ChemInform Abstract: BE-31405, a New Antifungal Antibiotic Produced by Penicillium minioluteum. Part 1. Description of Producing Organism, Fermentation, Isolation, Physico-Chemical and Biological Properties.

Regenerative medicine represents an emerging multidisciplinary field that brings together engineering methods and complexity of life sciences into a unified fundamental understanding of structure-property relationship in micro/nano environment to develop the next generation of scaffolds and hydrogels to restore or improve tissue functions. Chitosan has several unique physico-chemical properties that make it a highly desirable polysaccharide for various applications such as, biomedical, food, nutraceutical, agriculture, packaging, coating, etc. However, the utilization of chitosan in regenerative medicine is often limited due to its inadequate mechanical, barrier and thermal properties. Cellulosic nanomaterials (CNs), owing to their exceptional mechanical strength, ease of chemical modification, biocompatibility and favorable interaction with chitosan, represent an attractive candidate for the fabrication of chitosan/ CNs scaffolds and hydrogels. The unique mechanical and biological properties of the chitosan/CNs bio-nanocomposite make them a material of choice for the development of next generation bio-scaffolds and hydrogels for regenerative medicine applications. In this review, we have summarized the preparation method, mechanical properties, morphology, cytotoxicity/ biocompatibility of chitosan/CNs nanocomposites for regenerative medicine applications, which comprises tissue engineering and wound dressing applications.

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Development and Pharmacokinetics Study of Antifungal Peptide Nanoliposomes by Liquid Chromatography-tandem Mass Spectrometry

Current Pharmaceutical Analysis ◽

10.2174/1573412914666180307155328 ◽

2019 ◽

Vol 15 (4) ◽

pp. 312-318

Author(s):

Shuoye Yang

Keyword(s):

Mass Spectrometry ◽

Biological Properties ◽

Pharmacokinetic Property ◽

Antifungal Peptide ◽

Simple Liquid ◽

Physico Chemical ◽

Liquid Chromatography Tandem Mass ◽

Pegylated Lipids

Background: The therapeutic ability and application of antifungal peptide (APs) are limited by their physico-chemical and biological properties, the nano-liposomal encapsulation would improve the in vivo circulation and stability. </P><P> Objective: To develop a long-circulating liposomal delivery systems encapsulated APs-CGA-N12 with PEGylated lipids and cholesterol, and investigated through in vivo pharmacokinetics. Methods: The liposomes were prepared and characterized, a rapid and simple liquid chromatographytandem mass spectrometry (LC-MS/MS) assay was developed for the determination of antifungal peptide in vivo, the pharmacokinetic characteristics of APs liposomes were evaluated in rats. Results: Liposomes had a large, unilamellar structure, particle size and Zeta potential ranged from 160 to 185 nm and -0.55 to 1.1 mV, respectively. The results indicated that the plasma concentration of peptides in reference solutions rapidly declined after intravenous administration, whereas the liposomeencapsulated ones showed slower elimination. The AUC(0-∞) was increased by 3.0-fold in liposomes in comparison with standard solution (20 mg·kg-1), the half-life (T1/2) was 1.6- and 1.5-fold higher compared to the reference groups of 20 and 40 mg·kg-1, respectively. Conclusion: Therefore, it could be concluded that liposomal encapsulation effectively improved the bioavailability and pharmacokinetic property of antifungal peptides.

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Progress and Prospects in Translating Nanobiotechnology in Medical Theranostics

Current Nanoscience ◽

10.2174/1573413715666191126093258 ◽

2020 ◽

Vol 16 (5) ◽

pp. 685-707 ◽

Cited By ~ 1

Author(s):

Amna Batool ◽

Farid Menaa ◽

Bushra Uzair ◽

Barkat Ali Khan ◽

Bouzid Menaa

Keyword(s):

Biological Properties ◽

Chemical Characteristics ◽

Intrinsic Properties ◽

The Past ◽

Profound Influence ◽

Functionalized Nanomaterials ◽

Physico Chemical ◽

Properties Of Materials ◽

Targeted Drug ◽

And Performance

: The pace at which nanotheranostic technology for human disease is evolving has accelerated exponentially over the past five years. Nanotechnology is committed to utilizing the intrinsic properties of materials and structures at submicroscopic-scale measures. Indeed, there is generally a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical characteristics, biological properties, and performance. The exploration of nature’s components to work effectively as nanoscaffolds or nanodevices represents a tremendous and growing interest in medicine for various applications (e.g., biosensing, tunable control and targeted drug release, tissue engineering). Several nanotheranostic approaches (i.e., diagnostic plus therapeutic using nanoscale) conferring unique features are constantly progressing and overcoming all the limitations of conventional medicines including specificity, efficacy, solubility, sensitivity, biodegradability, biocompatibility, stability, interactions at subcellular levels. : This review introduces two major aspects of nanotechnology as an innovative and challenging theranostic strategy or solution: (i) the most intriguing (bare and functionalized) nanomaterials with their respective advantages and drawbacks; (ii) the current and promising multifunctional “smart” nanodevices.

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Biological Function and Chemistry of Endothelin. A Review

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19991211 ◽

1999 ◽

Vol 64 (8) ◽

pp. 1211-1252 ◽

Cited By ~ 4

Author(s):

Jan Hlaváček ◽

Renáta Marcová

Keyword(s):

Biological Activity ◽

Amino Acid ◽

Biological Function ◽

Biological Properties ◽

Structural Basis ◽

Amino Acid Residues ◽

Snake Venoms ◽

Vasoactive Peptides ◽

Physico Chemical ◽

Endothelin A

The first part of this review deals with the biosynthesis and a biological function of strongly vasoactive peptides named endothelins (ETs) including vasoactive intestinal contractor. Where it was useful, snake venoms sarafotoxins which are structural endothelin derivatives, were also mentioned. In the second part, an attention is paid to structural basis of the ETs biological activity, with respect to alterations of amino acid residues in the parent peptides modifying the conformation and consequently the physico-chemical and biological properties in corresponding ETs analogs. Special attention is focussed on the area of ETs receptors and their interaction with peptide and non peptide agonists and antagonists, important in designing selective inhibitors of ETs receptors potentially applicable as drugs in a medicine. A review with 182 references.

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Plants arabinogalactans: From structures to physico-chemical and biological properties

Biotechnology Advances ◽

10.1016/j.biotechadv.2021.107771 ◽

2021 ◽

pp. 107771

Author(s):

S. Saiedy ◽

B. Petera ◽

G. Pierre ◽

T.A. Fenoradosoa ◽

Djomdi Djomdi ◽

...

Keyword(s):

Biological Properties ◽

Physico Chemical

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