scholarly journals N‐terminal pro‐brain natriuretic peptide and short‐term mortality in acute aortic dissection: A meta‐analysis

2020 ◽  
Vol 43 (11) ◽  
pp. 1255-1259
Author(s):  
Mislav Vrsalovic ◽  
Ana Vrsalovic Presecki ◽  
Victor Aboyans
Keyword(s):  
Aortic Dissection ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Acute Aortic Dissection ◽  
Meta Analysis ◽  
Short Term ◽  
Short Term Mortality

scholarly journals Prognostic Value of Brain Natriuretic Peptide in Noncardiac Surgery

2009 ◽  
Vol 111 (2) ◽  
pp. 311-319 ◽  
Author(s):  
Alisdair D. S. Ryding ◽  
Saurabh Kumar ◽  
Angela M. Worthington ◽  
David Burgess
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cardiac Death ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Noncardiac Surgery ◽  
Cardiac Mortality ◽  
Short Term ◽  
Increased Risk ◽  
All Cause Mortality

Background The prognostic role of brain natriuretic peptide (BNP) measurement before noncardiac surgery is unclear. The authors therefore performed a meta-analysis of studies in patients undergoing noncardiac surgery to assess the prognostic value of elevated BNP or N-terminal pro-BNP (NT-proBNP) levels in predicting mortality and major adverse cardiovascular events (MACE) (cardiac death or nonfatal myocardial infarction). Methods Unrestricted searches of MEDLINE and EMBASE bibliographic databases were performed using the terms "brain natriuretic peptide," "b-type natriuretic peptide," "BNP," "NT-proBNP," and "surgery." In addition, review articles, bibliographies, and abstracts of scientific meetings were manually searched. The meta-analysis included prospective studies that reported on the association of BNP or NT-proBNP and postoperative major adverse cardiovascular event (MACE) or mortality. The study endpoints were MACE, all-cause mortality, and cardiac mortality at short-term (less than 43 days after surgery) and longer-term (more than 6 months) follow-up. A random-effects model was used to pool study results; funnel-plot inspection was done to evaluate publication bias; Cochrane chi-square test and I testing was used to test for heterogeneity. Results Data from 15 publications (4,856 patients) were included in the analysis. Preoperative BNP elevation was associated with an increased risk of short-term MACE (OR 19.77; 95% confidence interval [CI] 13.18-29.65; P < 0.0001), all-cause mortality (OR 9.28; 95% CI 3.51-24.56; P < 0.0001), and cardiac death (OR 23.88; 95% CI 9.43-60.43; P < 0.00001). Results were consistent for both BNP and NT-proBNP. Preoperative BNP elevation was also associated with an increased risk of long-term MACE (OR 17.70; 95% CI 3.11-100.80; P < 0.0001) and all-cause mortality (OR 4.77; 95% CI 2.99-7.46; P < 0.00001). Conclusions Elevated BNP and NT-proBNP levels identify patients undergoing major noncardiac surgery at high risk of cardiac mortality, all-cause mortality, and MACE.

scholarly journals N-Terminal Pro-Brain Natriuretic Peptide and Short-Term Mortality After Ischemic Stroke

2013 ◽  
Vol 44 (3) ◽  
pp. 248-253
Author(s):  
Mojdeh Ghabaee ◽  
Maryam Pourashraf ◽  
Reza Shahsiah ◽  
Majid Ghaffarpour ◽  
Sara Parviz ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Short Term ◽  
Short Term Mortality

Brain Natriuretic Peptide upon Admission as a Biological Marker of Short-Term Mortality after Intracerebral Hemorrhage

2014 ◽  
Vol 71 (3-4) ◽  
pp. 203-207 ◽  
Author(s):  
Yoshino Goya ◽  
Kensaku Shibazaki ◽  
Kenichiro Sakai ◽  
Junya Aoki ◽  
Jyunichi Uemura ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Biological Marker ◽  
Short Term ◽  
Short Term Mortality

Outcome of surgical repair of Stanford type A aortic dissection in elderly patients: a contemporary systematic review and meta-analysis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hani Abd El-Maabood Metwlly El-Galb ◽  
Ayman Mahmoud Amin Amar ◽  
Mohamed Nabil Mohamed Abd El-Gawad ◽  
Mohamed Ibrahim Reiad El-Kholey
Keyword(s):  
Aortic Dissection ◽  
Observational Studies ◽  
Meta Analysis ◽  
Kidney Injury ◽  
The Elderly ◽  
Short Term ◽  
Type A Aortic Dissection ◽  
Operative Outcomes ◽  
Increased Risk ◽  
Short Term Mortality

Abstract Background The results of surgical treatment of type A aortic dissection (AAD) in the elderly are controversial and aggravated by a higher operative mortality rate. The studies published in this subset of patients are mainly retrospective analyses or small samples from international registries. We sought to investigate this topic by conducting a contemporary meta-analysis of the most recent observational studies. Methods A systematic literature search was conducted for any study published from the inception till August 2019 on aortic dissection treated surgically in patients 70 years and older. A pooled risk-ratio meta-analysis has been conducted three main post-operative outcomes: short-term mortality, stroke and acute kidney injury. Results A total of 23 retrospective observational studies have been included in the metaanalysis. Pooled meta-analysis showed an increased risk of short-term mortality for the elderly population [relative risk (RR) =1.39; 95% CI, 0.64–3.5; I2=92%; P < 0.001], and this has been confirmed in a sub-analysis of patients 80 years and older. The risk of having stroke (RR = 1.47; 95% CI, 0.66–3.29; I2=91%; P = 0.35) and acute kidney injury (RR = 1.12; 95% CI, 0.32–3.9, I2=90%, P = 0.85) after surgery were comparable to the conservative treatment of patients. Conclusion Although affected by an increased risk of short-term mortality in the elderly, surgical repair remains the treatment of choice for AAD. The main post-operative outcomes are comparable to younger patients and the mid-term survival rates are acceptable.

The short-term prognostic value of serum platelet to hemoglobin in patients with type A acute aortic dissection

Perfusion ◽  
2020 ◽  
pp. 026765912098222
Author(s):  
Yu Wang ◽  
Tengfei Qiao ◽  
Jun Zhou
Keyword(s):  
Aortic Dissection ◽  
Hospital Mortality ◽  
Acute Aortic Dissection ◽  
Independent Predictor ◽  
Type A ◽  
Short Term ◽  
Survivor Group ◽  
Mortality Hazard ◽  
Mortality Hazard Ratio ◽  
The Ideal

Purpose: Type A acute aortic dissection (AAD) is an uncommon catastrophic cardiovascular disease with high pre-hospital mortality rate without timely and effectively treated. The aim of this study was to assess the value of serum platelet to hemoglobin (PHR) in predicting in-hospital mortality in type A AAD patients. Methods: A total of 183 type A AAD patients were included in this retrospective investigation from January 2017 to December 2019. Admission blood routine parameters were gathered and PHR was computed. The outcome was all-cause in-hospital mortality within 30 days. Results The average levels of serum PHR were significant higher in survivor group than those in non-survivor group (1.14 ± 0.57 vs 0.87 ± 0.47, p = 0.006) and serum PHR was an independent factor associated with in-hospital mortality (hazard ratio (HR): 2.831; 95% confidence interval (CI): 1.108–7.231; p = 0.030). ROC noted that 0.8723 was chosen as the ideal cutoff value with a sensitivity of 64.3% and specificity of 72.5%. In addition, the area under the ROC curve (AUC) was 0.693 (95% CI 0.599–0.787, p < 0.001). Conclusion: Admission serum PHR can be used as an independent predictor of in-hospital mortality in patients with type A AAD.

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