ChemInform Abstract: Isolation of 8′-Phosphate Ester Derivatives of Amicoumacins: Structure-Activity Relationship of Hydroxy Amino Acid Moiety.

ChemInform ◽  
2008 ◽  
Vol 39 (26) ◽  
Author(s):  
Makoto Hashimoto ◽  
Takaaki Taguchi ◽  
Satoshi Nishida ◽  
Kouji Ueno ◽  
Kaio Koizumi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Phosphate Ester ◽  
Acid Moiety ◽  
Hydroxy Amino Acid ◽  
Structure Activity ◽  
Amino Acid Moiety ◽  
Relationship Of ◽  
Derivatives Of

Synthesis of Hippospongic Acid A Analogues Designed for Investigating the Structure-Activity Relationship of its Biological Activity

2000 ◽  
Vol 53 (12) ◽  
pp. 909 ◽  
Author(s):  
Yoshikazu Hiraga ◽  
Mariko Ago ◽  
Munetaka Tokumasu ◽  
Ken Kaku ◽  
Katsuo Ohkata
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Sea Urchin ◽  
Essential Feature ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Acid Moiety ◽  
Sea Urchin Embryos ◽  
Structure Activity ◽  
Relationship Of

Analogues of hippospongic acid A, which inhibit the gastrulation of sea urchin embryos, were synthesized. From a study on structure—activity relationships, the conjugated carboxylic acid moiety was found to be an essential feature for biological activity.

scholarly journals From in vitro to in cellulo: structure–activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa

2014 ◽  
Vol 12 (32) ◽  
pp. 6094-6104 ◽  
Author(s):  
Michael P. Storz ◽  
Giuseppe Allegretta ◽  
Benjamin Kirsch ◽  
Martin Empting ◽  
Rolf W. Hartmann
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Relationship Of ◽  
Derivatives Of

More than 60 derivatives of (2-nitrophenyl)methanol were synthesized and evaluated regarding their potency to inhibit PqsD. In vitro and in cellulo structure–activity relationships were derived.

Structure–activity relationship of boronic acid derivatives of tyropeptin: Proteasome inhibitors

2010 ◽  
Vol 20 (19) ◽  
pp. 5839-5842 ◽  
Author(s):  
Takumi Watanabe ◽  
Hikaru Abe ◽  
Isao Momose ◽  
Yoshikazu Takahashi ◽  
Daishiro Ikeda ◽  
...  
Keyword(s):  
Boronic Acid ◽  
Proteasome Inhibitors ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Boronic Acid Derivatives ◽  
Relationship Of ◽  
Derivatives Of

Tiliroside: Biosynthesis, Bioactivity and Structure activity relationship (SAR)- A review

2017 ◽  
Vol 6 (6) ◽  
pp. 343-348
Author(s):  
Lokadi Pierre Luhata ◽  
◽  
Wembi Gaston Luhata ◽  
◽  
Keyword(s):  
Acute Inflammation ◽  
Shikimate Pathway ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Coumaric Acid ◽  
Acid Moiety ◽  
Structure Activity ◽  
Starter Unit ◽  
Anti Inflammatory ◽  
Relationship Of

Tilirosides (TLD) are glycosidic flavonoids (GFD) from originating in plants that exhibit a range of bioactivities of great interest for healthcare: antioxidant, anti-microbial, antifungal, anti-diabetic and antihyperlipedemic, antiviral and cytotoxic, anti–inflammatory, anti-rheumatism, inhibition of neuroinflammation and acute inflammation and hepatoprotective activities. TLD are biosynthesized in plants in three main steps. First, the synthesis of the aglycone (a flavonoid) occurs, which follows the shikimate pathway with cinnamoylCoA as a starter unit. Second, there is the glucosylation of the aglycone using Uridine diphosphosugar (UDPglucose) as the agent for glycosylation. Finally, the coumaroyl part is added. The Structure Activity Relationship of TLD reveals that the addition of the para coumaric acid moiety considerably modifies their bioactivity.

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