted, there is a significant difference in the and results which can be explained are due to the physiological conditions that exist inside the body.

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Synthesis of Heterocyclic Compounds by the Application of Radical Cyclization

Journal of Chemistry and Chemical Sciences ◽

10.29055/jccs/623 ◽

2018 ◽

Vol 8 (4) ◽

pp. 660-670

Author(s):

Sanjay Nath

Keyword(s):

Heterocyclic Compounds ◽

Radical Cyclization

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Superoxide Anion Radical: Generation and Detection in Cellular and Non-Cellular Systems

Current Medicinal Chemistry ◽

10.2174/0929867322666151029104311 ◽

2015 ◽

Vol 22 (37) ◽

pp. 4234-4256 ◽

Cited By ~ 10

Author(s):

Renan Chiste ◽

Marisa Freitas ◽

Adriana Mercadante ◽

Eduarda Fernandes

Keyword(s):

Superoxide Anion ◽

Anion Radical ◽

Cellular Systems ◽

Superoxide Anion Radical ◽

Radical Generation

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Recent advances in Minisci-type reactions and applications in organic synthesis

Current Organic Chemistry ◽

10.2174/1385272824999201230211157 ◽

2020 ◽

Vol 24 ◽

Author(s):

Wengui Wang ◽

Shoufeng Wang

Keyword(s):

Free Radical ◽

Hydrogen Atom ◽

Organic Synthesis ◽

Radical Reactivity ◽

Atom Loss ◽

Radical Generation ◽

In Situ Generation ◽

Thermal Cleavage ◽

Synthetic Chemist

Abstract:: Minisci-type reactions have become widely known as reactions that involve the addition of carbon-centered radicals to basic heteroarenes followed by formal hydrogen atom loss. While the originally developed protocols for radical generation remain in active use today, in recent years by a new array of radical generation strategies allow use of a wider variety of radical precursors that often operate under milder and more benign conditions. New transformations based on free radical reactivity are now available to a synthetic chemist looking to utilize a Minisci-type reaction. Radical-generation methods based on photoredox catalysis and electrochemistry, which utilize thermal cleavage or the in situ generation of reactive radical precursors, have become popular approaches. Our review will cover the remarkably literature that has appeared on this topic in recent 5 years, from 2015-01 to 2020-01, in an attempt to provide guidance to the synthetic chemist, on both the challenges that have been overcome and applications in organic synthesis.

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An overview on therapeutic potential of Iris Persica

Current Traditional Medicine ◽

10.2174/2215083806666200117111320 ◽

2020 ◽

Vol 06 ◽

Author(s):

Faiq H. S. Hussain ◽

Hawraz Ibrahim M. Amin ◽

Dinesh kumar Patel ◽

Omji Porwal

Keyword(s):

Therapeutic Potential ◽

Biological Activities ◽

Folk Medicine ◽

Underground Storage ◽

Kurdistan Region ◽

Traditional Medicines ◽

The Family ◽

Storage Organs ◽

Radical Generation ◽

Perennial Herbs

: The family Iridaceae contains 92 genera and more than 1800 species, mostly perennial herbs with underground storage organs called rhizomes (bulbs). Some genera are important in traditional medicines, especially Iris and Gladiolus. The genus Iris belongs to this family and comprises about hundreds species among them, 12 species are found in Iraq. It has been widely used various medicines worldwide especially Iris persica is used in folk medicine in the Kurdistan region of Iraq as an effective treatment against tumours, antibacterial, antifungal and treating inflammation. Earlier finding confirmed that Iris persica and its constituents play role in the scavenging of free radical generation and prevention of disease pathogenesis. Each part of the Iris persica herb has some medicinal property. This review gives a eagle eye view mainly on the biological activities of the Iris persica and some of their compounds isolated, pharmacological actions of the Iris persica extracts and products, and plausible medicinal and therapeutically applications.

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