ChemInform Abstract: Bioactive Clusters Promoting cell Penetration and Nucleic Acid Complexation for Drug and Gene Delivery Applications: From Designed to Self-Assembled and Responsive Systems

Recent developments in the (self-)assembly of cationic clusters promoting nucleic acids complexation and cell penetration open the door to applications in drug and gene delivery.

Download Full-text

Cyclodextrin-based self-assembled supramolecular hydrogels and cationic polyrotaxanes for drug and gene delivery applications

Journal of Drug Delivery Science and Technology ◽

10.1016/s1773-2247(10)50071-6 ◽

2010 ◽

Vol 20 (6) ◽

pp. 399-405 ◽

Cited By ~ 12

Author(s):

J. Li

Keyword(s):

Gene Delivery ◽

Self Assembled ◽

Drug And Gene Delivery

Download Full-text

Self-assembled biodegradable amphiphilic PEG–PCL–lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery

Biomaterials ◽

10.1016/j.biomaterials.2011.06.064 ◽

2011 ◽

Vol 32 (30) ◽

pp. 7721-7731 ◽

Cited By ~ 124

Author(s):

Thomas K. Endres ◽

Moritz Beck-Broichsitter ◽

Olga Samsonova ◽

Thomas Renette ◽

Thomas H. Kissel

Keyword(s):

Gene Delivery ◽

Triblock Copolymers ◽

Self Assembled ◽

Drug And Gene Delivery

Download Full-text

Graphene and Graphene-Based Materials in Biomedical Applications

Current Medicinal Chemistry ◽

10.2174/0929867326666190705155854 ◽

2019 ◽

Vol 26 (38) ◽

pp. 6834-6850 ◽

Cited By ~ 5

Author(s):

Mohammad Omaish Ansari ◽

Kalamegam Gauthaman ◽

Abdurahman Essa ◽

Sidi A. Bencherif ◽

Adnan Memic

Keyword(s):

Tissue Engineering ◽

Thermal Properties ◽

Gene Delivery ◽

Regenerative Medicine ◽

Biomedical Research ◽

Biomedical Applications ◽

Biomedical Application ◽

Two Dimensional ◽

Drug And Gene Delivery ◽

Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

Download Full-text

Redox-Sensitive Smart Nanosystems for Drug and Gene Delivery

Current Organic Chemistry ◽

10.2174/1385272820666160510154557 ◽

2016 ◽

Vol 20 (28) ◽

pp. 2949-2959 ◽

Cited By ~ 8

Author(s):

Mahdi Karimi ◽

Seyed Basri ◽

Manouchehr Vossoughi ◽

Parvin Pakchin ◽

Hamed Mirshekari ◽

...

Keyword(s):

Gene Delivery ◽

Drug And Gene Delivery

Download Full-text

Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment

Pharmaceutics ◽

10.3390/pharmaceutics13070940 ◽

2021 ◽

Vol 13 (7) ◽

pp. 940

Author(s):

Chaojie Zhu ◽

Zhiheng Ji ◽

Junkai Ma ◽

Zhijie Ding ◽

Jie Shen ◽

...

Keyword(s):

Gene Delivery ◽

Cancer Treatment ◽

Delivery Systems ◽

Cancer Targeting ◽

Cancer Treatments ◽

Recent Advances ◽

Therapeutic Mechanisms ◽

Bacterial Therapy ◽

Targeting Ability ◽

Drug And Gene Delivery

Cancer is one of the most devastating and ubiquitous human diseases. Conventional therapies like chemotherapy and radiotherapy are the most widely used cancer treatments. Despite the notable therapeutic improvements that these measures achieve, disappointing therapeutic outcome and cancer reoccurrence commonly following these therapies demonstrate the need for better alternatives. Among them, bacterial therapy has proven to be effective in its intrinsic cancer targeting ability and various therapeutic mechanisms that can be further bolstered by nanotechnology. In this review, we will discuss recent advances of nanotechnology-facilitated bacteria-based drug and gene delivery systems in cancer treatment. Therapeutic mechanisms of these hybrid nanoformulations are highlighted to provide an up-to-date understanding of this emerging field.

Download Full-text