scholarly journals Long noncoding RNA IL6‐AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR‐149‐5p and early B‐cell factor 1

2021 ◽  
Vol 11 (7) ◽  
Author(s):  
Erkang Yi ◽  
Jiahuan Zhang ◽  
Mengning Zheng ◽  
Yi Zhang ◽  
Chunxiao Liang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
B Cell ◽  
Pulmonary Disease ◽  
Interleukin 6 ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Early B Cell Factor

scholarly journals B Cell–Adaptive Immune Profile in Emphysema-Predominant Chronic Obstructive Pulmonary Disease

2019 ◽  
Vol 200 (11) ◽  
pp. 1434-1439 ◽  
Author(s):  
John-Lawrence Sullivan ◽  
Bhavani Bagevalu ◽  
Carolyn Glass ◽  
Lynette Sholl ◽  
Monica Kraft ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
B Cell ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Immune Profile ◽  
Adaptive Immune

scholarly journals Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease

2013 ◽  
Vol 14 (1) ◽  
pp. 24 ◽  
Author(s):  
Renata Ferrari ◽  
Suzana E Tanni ◽  
Laura MO Caram ◽  
Corina Corrêa ◽  
Camila R Corrêa ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Interleukin 6 ◽  
Chronic Obstructive ◽  
C Reactive Protein ◽  
Obstructive Pulmonary Disease ◽  
Reactive Protein

scholarly journals Mendelian Randomization Study of Interleukin-6 in Chronic Obstructive Pulmonary Disease

Respiration ◽  
2011 ◽  
Vol 82 (6) ◽  
pp. 530-538 ◽  
Author(s):  
Yannick M.T.A. van Durme ◽  
Lies Lahousse ◽  
Katia M.C. Verhamme ◽  
Lisette Stolk ◽  
Mark Eijgelsheim ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Interleukin 6 ◽  
Mendelian Randomization ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Role of B Cell–Activating Factor in Chronic Obstructive Pulmonary Disease

2015 ◽  
Vol 192 (6) ◽  
pp. 706-718 ◽  
Author(s):  
Leen J. M. Seys ◽  
Fien M. Verhamme ◽  
Anja Schinwald ◽  
Hamida Hammad ◽  
Danen Mootoosamy Cunoosamy ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
B Cell ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
B Cell Activating Factor

scholarly journals B Cell–Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease

2015 ◽  
Vol 192 (6) ◽  
pp. 695-705 ◽  
Author(s):  
Francesca Polverino ◽  
Borja G. Cosio ◽  
Jaime Pons ◽  
Maria Laucho-Contreras ◽  
Paula Tejera ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
B Cell ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lymphoid Follicles ◽  
B Cell Activating Factor

scholarly journals THE ROLE OF INTERLEUKIN-6 SIGNALING IN DEVELOPMENT OF SYSTEMIC INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2018 ◽  
Vol 1 (69) ◽  
pp. 97-106 ◽  
Author(s):  
Татьяна Виткина ◽  
Tatyana Vitkina ◽  
К Сидлецкая ◽  
K Sidleckaya
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Systemic Inflammation ◽  
Interleukin 6 ◽  
Inflammatory Process ◽  
Molecular Mechanisms ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Damage Initiation

The review focuses on the role of interleukin-6 (IL-6) signaling in the development of a systemic inflammatory process in chronic obstructive pulmonary disease (COPD). In most researches the attention is paid to local inflammation in COPD. However, it is known that the pathology is characterized by a systemic inflammatory process, which is manifested in the increased levels of proinflammatory mediators in blood flow, and the study of the molecular mechanisms of its development is very important for the therapy of the disease. One of the key mediators of systemic inflammation is cytokine IL-6 which has pro- and antiinflammatory properties. Its effect on the cells is determined by the type of signaling. Nowadays three types of IL-6 signaling are identified: transsignaling, classical and cluster signaling. The review presents the known pathophysiological mechanisms of the development of systemic inflammation in COPD involving IL-6. As a proinflammatory cytokine, IL-6 performs the following functions: transmission of a signal on lung tissue damage, initiation of leukocyte migration into the inflammation site, inhibition of T-cell apoptosis into the inflammation site, influence on T helper differentiation, participation in pathophysiological reactions of development of emphysema and fibrosis. The significance of IL-6 transsignaling for the development of inflammation in COPD has been confirmed by many studies, while there are practically no works devoted to the study of classical IL-6 signaling in COPD. The data presented in the review indicate the need for further study of the role of different types of IL-6 signaling, especially classical signaling, in the regulation of systemic inflammation in COPD.

Association Between Interleukin-6 Blood Level and Chronic Obstructive Pulmonary Disease Severity

2020 ◽  
Vol 17 (7) ◽  
pp. 3097-3103
Author(s):  
Theopilus Obed Lay ◽  
Muhammad Amin
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Proinflammatory Cytokines ◽  
Interleukin 6 ◽  
Chronic Obstructive ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Severity Level ◽  
Copd Patients ◽  
Significant Difference

Chronic obstructive pulmonary disease (COPD) is known as a chronic inflammatory disease that not only occurs in the lung, but also affects the systemic. A continuous chronic inflammation in COPD patients will have an increased proinflammatory cytokines, both in COPD patients’ respiratory tract and blood. Interleukin-6 (IL-6) is one of proinflammatory cytokines that increases with COPD progression. IL-6 level examination in COPD patient’s blood as a systemic inflammation indicator is convenient and quick. The research aimed to measure IL-6 level in COPD patient’s serum, to determine COPD severity level, and to analyze correlation between IL-6 and severity level. The research is an observational analytic study using cross sectional design. The samples were 38 non-exacerbated COPD outpatients who visited Lung Unit at Dr. Soetomo Teaching Hospital, Surabaya, Indonesia and met inclusion and exclusion criteria. The study found no significant correlation between IL-6, COPD severity level, COPD obstruction, first forced expiratory volume (FEV1), and FEV1/forced vital capacity (FVC), with p > 0.05. There was a significant correlation between IL-6 level, body mass index (BMI), and COPD assessment test (CAT) score, with p < 0.05, while there was no significant difference of IL-6 level between high-risk and low-risk patients, with p = 0.066 (p > 0.05). Moreover, there was a significant difference of IL-6 level between group A and D, with p = 0.040 (p < 0.05). There were no significant correlation and difference between COPD severities, COPD obstruction, FEV1, FVC, FEV1/FEC ratio, smoking duration with stable IL-6.

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