Bovine leukemia virus linked to breast cancer but not coinfection with human papillomavirus: Case-control study of women in Texas

Viruses have been implicated in cancer development in both humans and animals. The role of viruses in cancer is typically to initiate cellular transformation through cellular DNA damage, although specific mechanisms remain unknown. Silent and long-term viral infections need to be present, in order to initiate cancer disease. In efforts to establish a causative role of viruses, first is needed to demonstrate the strength and consistency of associations in different populations. The aim of this study was to determine the association of bovine leukemia virus (BLV), a causative agent of leukemia in cattle, with breast cancer and its biomarkers used as prognosis of the severity of the disease (Ki67, HER2, hormonal receptors) in Colombian women. An unmatched, observational case–control study was conducted among women undergoing breast surgery between 2016–2018. Malignant samples (n = 75) were considered as cases and benign samples (n = 83) as controls. Nested-liquid PCR, in-situ PCR and immunohistochemistry were used for viral detection in blood and breast tissues. For the risk assessment, only BLV positive samples from breast tissues were included in the analysis. BLV was higher in cases group (61.3%) compared with controls (48.2%), with a statistically significant association between the virus and breast cancer in the unconditional logistic regression (adjusted-OR = 2.450,95%CI:1.088–5.517, p = 0.031). In this study, BLV was found in both blood and breast tissues of participants and an association between breast cancer and the virus was confirmed in Colombia, as an intermediate risk factor.

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Presence of human papillomavirus DNA in breast cancer: a Spanish case-control study

BMC Cancer ◽

10.1186/s12885-017-3308-3 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 14

Author(s):

Silvia Delgado-García ◽

Juan-Carlos Martínez-Escoriza ◽

Alfonso Alba ◽

Tina-Aurora Martín-Bayón ◽

Hortensia Ballester-Galiana ◽

...

Keyword(s):

Breast Cancer ◽

Human Papillomavirus ◽

Case Control Study ◽

Case Control ◽

Papillomavirus Dna ◽

Control Study

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The influence of polymorphisms in genes related to oxidative stress on breast cancer survival in a German case-control study

Das Gesundheitswesen ◽

10.1055/s-0030-1266733 ◽

2010 ◽

Vol 72 (08/09) ◽

Author(s):

P Seibold ◽

R Hein ◽

O Popanda ◽

D Flesch-Janys ◽

P Schmezer ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Survival ◽

Case Control Study ◽

Case Control ◽

Breast Cancer Survival ◽

Control Study

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Influence of body mass index on breast cancer risk related dietary patterns among women in Northern Tanzania: a case-control study

Das Gesundheitswesen ◽

10.1055/s-0031-1283501 ◽

2011 ◽

Vol 73 (08/09) ◽

Author(s):

I Jordan ◽

A Hebestreit ◽

B Swai ◽

M Krawinkel

Keyword(s):

Breast Cancer ◽

Body Mass Index ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Body Mass ◽

Dietary Patterns ◽

Case Control Study ◽

Case Control ◽

Northern Tanzania ◽

Control Study

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Reproductive Factors and Risk of Breast Cancer by Tumour Subtypes Among Ghanaian Women: A Population-Based Case-Control Study

SSRN Electronic Journal ◽

10.2139/ssrn.3426075 ◽

2019 ◽

Author(s):

Jonine Figueroa ◽

Brittny C. Davis Lynn ◽

Lawrence Edusei ◽

Nicholas Titiloye ◽

Ernest Adjei ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Reproductive Factors ◽

Population Based ◽

Case Control ◽

Ghanaian Women ◽

Control Study

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The J-shaped Association Between Alcohol Consumption and Breast Cancer: A Case-Control Study

Current Nutrition & Food Science ◽

10.2174/1573401310666140306005334 ◽

2014 ◽

Vol 10 (2) ◽

pp. 120-127

Author(s):

Niki Mourouti ◽

Meropi Kontogianni ◽

Christos Papavagelis ◽

Theodora Psaltopoulou ◽

Petrini Plytzanopoulou ◽

...

Keyword(s):

Breast Cancer ◽

Alcohol Consumption ◽

Case Control Study ◽

Case Control ◽

Control Study

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A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer

Scientific Reports ◽

10.1038/s41598-021-95955-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mariem Hajji-Louati ◽

Emilie Cordina-Duverger ◽

Nasser Laouali ◽

Francesca-Romana Mancini ◽

Pascal Guénel

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Odds Ratio ◽

Hormone Receptors ◽

Case Control Study ◽

Breast Cancer Subtype ◽

Case Control ◽

Tumor Subtype ◽

Control Study

AbstractDietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of diet and breast cancer risk in a case–control study in France including 872 breast cancer cases and 966 population controls. All women completed a food frequency questionnaire that was used to compute a Dietary Inflammatory Index (DII) based on the inflammatory weight of 33 dietary components. The DII ranged from a median of − 3.22 in the lowest quartile (anti-inflammatory) to + 2.96 in the highest quartile (pro-inflammatory). The odds ratio contrasting quartile 4 to quartile 1 was 1.31 (95% CI 1.00, 1.73; p-trend = 0.02). Slightly higher odds ratios were observed in post-menopausal women, particularly those with body mass index > 25 kg/m2 (odds ratio 1.62; 95% CI 0.92, 2.83; p-trend = 0.02), and among ever smokers (odds ratio 1.71; 95% CI 1.11, 2.65; p-trend 0.01). The analyses by breast cancer subtype showed that the DII was associated with breast tumors that expressed either the estrogen (ER) or progesterone (PR) hormone receptors or the Human Epidermal Growth Factor Receptor-2 (HER2), but no association was seen for the triple negative breast tumor subtype. Our results add further evidence that a pro-inflammatory diet is associated with breast cancer risk with possible effect variation according to tumor subtype.

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