scholarly journals Inside Cover: Rational Design of Ruthenium Complexes Containing 2,6-Bis(benzimidazolyl)pyridine Derivatives with Radiosensitization Activity by Enhancing p53 Activation (ChemMedChem 6/2015)

ChemMedChem ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. 934-934
Author(s):  
Zhiqin Deng ◽  
Lianling Yu ◽  
Wenqiang Cao ◽  
Wenjie Zheng ◽  
Tianfeng Chen
Keyword(s):  
Rational Design ◽  
Ruthenium Complexes ◽  
Pyridine Derivatives ◽  
P53 Activation

Rational Design of Ruthenium Complexes Containing 2,6-Bis(benzimidazolyl)pyridine Derivatives with Radiosensitization Activity by Enhancing p53 Activation

ChemMedChem ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. 991-998 ◽  
Author(s):  
Zhiqin Deng ◽  
Lianling Yu ◽  
Wenqiang Cao ◽  
Wenjie Zheng ◽  
Tianfeng Chen
Keyword(s):  
Rational Design ◽  
Ruthenium Complexes ◽  
Pyridine Derivatives ◽  
P53 Activation

A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling

2015 ◽  
Vol 51 (13) ◽  
pp. 2637-2640 ◽  
Author(s):  
Zhiqin Deng ◽  
Lianling Yu ◽  
Wenqiang Cao ◽  
Wenjie Zheng ◽  
Tianfeng Chen
Keyword(s):  
Rational Design ◽  
Ruthenium Complex ◽  
Ruthenium Complexes

We have described the rational design of selenium-containing ruthenium complexes and their use as cancer radiosensitizers through regulating ROS-mediated pathways.

Linear Neutral Receptors for Anions: Synthesis, Structure and Applications

Synthesis ◽  
2018 ◽  
Vol 50 (23) ◽  
pp. 4555-4568 ◽  
Author(s):  
Janusz Jurczak ◽  
Agnieszka Cholewiak ◽  
Pawel Stepniak
Keyword(s):  
Hydrogen Bond ◽  
Steric Hindrance ◽  
Rational Design ◽  
Anion Receptors ◽  
Benzene Derivatives ◽  
Pyridine Derivatives ◽  
Naphthalene Derivatives ◽  
Pyrrole Derivatives ◽  
Anthracene Derivatives ◽  
Shed Light

A selective digest of linear anion receptors based on different aromatic skeletons is presented. Since the structures of anions vary from one to another, different strategies have been developed over recent years in order to bind anions efficiently and selectively. Rigidity, number of hydrogen bond donors, steric hindrance, and special preorganization of linear receptors are analyzed to shed light on the rational design of anion receptors.1 Introduction2 1,3- and 1,2-Benzene Derivatives3 1,3- and 5,7-Azulene Derivatives4 1,8-Naphthalene Derivatives5 1,8-Anthracene Derivatives6 2,6-Pyridine Derivatives7 2,5-Pyrrole Derivatives8 Diamidoarenodipyrrole Derivatives9 Carbazole Derivatives10 DITIPIRAM Derivatives11 Conclusion

Near-IR dye-sensitized solar cells using a new type of ruthenium complexes having 2,6-bis(quinolin-2-yl)pyridine derivatives

2011 ◽  
Vol 95 (1) ◽  
pp. 310-314 ◽  
Author(s):  
Nobuko Onozawa-Komatsuzaki ◽  
Masatoshi Yanagida ◽  
Takashi Funaki ◽  
Kazuyuki Kasuga ◽  
Kazuhiro Sayama ◽  
...  
Keyword(s):  
Solar Cells ◽  
Dye Sensitized Solar Cells ◽  
Ruthenium Complexes ◽  
Pyridine Derivatives ◽  
Dye Sensitized ◽  
Near Ir ◽  
New Type ◽  
Sensitized Solar Cells

scholarly journals Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide

2019 ◽  
Author(s):  
BL Allen ◽  
K Quach ◽  
CB Levandowski ◽  
JD Rubin ◽  
T Read ◽  
...  
Keyword(s):  
Rational Design ◽  
Human Cancer ◽  
Transcriptional Response ◽  
Molecular Probes ◽  
Activation Domains ◽  
Stapled Peptide ◽  
Human Cancer Cells ◽  
P53 Response ◽  
P53 Activation

AbstractDNA-binding transcription factors (TFs) remain challenging to target with molecular probes. Many TFs function in part through interaction with Mediator; we sought to block p53 function by disrupting the p53-Mediator interaction. Through rational design and activity-based screening, we characterized a stapled peptide, with functional mimics of both p53 activation domains, that selectively inhibited p53- and Mediator-dependent transcription in vitro. This “bivalent peptide” also suppressed p53 transcriptional response in human cancer cells. Our strategy circumvents the TF and instead targets the TF-Mediator interface, with desired transcriptional outcomes. Different TFs target Mediator through different subunits, suggesting this strategy could be broadly applied.

Rational Design of Phenyl Thiophene (Pyridine) Derivatives that Overcome P-Glycoprotein Mediated MDR in MCF-7/ADR cell

2021 ◽  
pp. 105075
Author(s):  
Ya-Sheng Li ◽  
Shen Mao ◽  
Dong-Sheng Zhao ◽  
Can-Can Wang ◽  
Dan Zu ◽  
...  
Keyword(s):  
Rational Design ◽  
Pyridine Derivatives ◽  
P Glycoprotein ◽  
Mcf 7

Ruthenium complexes containing 2,6-bis(benzimidazolyl)pyridine derivatives induce cancer cell apoptosis by triggering DNA damage-mediated p53 phosphorylation

2012 ◽  
Vol 41 (41) ◽  
pp. 12766 ◽  
Author(s):  
Linlin Li ◽  
Wenqiang Cao ◽  
Wenjie Zheng ◽  
Cundong Fan ◽  
Tianfeng Chen
Keyword(s):  
Dna Damage ◽  
Cancer Cell ◽  
Cell Apoptosis ◽  
Ruthenium Complexes ◽  
Pyridine Derivatives ◽  
Cancer Cell Apoptosis ◽  
Induce Cancer Cell Apoptosis

Rational Design and Convenient Synthesis of a Novel Family of Ruthenium Complexes with O,N-Bidentate Ligands

ChemInform ◽  
2006 ◽  
Vol 37 (39) ◽  
Author(s):  
Renate Drozdzak ◽  
Nele Ledoux ◽  
Bart Allaert ◽  
Ileana Dragutan ◽  
Valerian Dragutan ◽  
...  
Keyword(s):  
Rational Design ◽  
Ruthenium Complexes ◽  
Bidentate Ligands ◽  
Convenient Synthesis

Rational Design of Highly Cytotoxic η6-Arene β-Diketiminato−Ruthenium Complexes

2010 ◽  
Vol 29 (2) ◽  
pp. 417-427 ◽  
Author(s):  
Andrew D. Phillips ◽  
Olivier Zava ◽  
Rosario Scopelitti ◽  
Alexey A. Nazarov ◽  
Paul J. Dyson
Keyword(s):  
Rational Design ◽  
Ruthenium Complexes

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

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