Treatment-induced hearing loss and adult social outcomes in survivors of childhood CNS and non-CNS solid tumors: Results from the St. Jude Lifetime Cohort Study

Abstract Purpose To describe medium-term physical and mental health and social outcomes following adolescent sexual assault, and examine users’ perceived needs and experiences. Method Longitudinal, mixed methods cohort study of adolescents aged 13–17 years recruited within 6 weeks of sexual assault (study entry) and followed to study end, 13–15 months post-assault. Results 75/141 participants were followed to study end (53% retention; 71 females) and 19 completed an in-depth qualitative interview. Despite many participants accessing support services, 54%, 59% and 72% remained at risk for depressive, anxiety and post-traumatic stress disorders 13–15 months post-assault. Physical symptoms were reported more frequently. Persistent (> 30 days) absence from school doubled between study entry and end, from 22 to 47%. Enduring mental ill-health and disengagement from education/employment were associated with psychosocial risk factors rather than assault characteristics. Qualitative data suggested inter-relationships between mental ill-health, physical health problems and disengagement from school, and poor understanding from schools regarding how to support young people post-assault. Baseline levels of smoking, alcohol and ever drug use were high and increased during the study period (only significantly for alcohol use). Conclusion Adolescents presenting after sexual assault have high levels of vulnerability over a year post-assault. Many remain at risk for mental health disorders, highlighting the need for specialist intervention and ongoing support. A key concern for young people is disruption to their education. Multi-faceted support is needed to prevent social exclusion and further widening of health inequalities in this population, and to support young people in their immediate and long-term recovery.

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Failure of Noninvasive Ventilation in Acute Respiratory Failure is Associated with Higher Mortality in Patients with Solid Tumors: A Retrospective Cohort Study

Supportive Care in Cancer ◽

10.1007/s00520-021-06078-z ◽

2021 ◽

Author(s):

Francisco Valdez Lima ◽

Ludhmila Abrahão Hajjar ◽

Juliano Pinheiro Almeida ◽

Sergio Ramalho ◽

Gaspar Rogerio Chiappa ◽

...

Keyword(s):

Cohort Study ◽

Respiratory Failure ◽

Acute Respiratory Failure ◽

Solid Tumors ◽

Noninvasive Ventilation ◽

Retrospective Cohort Study ◽

Retrospective Cohort

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Comparisons of hearing threshold changes in male workers with unilateral conductive hearing loss exposed to workplace noise: a retrospective cohort study for 8 years

Annals of Occupational and Environmental Medicine ◽

10.1186/s40557-016-0132-1 ◽

2016 ◽

Vol 28 (1) ◽

Cited By ~ 1

Author(s):

Sang Jin Park ◽

Joo Hyun Sung ◽

Chang Sun Sim ◽

Seok Hyeon Yun ◽

Jeong Han Yeom ◽

...

Keyword(s):

Hearing Loss ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Conductive Hearing Loss ◽

Hearing Threshold ◽

Conductive Hearing ◽

Workplace Noise ◽

Male Workers

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SAT0114 Trends in the incidence of solid tumors in patients with rheumatoid arthritis in spain. a national observational cohort study.

10.1136/annrheumdis-2018-eular.3346 ◽

2018 ◽

Author(s):

V. Villaverde ◽

M. Fernandez-Prada ◽

R. Mazzucchelli ◽

E. Perez-Fernandez ◽

C. Macía-Villa ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Cohort Study ◽

Solid Tumors ◽

Observational Cohort Study ◽

Observational Cohort

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Association of sudden sensorineural hearing loss with increased risk of insomnia: a nationwide population-based cohort study

Journal of Clinical Sleep Medicine ◽

10.5664/jcsm.9864 ◽

2022 ◽

Author(s):

Cha Dong Yeo ◽

Sang Woo Yeom ◽

Yeon Seok You ◽

Jong Seung Kim ◽

Eun Jung Lee

Keyword(s):

Hearing Loss ◽

Cohort Study ◽

Sensorineural Hearing Loss ◽

Population Based ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Increased Risk

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Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study

BMJ Open ◽

10.1136/bmjopen-2020-038552 ◽

2020 ◽

Vol 10 (9) ◽

pp. e038552

Author(s):

Rishi Mandavia ◽

Gerjon Hannink ◽

Muhammad Nayeem Ahmed ◽

Yaami Premakumar ◽

Timothy Shun Man Chu ◽

...

Keyword(s):

Hearing Loss ◽

Cohort Study ◽

Sensorineural Hearing Loss ◽

Prospective Cohort Study ◽

Health Research ◽

Prospective Cohort ◽

Prognostic Model ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Adult Patients

IntroductionThe mainstay of treatment for idiopathic sudden sensorineural hearing loss (SSNHL) includes oral steroids, intratympanic steroid injections or a combination of both. The National Institute for Health and Care Excellence, in their recent hearing loss guidelines, highlighted the paucity of evidence assessing the comparative effectiveness of these treatments; and the National Institute for Health Research (NIHR) Health Technology Assessment Programme has since released a commissioned call for a trial to identify the most effective route of administration of steroids as a first-line treatment for idiopathic SSNHL. For such trials to be run effectively, reliable information is needed on patients with SSNHL: where they present, numbers, demographics, treatment pathways, as well as outcomes. This study will collect these data in a nationwide cohort study of patients presenting with SSNHL across 97 National Health Service (NHS) trusts. The study will be delivered through ear, nose and throat (ENT) trainee networks, the NIHR Clinical Research Network (CRN) Audiology Champions and the NIHR CRN. Importantly, this study will also provide a dataset to develop a prognostic model to predict recovery for patients with idiopathic SSNHL. The study objectives are to: (1) map the patient pathway and identify the characteristics of adult patients presenting to NHS ENT and hearing services with SSNHL, (2) develop a prognostic model to predict recovery for patients with idiopathic SSNHL and (3) establish the impact of idiopathic SSNHL on patients’ quality of life (QoL).Methods and analysisStudy design: national multicentre prospective cohort study across 97 NHS trusts.Inclusion criteria: adult patients presenting to NHS ENT and hearing services with SSNHL.Outcomes: change in auditory function; change in QoL score.Analysis: multivariable prognostic model, using prespecified candidate predictors. Mean change in QoL scores will be calculated from initial presentation to follow-up.Ethics and disseminationHealth Research Authority and NHS Research Ethics Committee approved the study. Publication will be on behalf of study sites and collaborators.Trial registration numberClinicalTrials.gov Registry (NCT04108598).

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